KEGG   Sarcophilus harrisii (Tasmanian devil): 100932099Help
Entry
100932099         CDS       T02286                                 

Gene name
PIK3CA
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:shr00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100932099 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100932099 (PIK3CA)
   04015 Rap1 signaling pathway
    100932099 (PIK3CA)
   04012 ErbB signaling pathway
    100932099 (PIK3CA)
   04370 VEGF signaling pathway
    100932099 (PIK3CA)
   04630 Jak-STAT signaling pathway
    100932099 (PIK3CA)
   04668 TNF signaling pathway
    100932099 (PIK3CA)
   04066 HIF-1 signaling pathway
    100932099 (PIK3CA)
   04068 FoxO signaling pathway
    100932099 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    100932099 (PIK3CA)
   04024 cAMP signaling pathway
    100932099 (PIK3CA)
   04022 cGMP - PKG signaling pathway
    100932099 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    100932099 (PIK3CA)
   04152 AMPK signaling pathway
    100932099 (PIK3CA)
   04150 mTOR signaling pathway
    100932099 (PIK3CA)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100932099 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    100932099 (PIK3CA)
  Cellular commiunity
   04510 Focal adhesion
    100932099 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100932099 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    100932099 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    100932099 (PIK3CA)
   04660 T cell receptor signaling pathway
    100932099 (PIK3CA)
   04662 B cell receptor signaling pathway
    100932099 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    100932099 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    100932099 (PIK3CA)
   04670 Leukocyte transendothelial migration
    100932099 (PIK3CA)
   04062 Chemokine signaling pathway
    100932099 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    100932099 (PIK3CA)
   04915 Estrogen signaling pathway
    100932099 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    100932099 (PIK3CA)
   04917 Prolactin signaling pathway
    100932099 (PIK3CA)
   04921 Oxytocin signaling pathway
    100932099 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    100932099 (PIK3CA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100932099 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    100932099 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100932099 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    100932099 (PIK3CA)
   04722 Neurotrophin signaling pathway
    100932099 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100932099 (PIK3CA)
  Development
   04380 Osteoclast differentiation
    100932099 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100932099 (PIK3CA)
   05205 Proteoglycans in cancer
    100932099 (PIK3CA)
   05203 Viral carcinogenesis
    100932099 (PIK3CA)
   05210 Colorectal cancer
    100932099 (PIK3CA)
   05212 Pancreatic cancer
    100932099 (PIK3CA)
   05214 Glioma
    100932099 (PIK3CA)
   05221 Acute myeloid leukemia
    100932099 (PIK3CA)
   05220 Chronic myeloid leukemia
    100932099 (PIK3CA)
   05218 Melanoma
    100932099 (PIK3CA)
   05211 Renal cell carcinoma
    100932099 (PIK3CA)
   05215 Prostate cancer
    100932099 (PIK3CA)
   05213 Endometrial cancer
    100932099 (PIK3CA)
   05222 Small cell lung cancer
    100932099 (PIK3CA)
   05223 Non-small cell lung cancer
    100932099 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100932099 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100932099 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    100932099 (PIK3CA)
   05166 HTLV-I infection
    100932099 (PIK3CA)
   05162 Measles
    100932099 (PIK3CA)
   05164 Influenza A
    100932099 (PIK3CA)
   05161 Hepatitis B
    100932099 (PIK3CA)
   05160 Hepatitis C
    100932099 (PIK3CA)
   05169 Epstein-Barr virus infection
    100932099 (PIK3CA)
   05146 Amoebiasis
    100932099 (PIK3CA)
   05145 Toxoplasmosis
    100932099 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    100932099 (PIK3CA)
Enzymes [BR:shr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100932099 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
3
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDETSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDVHAPHSRALYVYPPNVESSPELPKH
IYSKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEHVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYLLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYTQLPLD
TFTMPSYSRRISTATPYMNGEASTKSLWGVNSALRIRILCATYVNVNIRDIDKIYVRTGI
CHGGEPLCDNVNTQRVPCSNPRWNEWLMYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SNPVKFPDMSVIEEHANWTVSRELGFNYSHAGLSNRIARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVNIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRAFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDYMDALQGFISPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccaagaccatcatccggtgaattatggggcatccatttgatgcccccaagaatc
ttagtagaatgtctactacctaatggaatgatagtgactttagaatgcctccgtgaggct
acattagtaactattaaacatgagctatttaaagaagcaaggaaataccctcttcaccag
ctccttcaggatgaaacttcttacattttcgtaagtgttactcaagaagcagaaagagaa
gaattttttgatgaaacacggcgactttgtgacctgcggctttttcagccctttctgaaa
gtcatcgaacctgtaggaaaccgagaagaaaaaattctcaatcgagaaatcggttttgct
attggtatgcctgtttgtgaatttgacatggttaaagatccagaagtgcaagacttccga
agaaatattcttaatgtttgtaaagaagctgtggacctgagggatgtccatgcaccccat
agtagagcattatatgtttatcctccaaatgtagaatcttcaccagaattgccaaagcac
atatacagtaaattagataaagggcaaataatagtggtgatttgggtgatagtttcccca
aacaatgacaagcaaaagtacactttaaaaatcaatcacgactgtgtaccagaacatgtg
atcgctgaagcaatccggaaaaaaacacggagtatgttactatcatctgagcagctgaag
ctctgtgttttagagtatcagggcaaatatattttaaaagtgtgtggatgtgatgagtat
ttgctagaaaaatatcctcttagccaatataagtacataagaagctgtataatgcttggt
cggatgcccaatctgatgctgatggctaaagaaagtctttacacccagctaccactggat
acttttacaatgccatcttattccaggcgaatctctacagccacaccgtacatgaatgga
gaagcttcaaccaaatccctttggggcgtaaatagtgcactccgcataagaattctttgt
gcaacttatgtaaatgtaaatattcgagacattgacaagatctatgttagaacaggtatt
tgccatgggggtgagccattatgtgacaatgtgaatactcagagagtaccttgttccaat
cccaggtggaatgaatggctaatgtatgatatatacattcccgatcttccacgtgctgct
cgactttgcctttccatttgttctgttaaaggcaggaaaggagcaaaagaggaacattgc
ccattggcttggggaaatattaacctctttgattatacagacactctggtatcaggaaaa
atggctttgaatctgtggccagtacctcatggattagaagacttgctgaatcctattgga
gttactggatcaaatcccaataaggaaactccatgtttagagctggaatttgactggttt
agcaatcctgtaaagttcccagatatgtcagtaattgaagaacatgcaaattggactgta
tctcgagaactaggattcaactattcccatgctggactgagtaataggatagctcgagat
aatgaattgagagaaaatgacaaagaacagctccgggcgatttgtacacgagaccctctg
tctgagatcactgagcaagaaaaggacttcctgtggagtcataggcattattgtgtcaat
ataccagaaattctacctaaactacttctgtctgttaagtggaattctagagatgaagta
gcccagatgtattgcttggtaaaagattggcccccaatcaaaccagaacaggccatggaa
cttttggactgtaattatccagaccctatggttcgagcttttgctgttcgatgcttggag
aaatatttaactgatgacaaactttctcaatacttaattcaactggttcaggttctgaag
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcactaacaaat
caaaggatagggcactttttcttttggcatttaaagtctgaaatgcataataaaactgtc
agccagagatttggtttgcttttggagtcatactgtcgagcatgtgggatgtatctaaag
catctgaatcggcaggtagaggccatggagaaactgatcaacctcaccgacattctcaaa
caggagaagaaggatgagacacaaaaggtacagatgaagttcttggttgagcaaatgaga
cgacctgattacatggatgctttacaaggctttatctctccccttaaccctgctcatcaa
ctaggaaatctcaggctcgaagagtgtaggattatgtcttccgcaaaaagaccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactatttcagaacaatgagatcatc
tttaaaaatggggatgacttacggcaggatatgctaacccttcagatcattcggattatg
gaaaatatctggcaaaatcagggtcttgatcttcggatgttaccttatggttgtctatca
atcggggactgtgttggcctcattgaggtggtcagaaattcccacactatcatgcagatt
cagtgtaaagggggcctgaaaggggccttgcagttcaacagccatacgttacatcagtgg
ctcaaagacaagaataaaggagaaatatatgatgcagccattgatttgtttacacgttcc
tgtgctggatactgtgtggctaccttcattttgggaattggtgatcgacacaatagcaat
atcatggtgaaagatgatggacaactattccacatagactttggacactttttggatcac
aagaagaagaaatttggctataaacgagagcgtgtgcccttcgtcttgacgcaagatttc
ttaattgtgattagtaaaggagcccaagaatgtacaaagacaagagagtttgagaggttt
caggaaatgtgctataaggcttacttagctattcgacaacatgccaatctcttcatcaat
ctcttctccatgatgcttggctccggaatgcccgaacttcagtcttttgacgacatcgcc
tatattcgaaagaccctggccttggataagactgagcaggaggctttggagtatttcatg
aagcagatgaatgatgctcatcatgggggctggacaaccaaaatggattggattttccat
acgataaagcagcacgctttgaactga

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