| Entry |
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| Gene name |
DOT1L
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| Definition |
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
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| Orthology |
| histone-lysine N-methyltransferase, H3 lysine-79 specific [EC: 2.1.1.43] |
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| Organism |
shr Sarcophilus harrisii (Tasmanian devil)
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| Pathway |
| Lysine degradation | | Transcriptional misregulation in cancer |
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| Class |
Metabolism; Amino acid metabolism; Lysine degradation [PATH: shr00310]
Human Diseases; Cancers; Transcriptional misregulation in cancers [PATH: shr05202]
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| SSDB |
   |
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| Motif |
 |
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| Other DBs |
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| Position |
2
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| AA seq |
1734 aa  
MWLDMLKKNYFGSCRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQ
LWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQM
IDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMK
WYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIV
SSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFS
SLKNPKLREEQEAARRRQQRENKSNTTTPTKVQENKGAVALEPRVDSGAEEDKNGTTTLK
KPSPSKPRKKKLNKKGRKMAGRKRGRPKKMSAANPERKPKKTPTALELLHAQTVSQAAAS
SPQDAYKSPHSPYYQLPPKVQRHSSNQLLATPTPPALQKLLESFKVQYLQFLAYMKTPQY
KANLQQLVEQEKEKNTQLLGTAQQLFSHCQAQKEEIKRLFQQKLDELGVKALTYNDLIQA
QKEISAHNQQLKEQTKQLESDNSELRNQSLQLLKARCEELKLDWSTLSLENLLKEKQALK
NQISEKQKHCLELQISIVELEKSQRQQELLQLKSYAPADEALSVHLRSKSSFSRELETDP
ARFQLELECSKLSLPHINSMSPELSMNGHATTYEIHSMLSRPSSKQNTPQYLTSHLDQEI
VPCTPIHNNRQKADKLSSLSLPDYTRFSPAKLALRRHLNQDHVVHGKATTNEIHHRTEHA
KENGLTYQSAGLSNGLKLSPQETRPSSPSALQIAGEKSSDKVLKERAYASNGETITSLPI
SIPLSTVQPNKLPVSIPLASVVLPSRAEKVRNTPSPVHQNRESTSATLEKQFGANSHNGM
NSAVGNKSLALATSGFSYSGSLAVNGTLSSSPAHLNHGAEQAALDDSSNSGSLFNSVGSR
SSTPQHPSLLMMQSRNSGQNSPAHPLAASPRLNGASQSMLGILQYSDTTKLFSEGNKGDL
PLDSGFSDPESEVKRRILFTISTNTGNLKQSPSNKHSPLTTSIRPDCGQACVQEGKKRGR
RKRSSTGNPSVNSAVSPKRKPLPSVAGLFTQSSGSPLNINSMVNNINQPLEITAISSPEN
SLKNSPIPYQDNDQPPVLKKEKPLIQTNGAHYSPLTSDEEQGSEDEHNSIRIERKIATIS
LESKSPQKTENGGGLTGRKQTQLTEGINSSKWKSTFSPISDINLTKTSDSPLQAASSLSQ
NSLFAFRPSSEDTMAIDAKISVHPRKSFPSSLSGSDGLSPNTNSSNGFSYTGGLSAADMS
LHSFHDGASLSHKTTEAAGLSSPLGFQAQRSKDASDANPFLNKRQLDGLGSMKGEELPRA
GGRSKEVLDMALQLGGPPDKGSLQHIGKAGKGRDREVEFKNGHNLFISAAAAVPPGGLLN
GKGLSSTASVVGHPASSVSAHHPFLNTFTTGSQFPLGPMSLQANXXXXXXXXXXXXXXXX
MPAAASLVHVSSAATRLTNSHAMGNFSSGVTGGTVGGVFNHAVPSASSHQFGASFSSSAV
CSSTMLSLNPVQAVVTPTSSSFQAPSSSIGTCSEARAPQHLNQVPVQPALHPPPPAPPPP
NVSLPPPPPLLTASNPEPGLLQTLTSIPANKAFVAPSSAASLQANASLSIKLASLPHKAS
RPSFTVHHQPLPRLALAQAAPAVPQSDAAGPPAMWVTLGMQSPYASHLSGVKPR |
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| NT seq |
5205 nt  +upstreamnt +downstreamnt
atgtggttagacatgctgaagaaaaactactttggcagctgcagatgggtctgcgaagaa
ataccagatctcaagcttgccatggaaaattatgttttaattgactatgataccaaaagc
tttgaaagcatgcagagactctgtgacaagtacaaccgagccattgatagcattcatcaa
ctgtggaaaggaacaactcagcccatgaaattgaacactcggccatccaatgggcttctt
cgacatatcttgcagcaagtatataaccactcagtcacagatccagagaaactcaacaac
tatgagcccttttctccagaggtgtatggagaaacttcattcgacttagttgcccaaatg
attgatgagattaaaatgacagaggatgatttgtttgttgatttgggcagtggagtgggg
caggtggttttgcaagtggctgcagccacaaattgtaaacatcactatggtgtggagaaa
gcagacatcccggcaaaatatgctgagacaatggaccgagaattcagaaaatggatgaaa
tggtatgggaagaagcatgcagaatacacactggaaagaggtgacttcctttcagaagaa
tggcgggaaagaattgcaaatacaagtgttatttttgtgaataattttgcctttggtcct
gaggtggatcaccaactgaaggagcgatttgctaacatgaaagaaggtggcagaattgtg
tcctccaaaccttttgcacctctaaattttagaataaacagtagaaacttgagtgatatt
ggcactataatgagagttgtggaactatcaccactgaaagggtcggtttcatggactggc
aagccagtttcttactacctgcatactattgatcgaaccatacttgaaaactatttttct
agtctcaaaaatccaaaactcagggaggagcaggaggcagcccgccgccggcaacaaaga
gagaacaagagcaacacgacgactcccaccaaggtccaagaaaataagggtgctgttgct
ttggagcctcgagtggattctggtgctgaagaagataaaaatgggacaactactcttaaa
aaaccatctccttccaagcctcgcaaaaagaaattaaacaaaaaaggaaggaagatggca
ggaagaaaacgtggacgtcccaagaaaatgagtgctgcaaaccctgaaaggaaacccaag
aagactcccactgcactggagcttctgcatgctcagactgtgtcccaggcagctgcatcc
tctcctcaggatgcatacaagtcacctcatagtccatactatcaactacctcctaaagta
caacggcattcctccaaccagctattggcaacaccaaccccacctgcactccagaagctg
ttagaatcctttaaggttcagtacttgcagtttctggcctatatgaaaaccccacagtac
aaagctaacctacagcaattggtggagcaggagaaggaaaagaacactcaattgttaggt
acagcccagcagttgttcagccactgtcaggctcagaaagaggagatcaagagactgttt
cagcagaaacttgatgagttgggagttaaggctctgacctacaatgatctgatacaagct
cagaaagagatctctgctcacaaccaacagctaaaagaacagacaaagcagctagaaagt
gataacagtgaactcaggaatcaaagcttgcagctgcttaaggctcggtgtgaagagctg
aagctggattggtctactctctcactggaaaatttgctgaaggagaagcaggcactgaag
aatcaaatttccgagaagcaaaagcactgtctggagcttcagatcagcattgtggagctt
gagaaaagccaaaggcagcaggaactactgcagctgaaatcctacgcgccggcagatgag
gccctgtccgtccacctgcgaagtaaaagcagcttcagccgtgagctggagactgaccct
gccaggttccagctggagctcgagtgctccaagttgtctttgccccacatcaatagcatg
agccccgaactttctatgaatggccatgcaaccacctatgagattcatagtatgcttagt
cgaccttcttccaaacaaaacactccacagtatctgacctcccacctggaccaagaaata
gttccttgcacccccattcataacaacagacagaaggcagacaaattgtcaagcttgtcc
ttgcctgattacaccaggttttcccccgctaagttagccctaaggagacacttgaatcag
gatcatgtagtccatggaaaagctacaactaatgaaatacaccacagaactgaacatgca
aaagagaatggcctgacatatcagagtgctggtctgtcaaatggcctaaagctgagccct
caggaaactcggccttcctccccctcggccttacagattgcaggagagaagagcagtgac
aaggttttaaaagagagagcctatgccagcaatggggaaacaatcaccagcctacctatc
agtattcctctcagtacagtgcagcccaataaacttcctgtcagtatcccattggccagt
gtagtgttgcctagccgtgcggagaaagtgaggaacacacctagtccagttcatcagaat
cgagagtctacttcagcaacacttgaaaaacagtttggtgctaattcccataatggtatg
aacagtgctgtaggaaacaagtcccttgctttggctacctcaggtttttcttatagtggc
tccttggcagtcaatggcacactttccagtagcccagcccatcttaaccatggtgctgag
caggcagcccttgatgattcctccaattcagggagcctctttaattcagtggggtcccgg
agttctacgccccagcatccttctttactcatgatgcagtcccggaactctggccagaac
tctccagcccatccacttgctgccagcccgcgcctcaatggagcttctcaaagcatgttg
gggattttgcagtactcggatactacaaaattgttctctgaaggtaacaagggggatctt
ccactagattcaggtttttcagatcctgaaagtgaagtcaagagaagaatcctctttaca
atctcgaccaatacagggaacctgaagcagtctccttccaacaaacacagccctctgacc
actagcattcgcccggattgtggacaggcttgtgtgcaggagggcaagaagaggggcaga
aggaagcggtcttccacggggaaccccagtgtgaactcagcggtatctcccaagcgcaag
cccttaccatctgtggcaggcctttttacccaatcttcaggctcacctctcaacatcaac
tctatggtcaataacattaatcaacctttagaaataacagccatttcctcccctgaaaac
tccctgaagaactctcctattccttaccaggacaacgaccagcctcctgtgctgaaaaag
gagaagcccttgatccagacgaacggggcacattactcgcccctgacctcggatgaagag
caaggatctgaagatgagcacaacagtatcaggattgaaaggaaaatcgcaacaatctct
ttagagagcaagtctccccagaaaacagaaaatggtggtggccttacaggaaggaagcaa
acccagctgactgaaggcataaacagtagtaaatggaagtctaccttttcaccaatatca
gacatcaaccttaccaaaacatccgacagccccttacaggcagcttcgtccctgagccag
aattccctgtttgccttccggccgtcctccgaggacacgatggccattgatgccaagatc
tctgtgcacccaaggaagagcttccccagttccttgtcggggtcggatggtctcagcccc
aacacaaactcctccaatggattctcctataccgggggcctgtctgctgctgacatgagt
ttacacagctttcacgatggtgcttctctttctcacaaaaccaccgaggcggccggccta
agctcccctctgggttttcaggcacagcggagcaaagatgcatcagatgccaatcctttt
ctgaacaagaggcagctggacggcctgggcagtatgaagggagaagagttgccgagggcc
ggaggcagaagtaaagaggtgcttgacatggccctgcagctgggggggccccccgacaaa
ggctccctgcagcacattggcaaggctggcaaagggcgggaccgggaggtggagtttaag
aatggccacaacctcttcatttctgctgcggccgccgtacctccagggggcctcctcaac
ggcaaagggctgtctagcacggcctctgtggttggtcaccctgcttcttctgtatcggcg
caccatcccttcctcaacactttcaccactggatcccagtttcccctgggccccatgtcc
ctgcaggccaaccnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncc
atgcccgccgctgccagtttggtccacgtgtcatcagccgcgaccagattgacaaattct
cacgctatgggaaacttctcttctggggttacaggtggaaccgttggaggtgtttttaac
catgcggtgccttctgcctcttctcatcagtttggagccagtttcagcagtagtgctgtg
tgtagcagcaccatgctaagcttaaacccagtgcaggctgtggtcacccccacttcctct
tccttccaggccccttcctctagcataggaacatgtagcgaggctagagccccccagcac
ctgaaccaagtgcctgtgcagcctgccctgcatcctcctccccccgctcctcctcctcct
aacgtctcattacctcccccccctccattactcactgcttctaacccggagccggggctt
ctgcagaccctaacgtccattcctgctaacaaagcttttgttgccccctcctcagctgct
tctctccaggctaacgcttctctgtctatcaagctggcctccctcccccacaaagcttcc
cgcccctccttcacagtccaccatcagcctctgccccgtttggccctggcccaggctgca
cccgcggtcccgcagtccgacgccgctggcccacccgctatgtgggttacccttggcatg
cagtctccttacgcttcgcacctttctggggttaagccgcgataa |
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