KEGG   Sarcophilus harrisii (Tasmanian devil): 100929015Help
Entry
100929015         CDS       T02286                                 

Gene name
PLCB2
Definition
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
shr00562  Inositol phosphate metabolism
shr01100  Metabolic pathways
shr04015  Rap1 signaling pathway
shr04020  Calcium signaling pathway
shr04022  cGMP-PKG signaling pathway
shr04062  Chemokine signaling pathway
shr04070  Phosphatidylinositol signaling system
shr04071  Sphingolipid signaling pathway
shr04072  Phospholipase D signaling pathway
shr04261  Adrenergic signaling in cardiomyocytes
shr04270  Vascular smooth muscle contraction
shr04310  Wnt signaling pathway
shr04371  Apelin signaling pathway
shr04540  Gap junction
shr04611  Platelet activation
shr04621  NOD-like receptor signaling pathway
shr04713  Circadian entrainment
shr04720  Long-term potentiation
shr04723  Retrograde endocannabinoid signaling
shr04724  Glutamatergic synapse
shr04725  Cholinergic synapse
shr04726  Serotonergic synapse
shr04728  Dopaminergic synapse
shr04730  Long-term depression
shr04750  Inflammatory mediator regulation of TRP channels
shr04911  Insulin secretion
shr04912  GnRH signaling pathway
shr04915  Estrogen signaling pathway
shr04916  Melanogenesis
shr04918  Thyroid hormone synthesis
shr04919  Thyroid hormone signaling pathway
shr04921  Oxytocin signaling pathway
shr04922  Glucagon signaling pathway
shr04924  Renin secretion
shr04925  Aldosterone synthesis and secretion
shr04926  Relaxin signaling pathway
shr04927  Cortisol synthesis and secretion
shr04928  Parathyroid hormone synthesis, secretion and action
shr04933  AGE-RAGE signaling pathway in diabetic complications
shr04934  Cushing's syndrome
shr04961  Endocrine and other factor-regulated calcium reabsorption
shr04970  Salivary secretion
shr04971  Gastric acid secretion
shr04972  Pancreatic secretion
shr05010  Alzheimer's disease
shr05016  Huntington's disease
shr05142  Chagas disease (American trypanosomiasis)
shr05143  African trypanosomiasis
shr05146  Amoebiasis
shr05200  Pathways in cancer
Module
shr_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:shr00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100929015 (PLCB2)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100929015 (PLCB2)
   04310 Wnt signaling pathway
    100929015 (PLCB2)
   04371 Apelin signaling pathway
    100929015 (PLCB2)
   04020 Calcium signaling pathway
    100929015 (PLCB2)
   04070 Phosphatidylinositol signaling system
    100929015 (PLCB2)
   04072 Phospholipase D signaling pathway
    100929015 (PLCB2)
   04071 Sphingolipid signaling pathway
    100929015 (PLCB2)
   04022 cGMP - PKG signaling pathway
    100929015 (PLCB2)
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    100929015 (PLCB2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100929015 (PLCB2)
   04621 NOD-like receptor signaling pathway
    100929015 (PLCB2)
   04062 Chemokine signaling pathway
    100929015 (PLCB2)
  Endocrine system
   04911 Insulin secretion
    100929015 (PLCB2)
   04922 Glucagon signaling pathway
    100929015 (PLCB2)
   04912 GnRH signaling pathway
    100929015 (PLCB2)
   04915 Estrogen signaling pathway
    100929015 (PLCB2)
   04921 Oxytocin signaling pathway
    100929015 (PLCB2)
   04926 Relaxin signaling pathway
    100929015 (PLCB2)
   04918 Thyroid hormone synthesis
    100929015 (PLCB2)
   04919 Thyroid hormone signaling pathway
    100929015 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    100929015 (PLCB2)
   04916 Melanogenesis
    100929015 (PLCB2)
   04924 Renin secretion
    100929015 (PLCB2)
   04925 Aldosterone synthesis and secretion
    100929015 (PLCB2)
   04927 Cortisol synthesis and secretion
    100929015 (PLCB2)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100929015 (PLCB2)
   04270 Vascular smooth muscle contraction
    100929015 (PLCB2)
  Digestive system
   04970 Salivary secretion
    100929015 (PLCB2)
   04971 Gastric acid secretion
    100929015 (PLCB2)
   04972 Pancreatic secretion
    100929015 (PLCB2)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100929015 (PLCB2)
  Nervous system
   04724 Glutamatergic synapse
    100929015 (PLCB2)
   04725 Cholinergic synapse
    100929015 (PLCB2)
   04728 Dopaminergic synapse
    100929015 (PLCB2)
   04726 Serotonergic synapse
    100929015 (PLCB2)
   04720 Long-term potentiation
    100929015 (PLCB2)
   04730 Long-term depression
    100929015 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    100929015 (PLCB2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100929015 (PLCB2)
  Environmental adaptation
   04713 Circadian entrainment
    100929015 (PLCB2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100929015 (PLCB2)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100929015 (PLCB2)
   05016 Huntington's disease
    100929015 (PLCB2)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    100929015 (PLCB2)
   04934 Cushing's syndrome
    100929015 (PLCB2)
  Infectious diseases
   05146 Amoebiasis
    100929015 (PLCB2)
   05142 Chagas disease (American trypanosomiasis)
    100929015 (PLCB2)
   05143 African trypanosomiasis
    100929015 (PLCB2)
Enzymes [BR:shr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100929015 (PLCB2)
Membrane trafficking [BR:shr04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100929015 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100929015 (PLCB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PLC-beta_C PI-PLC-X PI-PLC-Y EF-hand_like C2 DUF1154 MMACHC
Motif
Other DBs
NCBI-GeneID: 100929015
NCBI-ProteinID: XP_012401667
Ensembl: ENSSHAG00000013405
UniProt: G3WJX3
Position
1
AA seq 1211 aa AA seqDB search
MSLLSPILLPPEVKSYLTRGERFIKWDDETSVASPVILRVDPNGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKMPKTQKLREVFNLDFPDNTFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVSKDWAEDVLALAKNPLTANAPRSKFLNKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDSINPEDFPEPVYRSFLMNLCPRPEIDEIFTSHHSKAKPYMTKDH
LTKFINQKQRDARLNSLLFPPARPDQVQCLIEKYEPSGINIQRGQLSPEGMVWFLSGPEN
SIVAHDKLILHQDMSQPLNHYFINSSHNTYLTAGQFSGPSSSEMYRQVLLSGCRCVELDC
WKGKPPEEEPIITHGFTMTTDILFKDAVEAIAESAFKTSLYPVILSFENHVDSPRQQAKM
AEYCRTIFGDMLLTEPLDKFPLKPGIPLPSPQDLLGKILIKNKKNQSPGPISPKKELCAE
TEDFNQTNPALGEDTAPIPPKKELCAETEDFNQPNPAMGEDTVWVGEEEAELEEEEEEES
GNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSSQKNRSYVISSFTE
LKAYDLLTKSPVQFVDYNKRQMSRIYPKGTRMDSSNYSPQMFWNAGCQMVALNFQTMDMP
MQQNMALFEFNGQSGYLLKHEFMRRPDKQFDPFSVDRIDVVVATTLSITVISGQFLSERS
VRTYVEVEVFGLPGDPKRRYRTKLTPNANSINPVWKEDPFVFEKIMMPELASLRVAVLEE
GGKFIGHRIIPVHALQSGYHHLCLRSESNIPLTMPALFVFLEMKDYVPDTWADLTVALAN
PIKFFNAQDKKSVKLQDTGDDPPDRLLPLRNSALGQANGTLISAGSSMAPSPNGPAAAVT
WFKEEAMKEAAEPQTASLEELQQLKGFLKLQKRQEKELRELERRGVRRWEELLQKYACLQ
SELTTQGGCRKLSVTKGSRKKRNLPWEDTREAGQGPMEGPESIDGRIRELKEKLETELYQ
QGEEQYESIMKRKEQHGTEQIAKVMELAQERQAVELKALKESAESNTKEMKKKLEVKRLE
RIQAMSKITSDKMAQERLKREINNSHIQEVVHIIKQMTETLERHQERLEEKQAACLEQIR
EKEKKFQQEALSEYEEQMKGLEAKVKEAVRCCLSFPQDDQDKKLEIPSVVEEPSEETSCP
NEASSQLDSRL
NT seq 3636 nt NT seq  +upstreamnt  +downstreamnt
atgtctttgctcagcccaatcctgctgccccctgaggtgaagagctatctaacccgagga
gagcgcttcatcaaatgggatgatgagacttctgtggcatctccagtcatcctccgagtg
gatcccaatggctattacttgtactggacatatcaaagcaaggagatggagttcctggac
atcaccagtattcgggatactcgttttgggaagtttgctaagatgcccaagacccagaag
cttcgggaggtattcaacttggacttccctgacaacaccttcttgctgaagacgctgact
gttgtgtctggcccagatatggtagacctgaccttccataactttgtctcctacaaagag
aatgtcagtaaggattgggctgaagatgttctggccttggctaaaaacccattaacagcc
aatgccccccggagcaagttcctgaataagatcctagtaaagctcaagatgcagctcaat
ccagaaggaaagatccctgtaaagaattttttccagatgtttcctgctgaccggaaacga
gtagaggctgctctcagtgcctgtcaccttcccaagggcaaaaatgattccatcaaccct
gaggatttccctgaacctgtctacaggagttttctcatgaatctatgtccacgacctgaa
attgatgaaatctttacttctcatcattccaaagcaaagccttacatgaccaaggaccat
ctgaccaagttcattaaccaaaagcagcgggatgcccggctcaactccttactcttccca
ccagcccgacctgaccaagtacaatgcctcattgaaaagtatgagcctagtggcatcaac
atccagaggggtcaactctcaccagagggcatggtttggttcttgagtggtcctgagaac
agcatagtagcccacgacaagctgatactgcaccaggacatgagccagcctctgaatcac
tacttcatcaattcctcccacaacacctacctgacagctggtcagttctcaggaccctca
tcctcagagatgtacagacaggtcttgctctctggctgccgctgcgtggagcttgactgc
tggaagggaaagcctcctgaggaagagccaatcatcacccatggcttcaccatgaccaca
gatattttatttaaggatgcagtagaggctattgctgagagtgccttcaagacctcactc
taccctgtcattctgtcctttgaaaaccatgtagattcgccccgacaacaggccaaaatg
gcagagtactgtcggaccatatttggggacatgctcctcactgagcccctggataagttc
cctttgaagccaggaatccccctccccagtcctcaggaccttctgggtaagatccttatc
aagaataagaagaatcaatccccaggtcccatttcacccaagaaggaattgtgtgcagag
acagaggacttcaaccagactaatccagccttgggtgaggacacagctcccattccaccc
aagaaagaactgtgtgcagagacagaggacttcaaccaacccaatccagccatgggtgag
gacacagtatgggtaggtgaagaagaagctgagttagaggaagaagaagaggaagaatca
ggtaacttggatgaagaggaaataaagaagatgcaatctgatgagggcacagctggcctg
gaggtgacagcctatgaagagatgtctagtctggtcaactatatccaacctaccaagttc
atttctttcgagttctcctctcagaagaatcggagttatgtcatctcttccttcacggag
ctgaaagcttatgacctgctcaccaagtccccggtgcagtttgtggactacaataagcgc
caaatgagtcggatctaccctaagggtacccgaatggactcatctaactactctccccag
atgttctggaatgcaggctgtcaaatggttgccctcaatttccagactatggatatgcct
atgcagcagaacatggcactgtttgagttcaatggacagagtggctaccttctcaagcat
gagttcatgcgccgaccagacaagcaattcgaccctttctctgtggaccgcatcgatgtg
gtggtggccacaactctctccattacggtgatttctggtcagtttctgtcagaacgaagt
gtccgaacttatgtggaggtggaggtgtttggcttgcctggagaccccaaaagacgttac
cgcaccaaactgacacccaatgccaattccataaatcccgtctggaaagaggaccccttt
gtctttgaaaagatcatgatgccagaactggcctctctgagagtggcagtactggaggaa
ggaggcaaattcattgggcaccgaattatccctgtccatgccctgcagtcaggataccac
cacttgtgcctcaggagcgagagcaacattcccctcactatgcctgcactctttgttttc
ctggaaatgaaagactatgtgcctgatacctgggcagatctgactgtggctcttgccaac
cccatcaaattcttcaatgcacaagacaagaaatcagtaaagctgcaggacactggggat
gacccccctgacaggcttttgccactcagaaactctgctctgggccaggccaatgggacc
ctcatctctgcaggttcctctatggccccatcacccaatggtcctgcagcagctgtgacc
tggttcaaggaagaagcaatgaaagaggcggcagaacctcagacagccagcctggaggag
ctacagcagttgaaagggttcctgaagcttcagaaaagacaggaaaaggagcttcgggaa
ctggaaagacggggagtccggcgctgggaagaactcctgcaaaaatatgcctgcttacag
tctgaactgaccacccaaggtggatgcaggaagttgtctgtcacaaagggatcccggaag
aagagaaacttgccttgggaggacacccgtgaggctgggcaggggccaatggaggggcca
gaaagtatagatggacgtattcgagagctgaaggagaagctggagacagaattgtaccag
caaggagaggagcagtatgaaagcatcatgaaacgcaaggaacagcatggcacagagcaa
atcgccaaagtgatggagctggcccaggagagacaagctgttgagcttaaagctctcaag
gagtctgcagaaagcaacaccaaagaaatgaagaagaagcttgaagtcaaaaggctagaa
cggattcaggccatgagcaagatcaccagtgacaagatggcccaggagagactgaagaga
gaaattaacaactcacatatacaggaagtggttcacatcatcaaacagatgacagagacc
ctggagagacaccaggagaggctggaagaaaaacaggcagcttgcttggagcagattagg
gagaaggagaaaaagttccagcaagaggcactgtctgaatatgaggagcagatgaagggc
ctggaagctaaggtgaaggaggcggtgagatgctgcctcagtttcccccaagatgaccaa
gacaagaagctggagatccccagtgttgtagaggaaccttcagaggagacatcttgccca
aacgaagcttcttcccagctagatagccgtctctaa

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