ID ARGC_YERPE Reviewed; 334 AA.
AC Q8ZA86; Q0WA88;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 01-MAY-2013, entry version 95.
DE RecName: Full=N-acetyl-gamma-glutamyl-phosphate reductase;
DE Short=AGPR;
DE EC=1.2.1.38;
DE AltName: Full=N-acetyl-glutamate semialdehyde dehydrogenase;
DE Short=NAGSA dehydrogenase;
GN Name=argC; OrderedLocusNames=YPO3927, y0310, YP_3123;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G.,
RA Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V.,
RA Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M.,
RA Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/JB.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C.,
RA Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V.,
RA Straley S.C., McDonough K.A., Nilles M.L., Matson J.S., Blattner F.R.,
RA Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z.,
RA Jin L., Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J.,
RA Yang H., Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- CATALYTIC ACTIVITY: N-acetyl-L-glutamate 5-semialdehyde + NADP(+)
CC + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-
CC acetyl-L-ornithine from L-glutamate: step 3/4.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the NAGSA dehydrogenase family. Type 1
CC subfamily.
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DR EMBL; AL590842; CAL22510.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM83901.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS63293.1; -; Genomic_DNA.
DR PIR; AC0478; AC0478.
DR RefSeq; NP_667650.1; NC_004088.1.
DR RefSeq; NP_994416.1; NC_005810.1.
DR RefSeq; YP_002348800.1; NC_003143.1.
DR ProteinModelPortal; Q8ZA86; -.
DR SMR; Q8ZA86; 1-334.
DR STRING; 214092.YPO3927; -.
DR DNASU; 1145257; -.
DR EnsemblBacteria; AAM83901; AAM83901; y0310.
DR EnsemblBacteria; AAS63293; AAS63293; YP_3123.
DR GeneID; 1145257; -.
DR GeneID; 1176768; -.
DR GeneID; 2763912; -.
DR KEGG; ype:YPO3927; -.
DR KEGG; ypk:y0310; -.
DR KEGG; ypm:YP_3123; -.
DR eggNOG; COG0002; -.
DR HOGENOM; HOG000254902; -.
DR KO; K00145; -.
DR OMA; VCRIAVH; -.
DR ProtClustDB; PRK00436; -.
DR UniPathway; UPA00068; UER00108.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003942; F:N-acetyl-gamma-glutamyl-phosphate reductase activity; IEA:HAMAP.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0006526; P:arginine biosynthetic process; IEA:HAMAP.
DR Gene3D; 3.40.50.720; -; 1.
DR HAMAP; MF_00150; ArgC_type1; 1; -.
DR InterPro; IPR023013; AGPR_AS.
DR InterPro; IPR000706; AGPR_type-1.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR InterPro; IPR012280; Semialdhyde_DH_dimer_dom.
DR Pfam; PF01118; Semialdhyde_dh; 1.
DR Pfam; PF02774; Semialdhyde_dhC; 1.
DR SMART; SM00859; Semialdhyde_dh; 1.
DR TIGRFAMs; TIGR01850; argC; 1.
DR PROSITE; PS01224; ARGC; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome;
KW Cytoplasm; NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1 334 N-acetyl-gamma-glutamyl-phosphate
FT reductase.
FT /FTId=PRO_0000112480.
FT ACT_SITE 154 154 By similarity.
SQ SEQUENCE 334 AA; 35870 MW; 00AC62A772F45CCF CRC64;
MLNTLIVGAS GYAGAELTAY LNRHPHMNIT GLAVSAQSAD AGKLLSDLHP QLKGILDLPL
QPLVDVAQAA KGIDVVFLAT AHEVSHDLAP QFLAAGCVVF DLSGAFRVRD AAFYSQYYGF
EHQHPDWLDK AVYGLAEWQS EDIKQAQLIA VPGCYPTASQ LALKPLVDGQ LLNDAQWPVI
NAVSGVSGAG RKASMGNSFC EVSLQPYGLF THRHQPEIVT HLGTPVIFTP HLGNFARGIL
ATITCRLKAG VTAQNIADAY HHAYQNKPLV RLYQQGVPAL KAVVGLPFCD IGFSVQGEHL
IIVATEDNLL KGAAAQAVQC MNIRFGFPET QSLL
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