ID ACKA_STRAW Reviewed; 405 AA.
AC Q82JD1;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 01-MAY-2013, entry version 68.
DE RecName: Full=Acetate kinase;
DE EC=2.7.2.1;
DE AltName: Full=Acetokinase;
GN Name=ackA; OrderedLocusNames=SAV_2824;
OS Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 /
OS NCIMB 12804 / NRRL 8165 / MA-4680).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Streptomycineae; Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=227882;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 /
RC MA-4680;
RX PubMed=11572948; DOI=10.1073/pnas.211433198;
RA Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C.,
RA Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T.,
RA Kikuchi H., Shiba T., Sakaki Y., Hattori M.;
RT "Genome sequence of an industrial microorganism Streptomyces
RT avermitilis: deducing the ability of producing secondary
RT metabolites.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 /
RC MA-4680;
RX PubMed=12692562; DOI=10.1038/nbt820;
RA Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M., Omura S.;
RT "Complete genome sequence and comparative analysis of the industrial
RT microorganism Streptomyces avermitilis.";
RL Nat. Biotechnol. 21:526-531(2003).
CC -!- FUNCTION: Catalyzes the formation of acetyl phosphate from acetate
CC and ATP. Can also catalyze the reverse reaction (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + acetate = ADP + acetyl phosphate.
CC -!- COFACTOR: Mg(2+). Can also accept Mn(2+) (By similarity).
CC -!- PATHWAY: Metabolic intermediate biosynthesis; acetyl-CoA
CC biosynthesis; acetyl-CoA from acetate: step 1/2.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the acetokinase family.
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DR EMBL; BA000030; BAC70535.1; -; Genomic_DNA.
DR RefSeq; NP_824000.1; NC_003155.4.
DR ProteinModelPortal; Q82JD1; -.
DR STRING; 227882.SAV_2824; -.
DR EnsemblBacteria; BAC70535; BAC70535; SAV_2824.
DR GeneID; 1210559; -.
DR KEGG; sma:SAV_2824; -.
DR PATRIC; 23719229; VBIStrAve112782_3024.
DR eggNOG; COG0282; -.
DR HOGENOM; HOG000288399; -.
DR KO; K00925; -.
DR OMA; HESVLID; -.
DR ProtClustDB; PRK00180; -.
DR BioCyc; SAVE227882:GJU1-2845-MONOMER; -.
DR UniPathway; UPA00340; UER00458.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008776; F:acetate kinase activity; IEA:HAMAP.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006085; P:acetyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006082; P:organic acid metabolic process; IEA:InterPro.
DR HAMAP; MF_00020; Acetate_kinase; 1; -.
DR InterPro; IPR004372; Ac/Proprionate_kinase.
DR InterPro; IPR000890; Aliphatic_acid_kin_short-chain.
DR InterPro; IPR023865; Aliphatic_acid_kinase_CS.
DR PANTHER; PTHR21060; PTHR21060; 1.
DR Pfam; PF00871; Acetate_kinase; 1.
DR PIRSF; PIRSF000722; Acetate_prop_kin; 1.
DR PRINTS; PR00471; ACETATEKNASE.
DR TIGRFAMs; TIGR00016; ackA; 1.
DR PROSITE; PS01075; ACETATE_KINASE_1; 1.
DR PROSITE; PS01076; ACETATE_KINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium;
KW Metal-binding; Nucleotide-binding; Transferase.
FT CHAIN 1 405 Acetate kinase.
FT /FTId=PRO_0000107620.
FT NP_BIND 210 214 ATP (By similarity).
FT NP_BIND 284 286 ATP (By similarity).
FT NP_BIND 332 336 ATP (By similarity).
FT ACT_SITE 150 150 Proton donor/acceptor (By similarity).
FT METAL 10 10 Magnesium (By similarity).
FT METAL 386 386 Magnesium (By similarity).
FT BINDING 17 17 ATP (By similarity).
FT BINDING 93 93 Substrate (By similarity).
FT SITE 182 182 Transition state stabilizer (By
FT similarity).
FT SITE 243 243 Transition state stabilizer (By
FT similarity).
SQ SEQUENCE 405 AA; 43242 MW; E832A7531B3750EA CRC64;
MSPTRVLVLN SGSSSVKYQL LDMRDSSRLA VGLVERIGEG TSRLKHTPLT TGVSRELTSP
VADHAAALKT VAEELAKDGL GLDSPELAAI GHRVVHGGRS FTEPTVIDDD VLAEIERLIP
VAPLHNPANL TGIRTAMALR PDLPQVAVFD TAFHTTMPES AARYAIDVKT ADEHRVRRYG
FHGTSHAYVS RATAKLLGRA PKDVNLIVLH LGNGASASAV RGGRCVDTSM GLTPLEGLVM
GTRSGDMDPA VIFHLMRVGG MSTDEVDTLL NTKSGLIGLC GDNDMREIRR RVDEGDEQAA
LAFDIYIHRL KKYIGAYYAV LGRVDAVAFT AGVGENAAPV RAAAIAGLEE LGLVVDSERN
AVRSDEPRIV SPEDARVAVA VVPTDEELEI AQQTYALVGT AHHLT
//
