KEGG   Sarcophilus harrisii (Tasmanian devil): 100934311Help
Entry
100934311         CDS       T02286                                 

Gene name
PLCB1
Definition
(RefSeq) phospholipase C, beta 1 (phosphoinositide-specific)
  KO
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Renin secretion
Aldosterone synthesis and secretion
AGE-RAGE signaling pathway in diabetic complications
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:shr00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100934311 (PLCB1)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100934311 (PLCB1)
   04310 Wnt signaling pathway
    100934311 (PLCB1)
   04020 Calcium signaling pathway
    100934311 (PLCB1)
   04070 Phosphatidylinositol signaling system
    100934311 (PLCB1)
   04072 Phospholipase D signaling pathway
    100934311 (PLCB1)
   04071 Sphingolipid signaling pathway
    100934311 (PLCB1)
   04022 cGMP - PKG signaling pathway
    100934311 (PLCB1)
 Cellular Processes
  Cellular community
   04540 Gap junction
    100934311 (PLCB1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100934311 (PLCB1)
   04062 Chemokine signaling pathway
    100934311 (PLCB1)
  Endocrine system
   04911 Insulin secretion
    100934311 (PLCB1)
   04922 Glucagon signaling pathway
    100934311 (PLCB1)
   04912 GnRH signaling pathway
    100934311 (PLCB1)
   04915 Estrogen signaling pathway
    100934311 (PLCB1)
   04921 Oxytocin signaling pathway
    100934311 (PLCB1)
   04918 Thyroid hormone synthesis
    100934311 (PLCB1)
   04919 Thyroid hormone signaling pathway
    100934311 (PLCB1)
   04916 Melanogenesis
    100934311 (PLCB1)
   04924 Renin secretion
    100934311 (PLCB1)
   04925 Aldosterone synthesis and secretion
    100934311 (PLCB1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100934311 (PLCB1)
   04270 Vascular smooth muscle contraction
    100934311 (PLCB1)
  Digestive system
   04970 Salivary secretion
    100934311 (PLCB1)
   04971 Gastric acid secretion
    100934311 (PLCB1)
   04972 Pancreatic secretion
    100934311 (PLCB1)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100934311 (PLCB1)
  Nervous system
   04724 Glutamatergic synapse
    100934311 (PLCB1)
   04725 Cholinergic synapse
    100934311 (PLCB1)
   04728 Dopaminergic synapse
    100934311 (PLCB1)
   04726 Serotonergic synapse
    100934311 (PLCB1)
   04720 Long-term potentiation
    100934311 (PLCB1)
   04730 Long-term depression
    100934311 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    100934311 (PLCB1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100934311 (PLCB1)
  Environmental adaptation
   04713 Circadian entrainment
    100934311 (PLCB1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100934311 (PLCB1)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100934311 (PLCB1)
   05016 Huntington's disease
    100934311 (PLCB1)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    100934311 (PLCB1)
  Infectious diseases
   05146 Amoebiasis
    100934311 (PLCB1)
   05142 Chagas disease (American trypanosomiasis)
    100934311 (PLCB1)
   05143 African trypanosomiasis
    100934311 (PLCB1)
Enzymes [BR:shr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100934311 (PLCB1)
Membrane trafficking [BR:shr04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100934311 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100934311 (PLCB1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Ensembl: 
Position
1
AA seq 1217 aa AA seqDB search
MAGAQPGVHALQLKPVSVSDNLKKGIKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPHVKECLDLNMHTLWQRMAFVVXKQKVVNIQYLNTIA
VPEELGKEWTDEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRMFSAD
RKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSRPYLT
VDQMMEFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLSG
EENGVVPPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVE
LDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPYPILLSFENHVDSPKQQ
AKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSAKKK
LSEQASNTYSDSSSVFEPSSPGAGEADMESDDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFETSKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQVFWNAGCQMVALNFQTVDLAMQLNLGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEIDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADLGETPTESKSEPRPAPAENGVNHTTSLTPKPPSQVVHNQPAPGSVKAPAKTEDLIQS
VLTDVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRTVLEKNAKKDSKKKSEPSSPDHGSSTMEQDLAALDAEMTQKLVELKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEDAQSKRQEKLLEKHKEIRQQILDEKP
KMQVELDQEYQDKFKRLPLEILEFVQEAMKGKISEEGNHSSASSSLTSDSSKVNHKSPPN
EEELEEDNAEKVFDTSL
NT seq 3654 nt NT seq  +upstreamnt  +downstreamnt
atggccggggcacagccaggagttcacgctttgcaactcaaacctgtcagtgtctccgac
aacctgaagaaaggcatcaaatttgtcaaatgggatgatgactccactattgttactcca
attattctgaggactgatccacaaggatttttcttttattggacagatcaaaataaggag
actgaactcttagatcttagccttgtcaaggatgccagatgtgggaaacatgccaaagcc
ccaaaggacccacatgttaaagaatgtttggatttaaatatgcacacattgtggcagaga
atggcctttgtagtctgaaaacaaaaggttgttaatattcaatatttaaatacaattgca
gtgccagaagaattaggcaaggaatggacagatgaggttttcagtttggcaactaacctg
ctggcacaaaacatgtctagagacgcatttctggaaaaagcctataccaaactcaagcta
caggtcactcctgaaggacgaattcctctcaaaaacatctatcgcatgttttcagcagac
cgaaaacgagttgaaactgctttagaagcttgtagtcttccatcttcaaggaatgattca
atacctcaagaagacttcactccagaagtatatagagttttcttaaacaacctttgccct
cgacctgaaattgataacatcttttctgaatttggtgccaagagtagaccatatcttact
gttgatcaaatgatggagtttatcaatttaaagcaacgagatccccgactgaatgaaatc
ctttatccaccattaaaacaggaacaagtccaagtgctaattgagaaatatgaaccaaac
aactccttagcaaaaaaaggacagatctcagtagatggattcatgcgctatctgagtgga
gaagaaaatggagttgttccacctgagaaactggatttgaatgaagatatgtctcagcca
ctctcccattatttcattaattcttcacataacacctacctcacagctggccagctagct
ggcaactcctcagtagagatgtatcgccaagtcctcttgtctggctgtcgctgtgtggag
ctggactgctggaagggaagaacagctgaagaggagcctgtaattacccatggtttcact
atgacaacagaaatctcttttaaggaggtgatagaagctattgccgagtgtgcatttaag
acatcaccatacccaatcctcctttcttttgaaaatcatgtggattctcctaaacagcaa
gccaagatggcagaatactgcagactaatatttggagatgcactgcttatggagccatta
gaaaaatatccacttgaatctggagttcctcttccaagccctatggacttaatgtataaa
attttggtaaaaaacaaaaagaaatcacacaagtcttcagaaggaagtgccaaaaagaag
ttatcagagcaggcatccaatacttacagtgattcatccagtgtgtttgaaccttcatct
cctggagcaggagaagcagacatggagagtgatgatgatgatgacgatgatgatgactgt
aaaaagtcttcaatggatgagggcactgctggtagtgaagccatggccacagaagaaatg
tctaacctggtaaactatatacagccagtgaaatttgagtcatttgagacatcaaagaaa
agaaacaaaagttttgaaatgtcttcttttgtggaaaccaaaggacttgagcaactaaca
aagtctccagtagaatttgtagaatataacaaaatgcagcttagcaggatttatccaaag
ggaacacgtgtggattcttcaaattacatgccccaagttttctggaatgctggttgtcaa
atggtagctcttaacttccaaacagtagacttggctatgcaattgaacttggggatgtat
gaatacaatgggaaaagtggttacagactaaagccagaatttatgagacgaccagacaag
cattttgatccatttactgaaggtatcgtggatggtatagtagccaatactttatctgtt
aagatcatttcaggtcagtttctttctgataaaaaagttgggacttacgtagaaatagat
atgtttggcttacctgtggacaccaggagaaaagcctttaagaccaagacatctcaagga
aatgctgtaaatccagtctgggaagaagaacctatagtgttcaagaaggtggtcctacct
tctctggcctgtttaaggatagcagcatatgaagaaggaggtaaatttattggtcaccgg
atattgcctgtacaagcaattcgaccaggctatcactacatttgtctgaggaatgaaagg
aatcaacctttgatgcttccagcagtctttgtatacatagaggtgaaagactatgtgcca
gatacatatgcagatgtaattgaagcattgtcaaatcctattcgatatgtgaacctgatg
gagcaaagagctaagcagctagcagcactaactctagaagatgaagaagaagtaaagaaa
gaggctgatcttggggaaacaccaacagaatctaagagtgaacccagaccagcaccagca
gagaatggagtcaatcacactacatcactgacaccaaaaccaccatctcaagttgtccac
aatcaaccagccccaggttcagttaaagcacctgcaaaaactgaagatcttattcagagt
gtcttaacagatgtggaagcccagacaattgaggaactaaagcagcagaagtcttttgtt
aaacttcagaagaaacattacaaagaaatgaaggacctcgtgaaaagacaccacaagaaa
accactgacctcatcaaagagcacaccacaaagtacaatgagatccaaaatgattactta
cgaaggaggactgtcctagaaaaaaacgccaaaaaggacagtaaaaagaaatctgaaccc
agcagccctgatcatggttcttcaacaatggagcaggaccttgctgccctggatgcagaa
atgacacagaaattggtagaattaaaggacaagcaacagcagcagctattgaatctgcgg
caggaacagtattacagtgaaaaataccagaaacgagaacatatcaaattgcttattcag
aaattgacagatgttgcagaagaatgccagaacaatcagttaaagaaactgaaagaaatc
tgtgagaaagaaaagaaagaattgaagaagaaaatggataaaaaaagacaggagaagata
acagaagcaaaatcgaaagacaagagccaaatggaagaggagaagactgaaatgatccgg
tcatacatccaagaagtggtgcagtacataaagagactagaagatgcccaaagcaaaagg
caagagaaacttttagagaaacacaaggagatccgtcaacagatactggatgaaaaacca
aagatgcaggtggaacttgaccaggaatatcaagacaaattcaaaaggctccccctggaa
attctggagtttgtacaggaagccatgaaaggaaagatcagtgaagaaggcaatcacagt
tcagcctcttcttccctcacctcagatagcagcaaagtgaaccacaagtctcccccaaat
gaggaagaactagaagaagacaatgcagaaaaagtgtttgatacatccctttaa

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