KEGG   PATHWAY: sce00010Help
Entry
sce00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Saccharomyces cerevisiae (budding yeast)
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Glycolysis / Gluconeogenesis
sce00010

All organismsOrtholog table
Module
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:sce00010]
Glycolysis, core module involving three-carbon compounds [PATH:sce00010]
Gluconeogenesis, oxaloacetate => fructose-6P [PATH:sce00010]
Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:sce00010]
Other DBs
BSID: 
GO: 
Organism
Saccharomyces cerevisiae (budding yeast) [GN:sce]
Gene
HXK2; hexokinase 2 [KO:K00844] [EC:2.7.1.1]
HXK1; hexokinase 1 [KO:K00844] [EC:2.7.1.1]
GLK1; glucokinase [KO:K00844] [EC:2.7.1.1]
EMI2; putative glucokinase [KO:K00844] [EC:2.7.1.1]
PGI1; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
PFK2; 6-phosphofructokinase subunit beta [KO:K00850] [EC:2.7.1.11]
PFK1; 6-phosphofructokinase subunit alpha [KO:K00850] [EC:2.7.1.11]
FBP1; fructose 1,6-bisphosphate 1-phosphatase [KO:K03841] [EC:3.1.3.11]
FBA1; fructose-bisphosphate aldolase FBA1 [KO:K01624] [EC:4.1.2.13]
TPI1; triose-phosphate isomerase TPI1 [KO:K01803] [EC:5.3.1.1]
TDH3; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 [KO:K00134] [EC:1.2.1.12]
TDH1; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1 [KO:K00134] [EC:1.2.1.12]
TDH2; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 [KO:K00134] [EC:1.2.1.12]
PGK1; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
GPM2; phosphoglycerate mutase family protein GPM2 [KO:K01834] [EC:5.4.2.11]
GPM1; phosphoglycerate mutase GPM1 [KO:K01834] [EC:5.4.2.11]
GPM3; phosphoglycerate mutase family protein GPM3 [KO:K01834] [EC:5.4.2.11]
phosphoglycerate mutase; K15634 probable phosphoglycerate mutase [EC:5.4.2.12] [KO:K15634] [EC:5.4.2.12]
SHB17; Shb17p [KO:K15634] [EC:5.4.2.12]
ERR3; phosphopyruvate hydratase ERR3 [KO:K01689] [EC:4.2.1.11]
ENO1; phosphopyruvate hydratase ENO1 [KO:K01689] [EC:4.2.1.11]
ENO2; phosphopyruvate hydratase ENO2 [KO:K01689] [EC:4.2.1.11]
ERR1; phosphopyruvate hydratase ERR1 [KO:K01689] [EC:4.2.1.11]
ERR2; phosphopyruvate hydratase ERR2 [KO:K01689] [EC:4.2.1.11]
CDC19; pyruvate kinase CDC19 [KO:K00873] [EC:2.7.1.40]
PYK2; pyruvate kinase PYK2 [KO:K00873] [EC:2.7.1.40]
PDA1; pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha [KO:K00161] [EC:1.2.4.1]
PDB1; pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta [KO:K00162] [EC:1.2.4.1]
LAT1; dihydrolipoyllysine-residue acetyltransferase [KO:K00627] [EC:2.3.1.12]
IRC15; Irc15p [KO:K00382] [EC:1.8.1.4]
LPD1; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
THI3; branched-chain-2-oxoacid decarboxylase THI3 [KO:K01568] [EC:4.1.1.1]
PDC6; indolepyruvate decarboxylase 6 [KO:K01568] [EC:4.1.1.1]
PDC1; indolepyruvate decarboxylase 1 [KO:K01568] [EC:4.1.1.1]
PDC5; indolepyruvate decarboxylase 5 [KO:K01568] [EC:4.1.1.1]
SFA1; bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase [KO:K00121] [EC:1.1.1.1 1.1.1.284]
ADH1; alcohol dehydrogenase ADH1 [KO:K13953] [EC:1.1.1.1]
ADH2; alcohol dehydrogenase ADH2 [KO:K13953] [EC:1.1.1.1]
ADH5; alcohol dehydrogenase ADH5 [KO:K13953] [EC:1.1.1.1]
ADH3; alcohol dehydrogenase ADH3 [KO:K13953] [EC:1.1.1.1]
ADH4; alcohol dehydrogenase ADH4 [KO:K13954] [EC:1.1.1.1]
ADH7; Adh7p [KO:K00002] [EC:1.1.1.2]
ADH6; Adh6p [KO:K00002] [EC:1.1.1.2]
ALD4; aldehyde dehydrogenase (NADP(+)) ALD4 [KO:K00128] [EC:1.2.1.3]
ALD6; aldehyde dehydrogenase (NADP(+)) ALD6 [KO:K00128] [EC:1.2.1.3]
ALD5; aldehyde dehydrogenase (NAD(P)(+)) ALD5 [KO:K00128] [EC:1.2.1.3]
ALD3; aldehyde dehydrogenase (NAD(+)) ALD3 [KO:K00129] [EC:1.2.1.5]
ALD2; aldehyde dehydrogenase (NAD(+)) ALD2 [KO:K00129] [EC:1.2.1.5]
ACS1; acetate--CoA ligase 1 [KO:K01895] [EC:6.2.1.1]
ACS2; acetate--CoA ligase ACS2 [KO:K01895] [EC:6.2.1.1]
GAL10; bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase [KO:K01784 K01785] [EC:5.1.3.2 5.1.3.3]
PGM2; phosphoglucomutase PGM2 [KO:K01835] [EC:5.4.2.2]
PGM1; phosphoglucomutase PGM1 [KO:K01835] [EC:5.4.2.2]
PGM3; phosphoglucomutase PGM3 [KO:K01835] [EC:5.4.2.2]
glucose-6-phosphate 1-epimerase; K01792 glucose-6-phosphate 1-epimerase [EC:5.1.3.15] [KO:K01792] [EC:5.1.3.15]
PCK1; phosphoenolpyruvate carboxykinase PCK1 [KO:K01610] [EC:4.1.1.49]
Compound
C00022  
Pyruvate
C00024  
Acetyl-CoA
C00031  
D-Glucose
C00033  
Acetate
C00036  
Oxaloacetate
C00068  
Thiamin diphosphate
C00074  
Phosphoenolpyruvate
C00084  
Acetaldehyde
C00103  
D-Glucose 1-phosphate
C00111  
Glycerone phosphate
C00118  
D-Glyceraldehyde 3-phosphate
C00186  
(S)-Lactate
C00197  
3-Phospho-D-glycerate
C00221  
beta-D-Glucose
C00236  
3-Phospho-D-glyceroyl phosphate
C00267  
alpha-D-Glucose
C00469  
Ethanol
C00631  
2-Phospho-D-glycerate
C00668  
alpha-D-Glucose 6-phosphate
C01159  
2,3-Bisphospho-D-glycerate
C01172  
beta-D-Glucose 6-phosphate
C01451  
Salicin
C05125  
2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  
beta-D-Fructose 6-phosphate
C05378  
beta-D-Fructose 1,6-bisphosphate
C06186  
Arbutin
C06187  
Arbutin 6-phosphate
C06188  
Salicin 6-phosphate
C15972  
Enzyme N6-(lipoyl)lysine
C15973  
Enzyme N6-(dihydrolipoyl)lysine
C16255  
[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
KO pathway
 

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