KEGG   Sarcophilus harrisii (Tasmanian devil): 100934311Help
Entry
100934311         CDS       T02286                                 

Gene name
PLCB1
Definition
phospholipase C, beta 1 (phosphoinositide-specific)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:shr00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100934311 (PLCB1)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100934311 (PLCB1)
   04310 Wnt signaling pathway
    100934311 (PLCB1)
   04020 Calcium signaling pathway
    100934311 (PLCB1)
   04070 Phosphatidylinositol signaling system
    100934311 (PLCB1)
   04022 cGMP - PKG signaling pathway
    100934311 (PLCB1)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    100934311 (PLCB1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100934311 (PLCB1)
   04062 Chemokine signaling pathway
    100934311 (PLCB1)
  Endocrine system
   04911 Insulin secretion
    100934311 (PLCB1)
   04912 GnRH signaling pathway
    100934311 (PLCB1)
   04915 Estrogen signaling pathway
    100934311 (PLCB1)
   04921 Oxytocin signaling pathway
    100934311 (PLCB1)
   04918 Thyroid hormone synthesis
    100934311 (PLCB1)
   04919 Thyroid hormone signaling pathway
    100934311 (PLCB1)
   04916 Melanogenesis
    100934311 (PLCB1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100934311 (PLCB1)
   04270 Vascular smooth muscle contraction
    100934311 (PLCB1)
  Digestive system
   04970 Salivary secretion
    100934311 (PLCB1)
   04971 Gastric acid secretion
    100934311 (PLCB1)
   04972 Pancreatic secretion
    100934311 (PLCB1)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100934311 (PLCB1)
  Nervous system
   04724 Glutamatergic synapse
    100934311 (PLCB1)
   04725 Cholinergic synapse
    100934311 (PLCB1)
   04728 Dopaminergic synapse
    100934311 (PLCB1)
   04726 Serotonergic synapse
    100934311 (PLCB1)
   04720 Long-term potentiation
    100934311 (PLCB1)
   04730 Long-term depression
    100934311 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    100934311 (PLCB1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100934311 (PLCB1)
  Environmental adaptation
   04713 Circadian entrainment
    100934311 (PLCB1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100934311 (PLCB1)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100934311 (PLCB1)
   05016 Huntington's disease
    100934311 (PLCB1)
  Infectious diseases
   05146 Amoebiasis
    100934311 (PLCB1)
   05142 Chagas disease (American trypanosomiasis)
    100934311 (PLCB1)
   05143 African trypanosomiasis
    100934311 (PLCB1)
Enzymes [BR:shr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100934311 (PLCB1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
1
AA seq 1109 aa AA seqDB search
MGHICLFYVGCDRTFGFIYEWTDEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRI
PLKNIYRMFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIF
SEFGAKSRPYLTVDQMMEFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQ
ISVDGFMRYLSGEENGVVPPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMY
RQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPYPILL
SFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKK
SHKSSEGSAKKKLSEQASNTYSDSSSVFEPSSPGAGEADMESDDDDDDDDDCKKSSMDEG
TAGSEAMATEEMSNLVNYIQPVKFESFETSKKRNKSFEMSSFVETKGLEQLTKSPVEFVE
YNKMQLSRIYPKGTRVDSSNYMPQVFWNAGCQMVALNFQTVDLAMQLNLGMYEYNGKSGY
RLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEIDMFGLPVDT
RRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIR
PGYHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLA
ALTLEDEEEVKKEADLGETPTESKSEPRPAPAENGVNHTTSLTPKPPSQVVHNQPAPGSV
KAPAKTEDLIQSVLTDVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEH
TTKYNEIQNDYLRRRTVLEKNAKKDSKKKSEPSSPDHGSSTMEQDLAALDAEMTQKLVEL
KDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKEL
KKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEDAQSKRQEKLLEKH
KEIRQQILDEKPKMQVELDQEYQDKFKRLPLEILEFVQEAMKGKISEEGNHSSASSSLTS
DSSKVNHKSPPNEEELEEDNAEKVFDTSL
NT seq 3330 nt NT seq  +upstreamnt  +downstreamnt
atggggcatatatgtctgttttatgttggatgtgacaggacctttggttttatctatgaa
tggacagatgaggttttcagtttggcaactaacctgctggcacaaaacatgtctagagac
gcatttctggaaaaagcctataccaaactcaagctacaggtcactcctgaaggacgaatt
cctctcaaaaacatctatcgcatgttttcagcagaccgaaaacgagttgaaactgcttta
gaagcttgtagtcttccatcttcaaggaatgattcaatacctcaagaagacttcactcca
gaagtatatagagttttcttaaacaacctttgccctcgacctgaaattgataacatcttt
tctgaatttggtgccaagagtagaccatatcttactgttgatcaaatgatggagtttatc
aatttaaagcaacgagatccccgactgaatgaaatcctttatccaccattaaaacaggaa
caagtccaagtgctaattgagaaatatgaaccaaacaactccttagcaaaaaaaggacag
atctcagtagatggattcatgcgctatctgagtggagaagaaaatggagttgttccacct
gagaaactggatttgaatgaagatatgtctcagccactctcccattatttcattaattct
tcacataacacctacctcacagctggccagctagctggcaactcctcagtagagatgtat
cgccaagtcctcttgtctggctgtcgctgtgtggagctggactgctggaagggaagaaca
gctgaagaggagcctgtaattacccatggtttcactatgacaacagaaatctcttttaag
gaggtgatagaagctattgccgagtgtgcatttaagacatcaccatacccaatcctcctt
tcttttgaaaatcatgtggattctcctaaacagcaagccaagatggcagaatactgcaga
ctaatatttggagatgcactgcttatggagccattagaaaaatatccacttgaatctgga
gttcctcttccaagccctatggacttaatgtataaaattttggtaaaaaacaaaaagaaa
tcacacaagtcttcagaaggaagtgccaaaaagaagttatcagagcaggcatccaatact
tacagtgattcatccagtgtgtttgaaccttcatctcctggagcaggagaagcagacatg
gagagtgatgatgatgatgacgatgatgatgactgtaaaaagtcttcaatggatgagggc
actgctggtagtgaagccatggccacagaagaaatgtctaacctggtaaactatatacag
ccagtgaaatttgagtcatttgagacatcaaagaaaagaaacaaaagttttgaaatgtct
tcttttgtggaaaccaaaggacttgagcaactaacaaagtctccagtagaatttgtagaa
tataacaaaatgcagcttagcaggatttatccaaagggaacacgtgtggattcttcaaat
tacatgccccaagttttctggaatgctggttgtcaaatggtagctcttaacttccaaaca
gtagacttggctatgcaattgaacttggggatgtatgaatacaatgggaaaagtggttac
agactaaagccagaatttatgagacgaccagacaagcattttgatccatttactgaaggt
atcgtggatggtatagtagccaatactttatctgttaagatcatttcaggtcagtttctt
tctgataaaaaagttgggacttacgtagaaatagatatgtttggcttacctgtggacacc
aggagaaaagcctttaagaccaagacatctcaaggaaatgctgtaaatccagtctgggaa
gaagaacctatagtgttcaagaaggtggtcctaccttctctggcctgtttaaggatagca
gcatatgaagaaggaggtaaatttattggtcaccggatattgcctgtacaagcaattcga
ccaggctatcactacatttgtctgaggaatgaaaggaatcaacctttgatgcttccagca
gtctttgtatacatagaggtgaaagactatgtgccagatacatatgcagatgtaattgaa
gcattgtcaaatcctattcgatatgtgaacctgatggagcaaagagctaagcagctagca
gcactaactctagaagatgaagaagaagtaaagaaagaggctgatcttggggaaacacca
acagaatctaagagtgaacccagaccagcaccagcagagaatggagtcaatcacactaca
tcactgacaccaaaaccaccatctcaagttgtccacaatcaaccagccccaggttcagtt
aaagcacctgcaaaaactgaagatcttattcagagtgtcttaacagatgtggaagcccag
acaattgaggaactaaagcagcagaagtcttttgttaaacttcagaagaaacattacaaa
gaaatgaaggacctcgtgaaaagacaccacaagaaaaccactgacctcatcaaagagcac
accacaaagtacaatgagatccaaaatgattacttacgaaggaggactgtcctagaaaaa
aacgccaaaaaggacagtaaaaagaaatctgaacccagcagccctgatcatggttcttca
acaatggagcaggaccttgctgccctggatgcagaaatgacacagaaattggtagaatta
aaggacaagcaacagcagcagctattgaatctgcggcaggaacagtattacagtgaaaaa
taccagaaacgagaacatatcaaattgcttattcagaaattgacagatgttgcagaagaa
tgccagaacaatcagttaaagaaactgaaagaaatctgtgagaaagaaaagaaagaattg
aagaagaaaatggataaaaaaagacaggagaagataacagaagcaaaatcgaaagacaag
agccaaatggaagaggagaagactgaaatgatccggtcatacatccaagaagtggtgcag
tacataaagagactagaagatgcccaaagcaaaaggcaagagaaacttttagagaaacac
aaggagatccgtcaacagatactggatgaaaaaccaaagatgcaggtggaacttgaccag
gaatatcaagacaaattcaaaaggctccccctggaaattctggagtttgtacaggaagcc
atgaaaggaaagatcagtgaagaaggcaatcacagttcagcctcttcttccctcacctca
gatagcagcaaagtgaaccacaagtctcccccaaatgaggaagaactagaagaagacaat
gcagaaaaagtgtttgatacatccctttaa

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