KEGG   Sarcophilus harrisii (Tasmanian devil): 100923119Help
Entry
100923119         CDS       T02286                                 

Gene name
PLCG1
Definition
(RefSeq) phospholipase C gamma 1
  KO
K01116  
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
Inositol phosphate metabolism
Metabolic pathways
EGFR tyrosine kinase inhibitor resistance
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
Phospholipase D signaling pathway
Axon guidance
VEGF signaling pathway
Natural killer cell mediated cytotoxicity
Th1 and Th2 cell differentiation
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Choline metabolism in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:shr00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100923119 (PLCG1)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100923119 (PLCG1)
   04015 Rap1 signaling pathway
    100923119 (PLCG1)
   04012 ErbB signaling pathway
    100923119 (PLCG1)
   04370 VEGF signaling pathway
    100923119 (PLCG1)
   04064 NF-kappa B signaling pathway
    100923119 (PLCG1)
   04066 HIF-1 signaling pathway
    100923119 (PLCG1)
   04020 Calcium signaling pathway
    100923119 (PLCG1)
   04070 Phosphatidylinositol signaling system
    100923119 (PLCG1)
   04072 Phospholipase D signaling pathway
    100923119 (PLCG1)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    100923119 (PLCG1)
   04660 T cell receptor signaling pathway
    100923119 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    100923119 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    100923119 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    100923119 (PLCG1)
   04670 Leukocyte transendothelial migration
    100923119 (PLCG1)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    100923119 (PLCG1)
  Nervous system
   04722 Neurotrophin signaling pathway
    100923119 (PLCG1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100923119 (PLCG1)
  Development
   04360 Axon guidance
    100923119 (PLCG1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100923119 (PLCG1)
   05231 Choline metabolism in cancer
    100923119 (PLCG1)
   05206 MicroRNAs in cancer
    100923119 (PLCG1)
   05205 Proteoglycans in cancer
    100923119 (PLCG1)
   05214 Glioma
    100923119 (PLCG1)
   05223 Non-small cell lung cancer
    100923119 (PLCG1)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    100923119 (PLCG1)
  Infectious diseases
   05169 Epstein-Barr virus infection
    100923119 (PLCG1)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    100923119 (PLCG1)
Enzymes [BR:shr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100923119 (PLCG1)
Membrane trafficking [BR:shr04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100923119 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100923119 (PLCG1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Ensembl: 
Position
1
AA seq 982 aa AA seqDB search
MMAGVGAPFANGCGACAPSEAEALHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQ
ITWSRGADKIEGAVDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKT
LSLQATSEDEVNMWIKGLNWLVTDTVQAATPLQIERWLRKQFYSVDRNREDRISAKDLKN
MLSQVNYRVPNMRFLRERLTDMEQRSGDITYGQFAQLYRSLMFSAQKSMDFPFLEAGTLR
GGDRPELCRVSLSEFQQFLLEYQGELWATDRLQVQEFMLSFLQDPLREIEEPYFFLDEFV
TFLFSKENNIWNSQLDSVCVDTMNNPLSQYWISSSHNTYLTGDQFSSESSLEAYARCLRM
GCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVTSEYPVILSIEDHCSI
AQQRNMAQYFKKVFGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSV
MYSENDISNSIKNGILYLEDPINHEWYPHYFVLTSSKIYYSEETNSDQGNEDEEEPKEVS
SSAELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSF
WRNGKVQHCRIHSRQDAGSPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLTEPVPQ
TNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRSEPNSYAISFRAEGKIKHCRVQQ
EGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKMGTAEPDYGALYEGRN
PGFYVEANPMPTFKNGRGIVCPFVEIEVAGADYDNMKHKTEFVVDNGLNPVWPAKPFHFQ
ISNPEFAFLRFVVYEEDMFSDQNFLAQATFLVKGLKTGYRAVPLKNNYSEDLELASLLIK
IDIFPAKENGEISPFGSSSFRERGSESSGQLLHGRAREGSFEARYQQPFEDFRISQEHLA
DHFDSRERRALRRTRINGDNRL
NT seq 2949 nt NT seq  +upstreamnt  +downstreamnt
atgatggcaggggtcggggcccccttcgccaatggctgcggggcctgcgctccgtcggag
gccgaggctcttcacctctgccggagtttggaagtgggcacagtcatgaccttgttctac
tccaagaaatcccagcgacctgagaggaaaaccttccaggtcaagttggagacccggcag
atcacgtggagtcgaggggcagataaaatcgagggagcggttgatattcgtgaaatcaag
gagatccggcctgggaaaacctctcgtgattttgaccgttaccaggaggacccggccttc
cggcccgaccagtcccattgctttgttatcctgtacggcatggaattccgcctgaaaacg
ctgagtctgcaagccacctcggaggacgaagtgaatatgtggatcaaaggcttgaactgg
ttggtgactgataccgtgcaggcggccacgcctctgcagatcgagaggtggctccggaag
cagttctactccgtggatcggaatcgggaagacaggatttctgccaaggatcttaagaac
atgctgtcccaggtcaactaccgagttcccaacatgcggttcctgagggaacggttgacg
gacatggagcagcggagtggggacatcacctatggccagtttgcgcagctctaccgcagc
ctcatgttcagtgcccagaaatcgatggactttcctttcctggaagccggcaccctgagg
ggcggggatcgacccgagctctgcagagtttccctgtcggagtttcagcagtttctcctg
gaataccagggggagctgtgggccactgacaggctgcaggtgcaggagttcatgctcagc
ttcctccaagacccgctccgggaaatcgaggagccttacttcttcctggacgagtttgtt
accttcctgttttccaaagagaataacatctggaactcccagctggattcggtgtgtgtg
gacaccatgaacaaccctctgtctcagtattggatctcttcatctcacaacacgtacctg
accggggaccagttctccagcgagtcctccttggaggcctatgcgcggtgcctccggatg
ggctgccgatgcatcgagttggactgctgggatggaccggacgggatgccagtcatttac
catggacacaccctcaccaccaagatcaagttctccgatgttctgcacaccatcaaggag
catgccttcgtgacctcggagtaccccgtgatcttgtccattgaggatcattgcagcatc
gctcagcagagaaacatggcccagtacttcaagaaggtatttggcgacacgcttctcacc
aagcccgtggacattgcggctgatggtctgccttcgcccaaccagctcaagagaaaaatc
cttatcaagcacaagaagctggctgagggcagtgcctacgaggaggtgcccacgtcggtg
atgtactcagagaatgacatcagcaattccatcaagaacggcatcctctatttggaagac
cccattaatcacgagtggtacccgcactactttgtactgaccagcagcaaaatctattac
tcagaggagaccaacagtgaccagggcaacgaggacgaggaggagccaaaggaggtgagc
agcagtgccgagctacactccagcgagaaatggttccatgggaagctaggggccggtcgg
gacgggcgacacatcgccgagcggctgcttaccgagtactgcattgagaccggagccccc
gacggttcctttctggttcgggagagtgagacctttgtcggggactacaccctgtccttc
tggcggaacgggaaggtgcagcactgccggatccactcccgtcaggacgccggcagcccc
aagttcttcctgacagacaacctggtgtttgactcgctctatgacctcatcacccactac
cagcaggtgccgctgcgatgcaacgagttcgagatgcgccttacggagcccgtgcctcag
actaacgcacacgagagcaaagagtggtaccacgccagtctgacccgagcccaggcggaa
catatgttgatgcgggttccccgggacggggccttcctcgtgcgaaagcggagcgagccc
aactcctacgccatctccttccgggcagaagggaagatcaaacattgccgggtccagcag
gaggggcagacggtgatgctggggaactcggagtttgacagccttgtagatctcatcagt
tactatgagaagcatccactgtatcgaaagatgaagctccggtaccccatcaatgaggag
gcattggagaagatgggcacagcggaacctgactatggagctctgtatgaaggacggaat
ccaggtttctatgtggaggcaaatcctatgccaacttttaagaacggccggggcatcgtg
tgtccttttgtggagattgaggtggccggggccgactacgacaacatgaagcacaagacg
gagtttgtggtggacaatggtctgaaccccgtttggccggcaaagcccttccacttccag
attagtaaccccgagtttgctttcctgcgctttgtggtatatgaagaagatatgttcagt
gaccagaatttcttggctcaggccaccttcctggtgaaaggcctaaagacaggatacaga
gcggtgcctttgaagaataactacagtgaggacttggagttggcctctctgcttatcaaa
atagatatatttcctgccaaggagaacggggagatcagtccctttggcagctcgtcgttc
cgagaacggggctccgaatcttctggccagctgctccacggacgggcccgggagggctcc
tttgaagcccgctaccagcagcccttcgaggacttccgcatctcccaggagcacctagca
gaccactttgacagccgggaacgaagggcacttcggagaactcgtatcaatggagacaac
cgcctctag

DBGET integrated database retrieval system