KEGG   Sarcophilus harrisii (Tasmanian devil): 100931480Help
Entry
100931480         CDS       T02286                                 

Gene name
MTOR
Definition
mechanistic target of rapamycin (serine/threonine kinase)
Orthology
K07203  
FKBP12-rapamycin complex-associated protein
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
ErbB signaling pathway
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Insulin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:shr00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    100931480 (MTOR)
   04066 HIF-1 signaling pathway
    100931480 (MTOR)
   04151 PI3K-Akt signaling pathway
    100931480 (MTOR)
   04152 AMPK signaling pathway
    100931480 (MTOR)
   04150 mTOR signaling pathway
    100931480 (MTOR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    100931480 (MTOR)
   04920 Adipocytokine signaling pathway
    100931480 (MTOR)
   04919 Thyroid hormone signaling pathway
    100931480 (MTOR)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100931480 (MTOR)
   05206 MicroRNAs in cancer
    100931480 (MTOR)
   05205 Proteoglycans in cancer
    100931480 (MTOR)
   05214 Glioma
    100931480 (MTOR)
   05221 Acute myeloid leukemia
    100931480 (MTOR)
   05215 Prostate cancer
    100931480 (MTOR)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100931480 (MTOR)
Protein kinases [BR:shr01001]
 Serine/threonine protein kinases: Atypical group
  PIKK family [OT]
   100931480 (MTOR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
3
AA seq 2325 aa AA seqDB search
MSGTVTILQQFASGLKSRSEETRAKTAKELQHYVTLELREMSQEESTRFYDQLNHHIFEL
VSSSDANERKGGILAIASLIGVEAYATRIGRFANYLRNLLPSNDPVVMEMASKAIGRLAM
AGDTCTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDTIF
VAVWDPKQAIREGAVSALRACLILTTQREPKEMQKPQWYRHTYEEAEKGFDETLAKEKGM
NRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITP
FTSFQAVQPQQSNALVGLLGYSAHQGIMGFGASPLPAKSTLVESRCCRDLMEEKFDQVCQ
WVLKCRSSKNSLIQMTILNLLPRLAAFQPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQ
ALGLLSVAVRSEFKVYLPRVLEIIRAALPPKDFAPKRQKAIQVDATVFTCISMLARAMGP
GIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHP
GMPKGLAHQLASPSLTSLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEH
KEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCV
LASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLI
QILTELEHSGVGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVI
NNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQAIRVLGLLGALDPYKHK
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDAAIREFLFQQLGMLV
SFVRSHIRPYMDEIVTLMREFWVMNSSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
LFMHDSSPGRTVSIKLLNAIQLFGANLDDYLHLLLPPIVKLFDAPDVPLAARKAALETVD
RLTESLDFTDYASRIIHPIVRTLDLSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
RHRINHQRYDMLICRIVKGYTLADEEEDPLIYQHRMMRSNQGDALASGPVETGPMKKLHV
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMASPLPLR
DDNGIVLLGERAAKCRAYAKALHYKELEFQKGPSPAILESLISITSRLKQPMAAXGSLVS
SVDHLGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQ
QCCEKWTLVNDEIQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQD
LFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREII
RQIWWERLQGCQRIVEDWQRILMVRSLVVNPHEDMRTWLKYASLCGKSGRLALAHKTLVL
LLGVDPSRQLDHPLPTVHPQVTYAYMKHMWKSARKIDAFQHMQHFVQTAQQQAQHAIAAE
DQQRKHELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSASTEHDRSWYKAWHAWAV
MNFEAVLHYKHQNQARDEKKKLRHASGASVTSAHTEGSNSESEAESADNSPVPSPVQKKV
TEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKA
IQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHN
AANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFE
VLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFR
RISKQLPQLTSLELQYVSPKLLMCRDLELDVEHGYRVRGAPAKPASGLRVTVLSSGASAS
TAVSFQMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSL
AVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLT
NAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGTKRSRT
RTDSYSAGQSVELLDSVDLGETTHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRV
RDKLTGRDFSHDETLDVPTQVELLIKQATSHENLCQCYIGWCPFW
NT seq 6978 nt NT seq  +upstreamnt  +downstreamnt
atgtcgggcaccgtgaccatcctccagcagtttgccagtggcttgaagagccgcagcgag
gagacgcgggccaaaactgccaaggagctgcagcattatgtcaccctggaactccgggag
atgagtcaggaggagtctacccggttctatgatcagttgaatcatcacatttttgaactg
gtgtccagctcagatgccaatgagcggaaagggggcatcctggccatagccagccttata
ggagtggaagcatatgctacccgcataggcaggtttgctaactaccttcggaacctcctt
ccctccaatgacccagttgtcatggagatggcatccaaggccatcggccgcctggccatg
gcgggagacacttgcacagctgagtatgtggagtttgaggtgaaacgggccctcgaatgg
ctgggtgccgaccgcaacgagggccggagacatgcagctgttcttgtccttcgtgagctg
gccatcagcgtccccaccttcttcttccagcaagtgcagcctttctttgatactatcttt
gtggcagtctgggaccccaaacaggccatccgggaaggagctgtctctgccctccgagcc
tgtctgatcctcaccacccagcgtgaaccgaaagagatgcagaaaccccagtggtacagg
cacacctatgaagaagcagagaagggctttgacgagacactggccaaggagaaaggcatg
aatcgggacgaccggattcatggggccttgctgattctcaatgagcttgtgaggatcagc
agcatggagggagagcgtctccgggaagaaatggaagaaataacccagcagcagctagtg
catgacaagtactgcaaagacctcatgggctttgggacaaaacctcgtcacatcactccc
ttcaccagcttccaggcagtgcagccccagcagtccaatgccctggtcggcctgctgggt
tacagtgcccaccaaggcattatgggatttggggcgtctcccctcccagccaaatccacc
ttggtggaaagccgatgttgcagagacctgatggaagagaaatttgatcaggtgtgccag
tgggtgctaaaatgccggagcagcaagaactccctcatccagatgaccatccttaatctg
ttgccccgcctggctgcgtttcagccatctgccttcactgatactcagtacctccaggac
accatgaaccatgttcttagttgcgtcaagaaggagaaggaacgcacagctgcttttcag
gccctcggcttgctctctgtggccgtgagatccgagtttaaggtctatttgcctcgtgtt
ctggagatcatccgagcagccctcccacccaaggactttgctcctaagaggcagaaggcc
attcaggtggatgccacagtcttcacctgtatcagcatgctggcccgagccatggggccc
ggcatccagcaggacatcaaggagctcctcgagcctatgctggctgtgggcctgagccct
gccctgactgctgtgctctatgacctgagccggcaaattccacagctgaagaaagacatc
caggatggcctgctcaagatgctgtccctggtgctcatgcacaaacccctccggcacccc
gggatgcccaagggcctggcccaccagttggcctcccctagcctcaccagccttccagag
gccagcgacgtagggagcatcactcttgccctgcgaacccttggtagctttgaatttgaa
ggccactctctgacccagtttgtccgccactgtgccgaccattttctgaacagcgagcac
aaggagatccgcatggaggctgcccgcacctgctcccgcctgctcacgccctccatccac
ctcatcagcggccacgcccacgtggtcagtcagacggctgtgcaggtggtagcggatgtg
ctcagcaaactgctggtggttggaataacggacccagaccctgacatccgttactgtgtc
ctggcctccctggatgagcgctttgatgctcacttggcccaggcagagaacctgcaagcc
ttgtttgtggccctgaatgaccaggtgtttgagatccgggagctggccatctgcaccgtg
ggccgcctcagcagcatgaaccctgcttttgtcatgcctttcctgaggaagatgctcatt
cagattttgaccgagctggaacacagtggagttggaagaatcaaggagcagagtgcccga
atgctggggcacttggtttccaatgccccccggcttattcgtccctacatggagcccatt
ctgaaggctttaattctgaagctgaaagatccagaccctgacccaaacccaggggtgatc
aataatgtcttggctacgataggagaactggcacaggtgagtggcctggaaatgcggaag
tgggtggatgagctctttatcatcatcatggacatgctgcaggactcttctcttctggcc
aagaggcaggctatccgagttttggggcttttgggtgctttagatccctacaagcacaaa
gtcaacatcggtatgattgatcagtctcgggatgcttctgccgtcagtttatctgagtcc
aagtccagccaggattcctccgactacagcaccagtgagatgctggtcaacatggggaac
ctgcctcttgatgagttctacccagccgtgtcgatggtggctctgatgaggatcttccgt
gaccaatccctctcccaccatcacaccatggtcgttcaggccatcactttcatctttaaa
tccctggggctcaagtgcgtccagttcctgccccaggttatgcccacgttcctcaacgtg
atccgagtctgtgatgctgccattcgggaatttctgttccagcagctggggatgctagtg
tcctttgtgaggagtcacatcaggccttacatggacgagatcgtcaccctcatgagagag
ttctgggtcatgaacagctccatccagagcacgatcatcctccttattgagcagattgtg
gtcgctctgggtggtgaattcaagctctacttgccccagctgattcctcacatgctgcgg
ctcttcatgcatgacagcagccctggacgcacggtctccatcaagttgttgaacgcaatt
cagctgtttggcgccaatctggatgactacctgcatttgctcttgcctccgattgtgaag
ctctttgatgctcctgatgttccattagcagcacgcaaggcagccttggagactgttgat
cgcttgaccgaatctctggatttcactgattacgcatcccgaatcatccaccccattgtg
cggacactggacctgagcccagagctgcgctccacagccatggacacattgtcttctctt
gtgttccagctggggaagaagtaccagatttttatcccaatggtgaataaagtgctggtg
agacacagaatcaaccatcagcgctacgacatgctcatttgtaggatcgtcaagggctat
acactagctgatgaggaagaagatcccttaatttatcagcaccgaatgatgaggagcaac
cagggcgacgccttggccagtgggccggtcgagacagggcccatgaagaagctgcatgtg
agcaccatcaacctgcagaaggcctggggagcagccaggagggtttccaaggatgattgg
ctggagtggctgagacggctgagcttggaattgctgaaggactcctcatctccgtccctc
cgctcctgctgggccttggctcaggcctacaaccctatggcgagtccgctgcctctccga
gatgacaatggcatcgtgctgctgggtgagcgagcggccaagtgccgcgcctatgccaaa
gcgttacactacaaggagctggagttccagaagggccccagccccgccatcctcgagtct
ctcatcagcattaccagtagactcaaacaaccaatggcagcctgaggatcactggtttct
tctgtggaccacctgggagaacttgagatccaggctacctggtatgaaaagcttcacgaa
tgggaagatgctctggtcgcttatgacaaaaagatggacacaaacaaagatgaccctgag
ttaatgctgggccggatgcgctgcctggaggccttgggagaatgggggcagctccatcag
cagtgctgtgaaaagtggaccctggtcaacgatgagatacaagctaaaatggcccgcatg
gctgctgcagctgcttggggtttaggtcaatgggacagcatggaggagtatacctgtatg
atccctcgggacacccatgatggggctttttacagagccgtgctggccctgcatcaggac
ctcttctcattggctcaacagtgcatcgacaaagccagggacctgctggatgctgagcta
acggccatggcgggagaaagctacagccgagcctatggggcaatggtttcctgtcatatg
ctctcggagctggaggaagttatccagtataaacttgtccccgaacggcgcgagatcatc
cgccagatctggtgggagaggctgcagggctgccagcggattgttgaagattggcagaga
atcctcatggtgcggtctctcgttgtcaacccccatgaagatatgagaacttggcttaaa
tatgcaagtttatgtggcaagagtggaagattggcacttgctcataaaactttagtattg
ctcctgggagttgacccttctcgacaactagaccatccactgccgactgtccatcctcag
gtgacttatgcctacatgaagcacatgtggaagagtgcacgaaagattgatgccttccag
cacatgcagcactttgtgcagactgcccagcaacaggcgcagcacgccatcgctgccgag
gaccagcagcgcaagcacgagctccacaagctcatggcccggtgcttcttgaagctgggt
gaatggcagctgaatctccaaggcatcaacgagagcaccatccccaaggtcttgcagtac
tacagtgcttccacggagcacgaccgcagctggtacaaggcctggcacgcctgggcggtc
atgaactttgaagccgtgctgcactacaagcaccagaatcaggcccgagacgagaagaaa
aagctccgtcatgccagtggggccagtgtcacaagtgcccacacagagggcagcaacagc
gagagtgaggcagagagcgccgacaacagccctgtgccctcacctgtgcagaaaaaggtc
accgaggatctgtccaagacgctcctgatgtacacagtgcctgcagtgcagggcttcttc
cgctccatctctctgtcccggggcaacaaccttcaggacaccctcagagtcctcaccttg
tggtttgactacggacactggccagacgtaaatgaagctcttgtggaaggggtgaaggca
atccagattgatacgtggttgcaggtcatcccacagctcattgcaagaatcgacactccg
cggcccttggtgggacgccttattcatcagctgctcacagacatcggtcgctaccatccc
caggctctgatttaccccctaactgtggcctccaagtccactaccacggcccgccacaat
gcagccaacaagatcctgaagaacatgtgtgagcacagcaacaccctggtccagcaggcc
atgatggtgagcgaagagctgatccgtgtggccatcctgtggcacgagatgtggcacgag
ggtctggaggaagcttctcgtttgtacttcggggagaggaacgtgaaagggatgttcgag
gtgcttgaacccctgcatgcaatgatggagcggggtccccagactctgaaggaaacctcc
tttaatcaggcgtatggccgagatttaatggaggcccaagaatggtgtcggaagtacatg
aagtcagggaatgtcaaggacctgacccaggcgtgggacctctattatcacgtgttccga
cggatctccaagcaactgcctcagctcacttccctggagctgcagtacgtctcccccaag
ctcctgatgtgccgggacctggaactggatgtggagcacggttacagggttagaggagcc
cctgcgaagcccgcgtccgggctccgtgtcactgtcctgtcatctggggcttcagcaagc
acggctgtctcgtttcagatggctccggactatgaccacttgactctgatgcagaaggtg
gaagtgtttgagcacgcagtcaacaacactgccggggacgacctggccaaactgctctgg
ctgaagagccccagctccgaggtgtggtttgaccgaagaaccaactatacccgctcttta
gctgtcatgtcaatggttgggtacattttgggcctgggagacagacacccatccaacctg
atgctggacaggctcagtgggaagatcttacacatcgactttggggattgctttgaggtg
gcaatgactcgagagaagttccctgagaagattccatttagattgacaaggatgctgacc
aatgcaatggaggtgaccggcctcgacggcaactaccggatcacctgccacacagtgatg
gaagttcttcgggaacacaaggacagtgtgatggccgtgttggaagcctttgtgtatgat
cccttattgaactggaggcttatggacacaaatacgaaaggcactaagcgatcacgaacg
cggacagactcctactcagctggccagtctgtagaattactggacagcgtggatcttggg
gagaccacccataagaaaacggggaccacagtgcccgagtccatccattcttttatcggg
gatggtttggtgaaacccgaggccctcaataagaaggcaattcagattattaacagggtt
cgagataagctcacaggtcgagatttttctcatgatgaaactttggacgttcctacacaa
gttgagctactgatcaagcaggccacgtcccacgagaacctctgccagtgctacatcggc
tggtgtcctttctggtaa

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