KEGG   Sarcophilus harrisii (Tasmanian devil): 100934049Help
Entry
100934049         CDS       T02286                                 

Gene name
PLCB4
Definition
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
shr00562  Inositol phosphate metabolism
shr01100  Metabolic pathways
shr04015  Rap1 signaling pathway
shr04020  Calcium signaling pathway
shr04022  cGMP-PKG signaling pathway
shr04062  Chemokine signaling pathway
shr04070  Phosphatidylinositol signaling system
shr04071  Sphingolipid signaling pathway
shr04072  Phospholipase D signaling pathway
shr04261  Adrenergic signaling in cardiomyocytes
shr04270  Vascular smooth muscle contraction
shr04310  Wnt signaling pathway
shr04371  Apelin signaling pathway
shr04540  Gap junction
shr04611  Platelet activation
shr04621  NOD-like receptor signaling pathway
shr04713  Circadian entrainment
shr04720  Long-term potentiation
shr04723  Retrograde endocannabinoid signaling
shr04724  Glutamatergic synapse
shr04725  Cholinergic synapse
shr04726  Serotonergic synapse
shr04728  Dopaminergic synapse
shr04730  Long-term depression
shr04750  Inflammatory mediator regulation of TRP channels
shr04911  Insulin secretion
shr04912  GnRH signaling pathway
shr04915  Estrogen signaling pathway
shr04916  Melanogenesis
shr04918  Thyroid hormone synthesis
shr04919  Thyroid hormone signaling pathway
shr04921  Oxytocin signaling pathway
shr04922  Glucagon signaling pathway
shr04924  Renin secretion
shr04925  Aldosterone synthesis and secretion
shr04926  Relaxin signaling pathway
shr04927  Cortisol synthesis and secretion
shr04928  Parathyroid hormone synthesis, secretion and action
shr04933  AGE-RAGE signaling pathway in diabetic complications
shr04934  Cushing's syndrome
shr04961  Endocrine and other factor-regulated calcium reabsorption
shr04970  Salivary secretion
shr04971  Gastric acid secretion
shr04972  Pancreatic secretion
shr05010  Alzheimer's disease
shr05016  Huntington's disease
shr05142  Chagas disease (American trypanosomiasis)
shr05143  African trypanosomiasis
shr05146  Amoebiasis
shr05200  Pathways in cancer
Module
shr_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:shr00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100934049 (PLCB4)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100934049 (PLCB4)
   04310 Wnt signaling pathway
    100934049 (PLCB4)
   04371 Apelin signaling pathway
    100934049 (PLCB4)
   04020 Calcium signaling pathway
    100934049 (PLCB4)
   04070 Phosphatidylinositol signaling system
    100934049 (PLCB4)
   04072 Phospholipase D signaling pathway
    100934049 (PLCB4)
   04071 Sphingolipid signaling pathway
    100934049 (PLCB4)
   04022 cGMP - PKG signaling pathway
    100934049 (PLCB4)
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    100934049 (PLCB4)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100934049 (PLCB4)
   04621 NOD-like receptor signaling pathway
    100934049 (PLCB4)
   04062 Chemokine signaling pathway
    100934049 (PLCB4)
  Endocrine system
   04911 Insulin secretion
    100934049 (PLCB4)
   04922 Glucagon signaling pathway
    100934049 (PLCB4)
   04912 GnRH signaling pathway
    100934049 (PLCB4)
   04915 Estrogen signaling pathway
    100934049 (PLCB4)
   04921 Oxytocin signaling pathway
    100934049 (PLCB4)
   04926 Relaxin signaling pathway
    100934049 (PLCB4)
   04918 Thyroid hormone synthesis
    100934049 (PLCB4)
   04919 Thyroid hormone signaling pathway
    100934049 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    100934049 (PLCB4)
   04916 Melanogenesis
    100934049 (PLCB4)
   04924 Renin secretion
    100934049 (PLCB4)
   04925 Aldosterone synthesis and secretion
    100934049 (PLCB4)
   04927 Cortisol synthesis and secretion
    100934049 (PLCB4)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100934049 (PLCB4)
   04270 Vascular smooth muscle contraction
    100934049 (PLCB4)
  Digestive system
   04970 Salivary secretion
    100934049 (PLCB4)
   04971 Gastric acid secretion
    100934049 (PLCB4)
   04972 Pancreatic secretion
    100934049 (PLCB4)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100934049 (PLCB4)
  Nervous system
   04724 Glutamatergic synapse
    100934049 (PLCB4)
   04725 Cholinergic synapse
    100934049 (PLCB4)
   04728 Dopaminergic synapse
    100934049 (PLCB4)
   04726 Serotonergic synapse
    100934049 (PLCB4)
   04720 Long-term potentiation
    100934049 (PLCB4)
   04730 Long-term depression
    100934049 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    100934049 (PLCB4)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100934049 (PLCB4)
  Environmental adaptation
   04713 Circadian entrainment
    100934049 (PLCB4)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100934049 (PLCB4)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100934049 (PLCB4)
   05016 Huntington's disease
    100934049 (PLCB4)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    100934049 (PLCB4)
   04934 Cushing's syndrome
    100934049 (PLCB4)
  Infectious diseases
   05146 Amoebiasis
    100934049 (PLCB4)
   05142 Chagas disease (American trypanosomiasis)
    100934049 (PLCB4)
   05143 African trypanosomiasis
    100934049 (PLCB4)
Enzymes [BR:shr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100934049 (PLCB4)
Membrane trafficking [BR:shr04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100934049 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100934049 (PLCB4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI-PLC-X PI-PLC-Y DUF1154 EF-hand_like C2
Motif
Other DBs
NCBI-GeneID: 100934049
NCBI-ProteinID: XP_023350650
Ensembl: ENSSHAG00000012910
Position
1
AA seq 1151 aa AA seqDB search
MSCEIGLVRTHGIQVLKIIMAKPYEFNWQKPVSPFLQEGAIFDRYEEESFVFEPNCLFKV
DEFGFFLTWKSEGKEGQVLECSLINSIRFGSVPKDPKILAALEAFGKSESDLEGRIVCVC
SGTDLVNISFTYMVAENPEIAKQWVEGLRAIIHNFRANNVSPMTCLKKHWMKLAFMTNTN
GKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTD
IEDLFRKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDTKRAMQIIETYEPDDEL
KTKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKS
SVEMYRQILLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSE
YPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIK
NKRLKPEVEKKQLEALKSMMEAGESAAPVNILEDDNEEEIECVDQEEEAHPEFKFGSELS
DDFSQKEAVANSVKKAAEDLEHENNKKLHSYNKRQMSRIYPKGGRVDSSNYMPQIFWNAG
CQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATC
SVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVI
LPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTVFCNIVLKTY
VPDGFGDIVDALSDPKKFLSVMEKRADQMRAMGIETSDIADVPNDTSKNDKKGKANNAKA
NVTPQSSSELRPATTSGLGAGVEGKKGIELIPQVRIEDLKQMKAYLKHLKKQQKEINSLK
KKHAKEHSTMQKLHCTQVDKIVAQFDKEKLSHEKILEKAMKKKGGSNCLEMKKETEIKIQ
TLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCDLLKKLLINAHEQQTQ
QLKLSHDRECKEMRANQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERK
RLAMKQSKEMDQLKKVQLEHLEVLEKQNEQLLKSCHAVSQTQGKGDAADGEIGSRDGPKT
SNSGVKLHNPN
NT seq 3456 nt NT seq  +upstreamnt  +downstreamnt
atgtcctgtgaaataggtttggtaaggacgcatggaatccaggttttgaagataattatg
gccaaaccatatgaatttaactggcagaagccggtttccccatttttacaggagggagcc
atttttgacagatatgaagaggaatcctttgtatttgaacctaactgcctcttcaaagtg
gatgaatttggtttctttttgacctggaaaagtgaaggaaaggaaggacaggtattagag
tgctccctcatcaacagcattcgttttggatctgtaccaaaggatcccaaaatcctagca
gctcttgaggcttttggaaaatcagagagtgatttggagggaaggatagtctgtgtctgc
agtggcactgacctggtgaatatcagcttcacttatatggtggcagaaaatccagaaatt
gccaagcaatgggtagaagggttaagagccatcatacataattttagagctaacaacgtt
agtccaatgacatgcctgaagaaacactggatgaaattggcatttatgacaaacacaaat
ggtaaaattccagttaggagtattactagaacgtttgcatcaggtaaaacagaaaaggtg
atttttcaagcccttaaggagttaggccttcccagcggaaagaatgatgaaattgagcct
gcagcatttacttatgaaaagttttatgaactaacacaaaaaatttgtcctcgaactgac
attgaggacctctttaggaaaatcaatggagacaaaactgattatttaacggtagaccaa
ttagtgagctttctaaatgaacatcaacgagaccctcgactgaatgaaattttattccca
ttctatgatacaaaaagggcaatgcagataattgagacttatgagcctgatgatgagttg
aagacaaaaggactcatatccagtgatgggttttgcagatatctgatgtctgatgaaaat
gcgccagtcttccttgaccgcctggaactttaccaagaaatggatcatcctttggcccac
tactttatcagttcttcccataacacatatctcacaggacgtcaatttggcgggaaatct
tcggtggaaatgtacagacaaatcctcttagctggatgcagatgtgttgagctagattgc
tgggatgggaaaggtgaagatcaagaaccaataataactcatggaaaagcaatgtgtaca
gatattctttttaaggatgtgattcaagccatcaaggaaacagcttttgtcacatcagaa
tatcctgtcattctgtcctttgaaaatcactgcagcaaatatcaacagtacaagatgtcc
aagtattgtgaagatctatttggagatctcctgttgaaacaagcacttgaatcacatcca
cttgaaccaggaagacctttaccgtcccctaatgaccttaaaagaaaaattctgataaaa
aacaaacgactgaaacctgaggtggaaaaaaaacagcttgaagcattaaaaagtatgatg
gaagctggagaatcagcagccccagtaaatatcttagaagatgacaatgaagaagaaata
gaatgtgttgaccaagaggaggaagctcacccagaattcaaatttggaagtgaactctct
gatgatttcagtcaaaaggaagctgttgcaaatagtgtaaagaaggctgcagaagacctt
gaacatgaaaacaataaaaagttgcacagttataataaacgacaaatgagtcggatttac
cccaagggaggtcgagtggattccagtaattacatgcctcagattttctggaatgctggc
tgccagatggtgtcactgaactatcaaaccccagatttagcgatgcaattgaatcaggga
aaatttgaatataatggatcatgtgggtatcttctcaaaccagatttcatgagacggcca
gatcgaacatttgatcctttctctgaaacacctgtagatggtgttattgcagctacttgt
tcagtgcaggttatatcaggacagttcttatctgataagaaaattggtacgtatgtagaa
gtggatatgtacggtttgcccacagacactatacggaaggagtttcgaacgcgtatggtt
atgaacaatggtctcaatcctgtttacaatgaagaatcattcgtattccgaaaggttatt
ctccctgatctggctgtcttgagaatagctgtgtatgatgacaacaacaagctgattggt
caaagaatcctccctcttgatggcctccaggcaggctacagacacatttctcttcgaaat
gaagggaataaaccattatcactgccaactgttttctgcaacattgtgcttaaaacatat
gtgccggatggttttggagacattgtggacgctttgtcagacccaaaaaaatttctttct
gtaatggaaaagagagcagatcaaatgagagcaatgggtattgaaactagtgatatagct
gatgtgccaaatgacacttccaagaatgacaagaaaggaaaagccaataatgctaaagcc
aatgtgactcctcagagcagctctgaactcagaccagctaccacctccggcttgggagca
ggagtggaagggaaaaaaggtattgaacttattcctcaagtgaggatagaagacttaaaa
caaatgaaggcttatttaaaacacttaaagaaacaacaaaaagagataaattctttaaag
aagaaacatgcaaaggaacacagcaccatgcagaagttacactgtacacaagttgacaaa
attgtggctcagtttgacaaggagaaattatctcatgagaaaatcttagaaaaagcaatg
aagaagaagggaggaagtaattgtcttgaaatgaagaaagaaactgaaattaaaattcag
acattaacatcagatcataaatctaaggtaaaagagattgtagcccagcatacgaaagaa
tggtcagaaatgatcaatacccacagcgctgaggagcaagaaattcgggatttacacctc
agccagcagtgtgatctcttgaaaaaactgttgatcaatgctcatgagcaacaaactcag
cagctaaagctttcccatgacagagaatgcaaggaaatgcgcgccaatcaggccaagatt
tccatggaaaacagcaaagccatcagccaagacaaatcaatcaaaaataaagcagaaaga
gagaggagagtcagggaactaaacagcagtaacactaaaaagtttctggaagaaagaaag
agacttgcaatgaaacagtcaaaagaaatggatcagttgaaaaaagttcaacttgaacat
ctagaagtcctggaaaaacaaaatgagcagcttttgaaatcctgtcatgcagtgtctcaa
acacaaggcaaaggagatgcagcagatggtgaaattggaagcagagatggaccgaagacc
agcaacagtggtgtaaaactccataatccaaactga

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