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Database: UniProt/SWISS-PROT
Entry: ARLY_METM5
LinkDB: ARLY_METM5
Original site: ARLY_METM5 
ID   ARLY_METM5              Reviewed;         481 AA.
AC   A4G0I4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   29-OCT-2014, entry version 51.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE            Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN   Name=argH {ECO:0000255|HAMAP-Rule:MF_00006};
GN   OrderedLocusNames=MmarC5_1671;
OS   Methanococcus maripaludis (strain C5 / ATCC BAA-1333).
OC   Archaea; Euryarchaeota; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=402880;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C5 / ATCC BAA-1333;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D.,
RA   Han C., Detter J.C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Whitman W.B.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Methanococcus maripaludis C5.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 2-(N(omega)-L-arginino)succinate = fumarate +
CC       L-arginine. {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-
CC       arginine from L-ornithine and carbamoyl phosphate: step 3/3.
CC       {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR   EMBL; CP000609; ABO35968.1; -; Genomic_DNA.
DR   RefSeq; YP_001098182.1; NC_009135.1.
DR   ProteinModelPortal; A4G0I4; -.
DR   STRING; 402880.MmarC5_1671; -.
DR   EnsemblBacteria; ABO35968; ABO35968; MmarC5_1671.
DR   GeneID; 4928440; -.
DR   KEGG; mmq:MmarC5_1671; -.
DR   eggNOG; COG0165; -.
DR   HOGENOM; HOG000242744; -.
DR   KO; K01755; -.
DR   OMA; EMANEYS; -.
DR   BioCyc; MMAR402880:GJ2R-1706-MONOMER; -.
DR   UniPathway; UPA00068; UER00114.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR11444; PTHR11444; 1.
DR   PANTHER; PTHR11444:SF3; PTHR11444:SF3; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00838; argH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome;
KW   Cytoplasm; Lyase.
FT   CHAIN         1    481       Argininosuccinate lyase.
FT                                /FTId=PRO_1000000500.
SQ   SEQUENCE   481 AA;  54135 MW;  9161FDAF6F154C3D CRC64;
     MNILRRGRLG SNVKEDVMKF TTSLEFDKEI FESDILCDIA HTTMLVEQNV ISEENGKKII
     AELKKIAEKG METLDLDPSL DDIHMVIESE LIKELGEDVA GRMHTGRSRN DEVATDLRLS
     LRKKVLEIIT HLITMEKNML AVSNEHKETL TVGYTHLQQA QPVTFGHQIL SHISAIERDI
     SRFFDTYNRI NLSPLGCGAM ATTGFNLNRK RTQELLGFYG LIENSMDGVS SRDFIVETMA
     NISMLGTNLS KICEELVVFS SAEFNTIEIA NEYTSTSSIM PQKKNPDVAE ITRAKLSTLN
     GELVTVLTIM KALPNTYNRD LQEISPHLWK SVYTLIDSIQ MVDGMISTVK VNKERMKENA
     EKNYSTATEL ADTLVRECGI AFRMAHGIVG ELVKRSIEEK VEIKEIISEV LEKNNLSLSQ
     EKIDTALDPF ENVKLRNVIG GPAPEEVERA ISSFNEKISA YKENLDEKIA EIESVKENLL
     K
//
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