Valine, leucine and isoleucine degradation

Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:sen00280]

2-oxoisovalerate:ferredoxin oxidoreductase [PATH:sen00280]

branched-chain amino acid aminotransferase; K00826 branched-chain amino acid aminotransferase [EC:2.6.1.42] [KO:K00826] [EC:2.6.1.42]

branched-chain amino acid aminotransferase; K00826 branched-chain amino acid aminotransferase [EC:2.6.1.42] [KO:K00826] [EC:2.6.1.42]

pyruvate dehydrogenase (acetyl-transferring) beta subunit; K11381 2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4] [KO:K11381] [EC:1.2.4.4]

dldH2; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]

lpdA; flavoprotein disulfide reductase [KO:K00382] [EC:1.8.1.4]

pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]

fadE21; acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]

acyl-CoA dehydrogenase; K00249 acyl-CoA dehydrogenase [EC:1.3.8.7] [KO:K00249] [EC:1.3.8.7]

acyl-CoA dehydrogenase; K00249 acyl-CoA dehydrogenase [EC:1.3.8.7] [KO:K00249] [EC:1.3.8.7]

acdA; acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]

fadE22; acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]

fadE31; acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]

acyl-CoA dehydrogenase; K00249 acyl-CoA dehydrogenase [EC:1.3.8.7] [KO:K00249] [EC:1.3.8.7]

acyl-CoA dehydrogenase; K00249 acyl-CoA dehydrogenase [EC:1.3.8.7] [KO:K00249] [EC:1.3.8.7]

fadE1; acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]

fadE13; acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]

acyl-CoA dehydrogenase; K00249 acyl-CoA dehydrogenase [EC:1.3.8.7] [KO:K00249] [EC:1.3.8.7]

echA; enoyl-CoA hydratase-isomerase [KO:K01692] [EC:4.2.1.17]

enoyl-CoA hydratase/carnithine racemase; K01692 enoyl-CoA hydratase [EC:4.2.1.17] [KO:K01692] [EC:4.2.1.17]

echA5; enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]

echA9; enoyl-CoA hydratase/isomerase [KO:K01692] [EC:4.2.1.17]

fadB; 3-hydroxyacyl-CoA dehydrogenase [KO:K01782] [EC:5.1.2.3 4.2.1.17 1.1.1.35]

fadA; 3-ketoacyl-CoA thiolase [KO:K00632] [EC:2.3.1.16]

acetyl/propionyl-CoA carboxylase subunit alpha; K00632 acetyl-CoA acyltransferase [EC:2.3.1.16] [KO:K00632] [EC:2.3.1.16]

acetyl-CoA carboxylase subunit alpha; K01965 propionyl-CoA carboxylase alpha chain [EC:6.4.1.3] [KO:K01965] [EC:6.4.1.3]

pccB; propionyl-CoA carboxylase subunit beta [KO:K01966] [EC:6.4.1.3]

methylmalonyl-CoA epimerase; K05606 methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1] [KO:K05606] [EC:5.1.99.1]

mutB; methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]

mutA; methylmalonyl-CoA mutase subunit beta [KO:K01847] [EC:5.4.99.2]

6-phosphogluconate dehydrogenase; K00020 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31] [KO:K00020] [EC:1.1.1.31]

mmsB; 3-hydroxyisobutyrate dehydrogenase [KO:K00020] [EC:1.1.1.31]

6-phosphogluconate dehydrogenase; K00020 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31] [KO:K00020] [EC:1.1.1.31]

mmsA2; methylmalonate-semialdehyde dehydrogenase [KO:K00140] [EC:1.2.1.27 1.2.1.18]

mmsA3; methylmalonate-semialdehyde dehydrogenase [KO:K00140] [EC:1.2.1.27 1.2.1.18]

mmsA1; methylmalonate-semialdehyde dehydrogenase [KO:K00140] [EC:1.2.1.27 1.2.1.18]

aldA; aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]

thcA; aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]

thcA; aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]

aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]

betaine-aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]

aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]

aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [KO:K00128] [EC:1.2.1.3]

aldH; aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]

gabT; 4-aminobutyrate aminotransferase [KO:K07250] [EC:2.6.1.22 2.6.1.19]

accD1; propionyl-CoA carboxylase subunit beta [KO:K01969] [EC:6.4.1.4]

echA21; enoyl-CoA hydratase [KO:K13766] [EC:4.2.1.18]

hmgL; hydroxymethylglutaryl-CoA lyase [KO:K01640] [EC:4.1.3.4]

hydroxymethylglutaryl-CoA lyase; K01640 hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] [KO:K01640] [EC:4.1.3.4]

hydroxymethylglutaryl-CoA lyase; K01640 hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] [KO:K01640] [EC:4.1.3.4]

mmgA; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]

fadA6; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]

acetyl-CoA acetyltransferase; K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [KO:K00626] [EC:2.3.1.9]

fadA4; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]

fadA; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]

catF; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]

fadA3; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]

Acetyl-CoA

Thiamin diphosphate

Succinyl-CoA

Propanoyl-CoA

L-Leucine

3-Methyl-2-oxobutanoic acid

Acetoacetate

L-Valine

4-Methyl-2-oxopentanoate

Acetoacetyl-CoA

(S)-3-Hydroxy-3-methylglutaryl-CoA

L-Isoleucine

2-Methylpropanoyl-CoA

(S)-3-Methyl-2-oxopentanoic acid

(S)-Methylmalonyl-CoA

(R)-Methylmalonyl-CoA

Methylmalonate

(3R)-beta-Leucine

3-Methylbutanoyl-CoA

3-Methylcrotonyl-CoA

3-Methylglutaconyl-CoA

L-3-Amino-isobutanoate

2-Methylacetoacetyl-CoA

2-Methylbut-2-enoyl-CoA

2-Methylprop-2-enoyl-CoA

beta-Ketoisocaproate

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA

Branched chain fatty acid

3-Hydroxyisovaleryl-CoA

(S)-3-Hydroxyisobutyryl-CoA

(S)-3-Hydroxyisobutyrate

(S)-Methylmalonate semialdehyde

Enzyme N6-(lipoyl)lysine

Enzyme N6-(dihydrolipoyl)lysine

3-Methyl-1-hydroxybutyl-ThPP

[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine

2-Methyl-1-hydroxypropyl-ThPP

[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine

2-Methyl-1-hydroxybutyl-ThPP

[Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine

(S)-2-Methylbutanoyl-CoA