KEGG   Sarcophilus harrisii (Tasmanian devil): 100934049Help
Entry
100934049         CDS       T02286                                 

Gene name
PLCB4
Definition
phospholipase C, beta 4
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:shr00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100934049 (PLCB4)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100934049 (PLCB4)
   04310 Wnt signaling pathway
    100934049 (PLCB4)
   04020 Calcium signaling pathway
    100934049 (PLCB4)
   04070 Phosphatidylinositol signaling system
    100934049 (PLCB4)
   04022 cGMP - PKG signaling pathway
    100934049 (PLCB4)
 Cellular Processes
  Cell communication
   04540 Gap junction
    100934049 (PLCB4)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100934049 (PLCB4)
   04062 Chemokine signaling pathway
    100934049 (PLCB4)
  Endocrine system
   04911 Insulin secretion
    100934049 (PLCB4)
   04912 GnRH signaling pathway
    100934049 (PLCB4)
   04915 Estrogen signaling pathway
    100934049 (PLCB4)
   04921 Oxytocin signaling pathway
    100934049 (PLCB4)
   04918 Thyroid hormone synthesis
    100934049 (PLCB4)
   04919 Thyroid hormone signaling pathway
    100934049 (PLCB4)
   04916 Melanogenesis
    100934049 (PLCB4)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100934049 (PLCB4)
   04270 Vascular smooth muscle contraction
    100934049 (PLCB4)
  Digestive system
   04970 Salivary secretion
    100934049 (PLCB4)
   04971 Gastric acid secretion
    100934049 (PLCB4)
   04972 Pancreatic secretion
    100934049 (PLCB4)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100934049 (PLCB4)
  Nervous system
   04724 Glutamatergic synapse
    100934049 (PLCB4)
   04725 Cholinergic synapse
    100934049 (PLCB4)
   04728 Dopaminergic synapse
    100934049 (PLCB4)
   04726 Serotonergic synapse
    100934049 (PLCB4)
   04720 Long-term potentiation
    100934049 (PLCB4)
   04730 Long-term depression
    100934049 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    100934049 (PLCB4)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100934049 (PLCB4)
  Environmental adaptation
   04713 Circadian entrainment
    100934049 (PLCB4)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100934049 (PLCB4)
   05016 Huntington's disease
    100934049 (PLCB4)
  Infectious diseases
   05146 Amoebiasis
    100934049 (PLCB4)
   05142 Chagas disease (American trypanosomiasis)
    100934049 (PLCB4)
   05143 African trypanosomiasis
    100934049 (PLCB4)
Enzymes [BR:shr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100934049 (PLCB4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
1
AA seq 1132 aa AA seqDB search
MAKPYEFNWQKPVSPFLQEGAIFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRFGSVPKDPKILAALEAFGKSESDLEGRIVCVCSGTDLVNISFTYMVAENPE
IAKQWVEGLRAIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFRKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDTKRAMQIIETYEPDDELKTKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQILLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVNILEDDNEEEIECVDQEEEAHPEFKFGSELSDDFSQKEAVANSVKKAAED
LEHENNKKLHSYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQ
GKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYV
EVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLI
GQRILPLDGLQAGYRHISLRNEGNKPLSLPTVFCNIVLKTYVPDGFGDIVDALSDPKKFL
SVMEKRADQMRAMGIETSDIADVPNDTSKNDKKGKANNAKANVTPQSSSELRPATTSGLG
AGVEGKKGIELIPQVRIEDLKQMKAYLKHLKKQQKEINSLKKKHAKEHSTMQKLHCTQVD
KIVAQFDKEKLSHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTK
EWSEMINTHSAEEQEIRDLHLSQQCDLLKKLLINAHEQQTQQLKLSHDRECKEMRANQAK
ISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLE
HLEVLEKQNEQLLKSCHAVSQTQGKGDAADGEIGSRDGPKTSNSGVKLHNPN
NT seq 3399 nt NT seq  +upstreamnt  +downstreamnt
atggccaaaccatatgaatttaactggcagaagccggtttccccatttttacaggaggga
gccatttttgacagatatgaagaggaatcctttgtatttgaacctaactgcctcttcaaa
gtggatgaatttggtttctttttgacctggaaaagtgaaggaaaggaaggacaggtatta
gagtgctccctcatcaacagcattcgttttggatctgtaccaaaggatcccaaaatccta
gcagctcttgaggcttttggaaaatcagagagtgatttggagggaaggatagtctgtgtc
tgcagtggcactgacctggtgaatatcagcttcacttatatggtggcagaaaatccagaa
attgccaagcaatgggtagaagggttaagagccatcatacataattttagagctaacaac
gttagtccaatgacatgcctgaagaaacactggatgaaattggcatttatgacaaacaca
aatggtaaaattccagttaggagtattactagaacgtttgcatcaggtaaaacagaaaag
gtgatttttcaagcccttaaggagttaggccttcccagcggaaagaatgatgaaattgag
cctgcagcatttacttatgaaaagttttatgaactaacacaaaaaatttgtcctcgaact
gacattgaggacctctttaggaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagaccctcgactgaatgaaattttattc
ccattctatgatacaaaaagggcaatgcagataattgagacttatgagcctgatgatgag
ttgaagacaaaaggactcatatccagtgatgggttttgcagatatctgatgtctgatgaa
aatgcgccagtcttccttgaccgcctggaactttaccaagaaatggatcatcctttggcc
cactactttatcagttcttcccataacacatatctcacaggacgtcaatttggcgggaaa
tcttcggtggaaatgtacagacaaatcctcttagctggatgcagatgtgttgagctagat
tgctgggatgggaaaggtgaagatcaagaaccaataataactcatggaaaagcaatgtgt
acagatattctttttaaggatgtgattcaagccatcaaggaaacagcttttgtcacatca
gaatatcctgtcattctgtcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaagtattgtgaagatctatttggagatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggaagacctttaccgtcccctaatgaccttaaaagaaaaattctgata
aaaaacaaacgactgaaacctgaggtggaaaaaaaacagcttgaagcattaaaaagtatg
atggaagctggagaatcagcagccccagtaaatatcttagaagatgacaatgaagaagaa
atagaatgtgttgaccaagaggaggaagctcacccagaattcaaatttggaagtgaactc
tctgatgatttcagtcaaaaggaagctgttgcaaatagtgtaaagaaggctgcagaagac
cttgaacatgaaaacaataaaaagttgcacagttataataaacgacaaatgagtcggatt
taccccaagggaggtcgagtggattccagtaattacatgcctcagattttctggaatgct
ggctgccagatggtgtcactgaactatcaaaccccagatttagcgatgcaattgaatcag
ggaaaatttgaatataatggatcatgtgggtatcttctcaaaccagatttcatgagacgg
ccagatcgaacatttgatcctttctctgaaacacctgtagatggtgttattgcagctact
tgttcagtgcaggttatatcaggacagttcttatctgataagaaaattggtacgtatgta
gaagtggatatgtacggtttgcccacagacactatacggaaggagtttcgaacgcgtatg
gttatgaacaatggtctcaatcctgtttacaatgaagaatcattcgtattccgaaaggtt
attctccctgatctggctgtcttgagaatagctgtgtatgatgacaacaacaagctgatt
ggtcaaagaatcctccctcttgatggcctccaggcaggctacagacacatttctcttcga
aatgaagggaataaaccattatcactgccaactgttttctgcaacattgtgcttaaaaca
tatgtgccggatggttttggagacattgtggacgctttgtcagacccaaaaaaatttctt
tctgtaatggaaaagagagcagatcaaatgagagcaatgggtattgaaactagtgatata
gctgatgtgccaaatgacacttccaagaatgacaagaaaggaaaagccaataatgctaaa
gccaatgtgactcctcagagcagctctgaactcagaccagctaccacctccggcttggga
gcaggagtggaagggaaaaaaggtattgaacttattcctcaagtgaggatagaagactta
aaacaaatgaaggcttatttaaaacacttaaagaaacaacaaaaagagataaattcttta
aagaagaaacatgcaaaggaacacagcaccatgcagaagttacactgtacacaagttgac
aaaattgtggctcagtttgacaaggagaaattatctcatgagaaaatcttagaaaaagca
atgaagaagaagggaggaagtaattgtcttgaaatgaagaaagaaactgaaattaaaatt
cagacattaacatcagatcataaatctaaggtaaaagagattgtagcccagcatacgaaa
gaatggtcagaaatgatcaatacccacagcgctgaggagcaagaaattcgggatttacac
ctcagccagcagtgtgatctcttgaaaaaactgttgatcaatgctcatgagcaacaaact
cagcagctaaagctttcccatgacagagaatgcaaggaaatgcgcgccaatcaggccaag
atttccatggaaaacagcaaagccatcagccaagacaaatcaatcaaaaataaagcagaa
agagagaggagagtcagggaactaaacagcagtaacactaaaaagtttctggaagaaaga
aagagacttgcaatgaaacagtcaaaagaaatggatcagttgaaaaaagttcaacttgaa
catctagaagtcctggaaaaacaaaatgagcagcttttgaaatcctgtcatgcagtgtct
caaacacaaggcaaaggagatgcagcagatggtgaaattggaagcagagatggaccgaag
accagcaacagtggtgtaaaactccataatccaaactga

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