KEGG   Sarcophilus harrisii (Tasmanian devil): 100918116Help
Entry
100918116         CDS       T02286                                 

Gene name
IRS1
Definition
insulin receptor substrate 1
Orthology
K16172  
insulin receptor substrate 1
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
cGMP-PKG signaling pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:shr00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    100918116 (IRS1)
   04022 cGMP - PKG signaling pathway
    100918116 (IRS1)
   04151 PI3K-Akt signaling pathway
    100918116 (IRS1)
   04152 AMPK signaling pathway
    100918116 (IRS1)
   04150 mTOR signaling pathway
    100918116 (IRS1)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    100918116 (IRS1)
   04920 Adipocytokine signaling pathway
    100918116 (IRS1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100918116 (IRS1)
  Nervous system
   04722 Neurotrophin signaling pathway
    100918116 (IRS1)
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    100918116 (IRS1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100918116 (IRS1)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100918116 (IRS1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Position
3
AA seq 1234 aa AA seqDB search
MASPPEGDGCFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSGA
PKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSESEQESWYQALLQLHNRAKG
HHLHHSHHEAAAFGVGGGGGGGGSCSGSSGLGEAGEDSSYGEMAPGPAFKEVWQVILKPK
GLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVT
GPGEFWMQVDDSVVAQNMHETILEAMRAMSEEFRPRSKSQSSSNCSNPISVPLRRHHLNN
PPPSQVGLTRRSRTESVTATSPASVVGGKPCSFRVRASSDGEGTMSRPASVDGSPVSPST
NRTHSHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRR
SSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEDLSNYICMGGK
NPPNLTAPNGHYNLSRSGIVHRYTPGAGPSPATVGDEVATAAELEKSFRKRTHSAGTSPT
ISHQKTPSQSSVASIEEYTEMMPSYPPCSAAGSGNRGQAYRHSAFVPTHSYPEECLEIHP
LEDRGGHHHHRVDTPVLHTDDGYMPMSPGVAPVPSGRKSGGDYMPMSPKSVSAPQQIINP
SRRHSQRVDPNGYMMMSPSGSCSPDSAGGSGSSNTVTSGNSYGKLWTNGVGGHHHHHVHP
KFSVESSDGKLPCSSDYINMSPAGDSVTSSPSDGYYGPDDPQNKAIYSYYSLPRSFKHTQ
QQQQXEDGGRLPHLRLSVSSGRLLYATAAEDSSSSASSDSLGGGGGTQEGAHGHLHHQAL
PQHLPRKADMVAQTKNRLTRPTRLSLDGPKASTLPRAREQPQQPLLPPEPKSPGEYVNIE
FVGDQPGYSHGSAISLCSPTVRCPSQRQPAPREDEAGSEEYMNMDLRPPRRPVCQESFVA
KAGRACPLPTGAGGVCRPSRVVPNSQDYVTMQVGGPCPGCADASLSYVVMQASKASEEPS
VPAAAAPAPSLPFTAAPPSLPQHQGQAELASRPSLLGGPKGPGGISAFTRVNLSPSRNQS
AKVIRADPQGCRRRHSSETFSSTPSASRGSNVAVPFGAAAAGGSGATGSSEDVKRHSSAS
FENVWLKPGDVGGPPSRKETSQMSGAAAGLENGLNYIDLDLVKDFNHRPQECPPLLQPPH
QPCGSGGASGNGCSSEDLSAYASISFQKQPEDLP
NT seq 3705 nt NT seq  +upstreamnt  +downstreamnt
atggcgagcccaccggagggggacggctgcttctccgacgtgcggaaggtgggctacctc
cgcaaacccaagagcatgcacaaacgcttcttcgtcctgcgggcggccagtgaggccggg
gggccggcccgcctggagtactatgagaacgagaagaagtggaggcacaaatccggtgcc
cccaagcgctctatcccgctggagagctgtttcaacatcaacaagcgggctgactccaaa
aacaaacacctggtagccctctacacccgggacgagcatttcgccattgccgcggatagc
gagtcggagcaggagagctggtaccaggcgctcctgcagctccacaaccgggccaaggga
catcacttgcaccattcccaccacgaggctgcagcttttggagtgggagggggaggaggc
ggaggggggagctgcagcggcagctctggcctgggagaagccggggaggacagtagctat
ggggaaatggccccaggaccagcattcaaggaggtttggcaagtgatcctgaagcctaag
ggcttggggcagacaaagaacctgattggcatctaccggctctgcctgaccagtaagacc
atcagctttgtgaagctgaactcggaggctgccgcagtggtcctccaactgatgaacatt
cgcaggtgtggtcactccgaaaacttcttttttattgaggtggggcgctctgcggtgact
ggacctggggagttctggatgcaagtggatgattccgtggttgcccagaatatgcacgag
accatcctggaagctatgcgggccatgagtgaggaattccggcctcggagcaagagccag
tcgtcctccaactgctccaaccccatcagcgtacccttacgcaggcatcacctcaataat
ccaccccccagccaggtggggctcacccgcagatcccggactgagagcgtcaccgccaca
tcacccgctagtgtcgtgggtgggaagccctgctctttccgagtccgggcatccagtgat
ggagaaggcaccatgtcccgaccggcctcggtggatgggagtcccgtaagccccagtacc
aaccggactcattcacaccggcatcggggcagctcccgcttgcacccgcccctcaaccac
agccgctccatcccgatgccttcctcccgatgttccccttcggccacgagtccggtcagc
ttatcgtccagcagcaccagtggccacgggtcgacctctgactgtctcttcccaaggagg
tccagtgcttccgtgtccggctcacccagcgatgggggtttcatctcttccgatgaatac
ggctctagcccgtgtgacttccgaagttccttccgcagcgtcactccggattccctgggt
cacaccccaccggccaggggggaagaagatctgagcaactatatctgcatgggaggcaaa
aacccgcctaacttgactgcccccaatggccactataacctatccagaagtggcatcgtg
caccgctataccccgggagctggcccgagtcctgccactgtgggagatgaggtagccact
gctgcagagctggagaagagtttccgcaagagaacacactcagcaggtacttctcctact
atttcccaccagaagacaccttctcagtcctccgtagcatccattgaagagtacacagag
atgatgccttcctacccgccctgttcagcggctggcagtgggaaccggggccaagcctac
cgccactcagcctttgtgcccacccactcctatcctgaggagtgtctggagatccatccc
ttggaggatcggggaggccaccaccatcaccgggtggatactccggtgctacatacagac
gacggctacatgcccatgtctcctggggtggctccggtgcccagtggccgaaagagcggt
ggagattacatgcccatgagccccaagagcgtatctgctccccagcagatcattaacccc
agcaggcgccattcgcagagggtagaccccaatggctacatgatgatgtctcccagtggc
agctgttccccagacagtgcaggtggctctggcagcagcaacacggtcacttctgggaac
agttacggcaagttatggacaaacggggtgggtggccaccaccaccaccacgttcacccg
aagttctctgtggagagcagtgacggcaagctaccttgcagcagcgattacatcaacatg
tcccctgctggggactctgtgaccagcagcccctcagacggttactatggcccagatgat
ccacaaaacaaggccatctactcttactactcattgccaagatccttcaaacacactcag
cagcagcagcagnntgaagatggtggccggctccctcacctgcgcctctcggtcagctcc
ggtcgcctcctgtacgccactgcagccgaggactcttcctcttctgccagcagtgatagc
ctgggaggaggtggaggcacacaggagggggcccatggccatctccatcatcaggccctg
ccacagcacctgccccggaaagcagacatggttgcccagaccaagaatcgcctaacccgg
cccaccaggctgtctctggatggccccaaggccagcaccttgcctagggctagggagcag
ccacagcagcctcttctgcccccagagcccaagagccccggagaatatgtgaacattgag
tttgtaggggaccagccgggctactcccacggctcggccatctccctctgctcgcccaca
gtcaggtgcccatcccagcgacagccggcccccagagaagatgaggctggctcagaggaa
tacatgaacatggacttgaggcctcctcggaggcctgtctgtcaggaaagctttgtggca
aaggctggcagagcatgccccctgcccaccggggcgggtggggtgtgtaggcccagtcgc
gtggtgccaaacagccaggattacgtgaccatgcaggtgggtgggccctgtcctggctgt
gcagatgcctccctcagctatgtggtcatgcaggcaagcaaggcttcggaggagcccagt
gtcccagctgctgcggctcctgccccttcccttccttttaccgcagcgcccccctctctc
ccccagcaccaaggacaggcagagctggctagccgcccatccctgttaggaggtccgaag
ggacccggagggattagcgcctttaccagagtgaacctcagtcccagccgcaaccagagt
gccaaagtgatccgggctgacccccaagggtgccggaggcggcacagctcggagaccttt
tcctccacccctagtgcttctcgaggcagtaacgtcgcggtgccctttggggccgctgcc
gcaggtggctctggggccactggcagcagcgaagatgttaaacgccacagttctgcctcc
tttgaaaatgtctggctaaagcctggggatgtcgggggcccacccagcaggaaggagaca
tcccagatgagcggggctgcagcgggtttagaaaatggactcaactacattgacctggat
ttggtcaaggattttaatcaccggccccaggagtgtccccctctgctgcagcctcctcat
cagccctgtggcagcggcggagccagtgggaacggctgctccagtgaggatctaagcgcc
tatgcgagcattagctttcagaagcagcccgaggaccttccatag

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