ID   AROA_METTH              Reviewed;         419 AA.
AC   O26860;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   29-MAY-2013, entry version 96.
DE   RecName: Full=Probable 3-phosphoshikimate 1-carboxyvinyltransferase;
DE            EC=2.5.1.19;
DE   AltName: Full=5-enolpyruvylshikimate-3-phosphate synthase;
DE            Short=EPSP synthase;
DE            Short=EPSPS;
GN   Name=aroA; OrderedLocusNames=MTH_766;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 /
OS   JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium
OS   thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K.,
RA   Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D.,
RA   Spadafora R., Vicare R., Wang Y., Wierzbowski J., Gibson R.,
RA   Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S.,
RA   McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M.,
RA   Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum
RT   deltaH: functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- CATALYTIC ACTIVITY: Phosphoenolpyruvate + 3-phosphoshikimate =
CC       phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 6/7.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the EPSP synthase family.
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DR   EMBL; AE000666; AAB85269.1; -; Genomic_DNA.
DR   PIR; D69202; D69202.
DR   RefSeq; NP_275908.1; NC_000916.1.
DR   ProteinModelPortal; O26860; -.
DR   STRING; 187420.MTH766; -.
DR   EnsemblBacteria; AAB85269; AAB85269; MTH_766.
DR   GeneID; 1471174; -.
DR   KEGG; mth:MTH766; -.
DR   eggNOG; COG0128; -.
DR   KO; K00800; -.
DR   OMA; SNAGPFL; -.
DR   ProtClustDB; PRK02427; -.
DR   BioCyc; MTHE187420:GJNM-768-MONOMER; -.
DR   UniPathway; UPA00053; UER00089.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003866; F:3-phosphoshikimate 1-carboxyvinyltransferase activity; IEA:EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.65.10.10; -; 2.
DR   HAMAP; MF_00210; EPSP_synth; 1; -.
DR   InterPro; IPR001986; Enolpyruvate_Tfrase_dom.
DR   InterPro; IPR006264; EPSP_synthase.
DR   InterPro; IPR023193; EPSP_synthase_CS.
DR   InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR   Pfam; PF00275; EPSP_synthase; 1.
DR   PIRSF; PIRSF000505; EPSPS; 1.
DR   SUPFAM; SSF55205; RNA3'_cycl/enolpyr_transf_A/B; 1.
DR   TIGRFAMs; TIGR01356; aroA; 1.
DR   PROSITE; PS00104; EPSP_SYNTHASE_1; 1.
DR   PROSITE; PS00885; EPSP_SYNTHASE_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Cytoplasm; Reference proteome; Transferase.
FT   CHAIN         1    419       Probable 3-phosphoshikimate 1-
FT                                carboxyvinyltransferase.
FT                                /FTId=PRO_0000088332.
SQ   SEQUENCE   419 AA;  44748 MW;  395BDDB8C5262AC9 CRC64;
     MDLTVEKSGN LEGTVKAPPS KSYTHRAVII AALAEGVSEI RDPLIAEDTL SSLNACRAFG
     IRVDEGDAWT VHGSGGELET PDDVIYLGNS GTTLRLMTSV AGLAENYTVL TGDESLRTRP
     MQPLLDALRP LGVEALSSRM NGLPPIIVRG GLRGGSTSIR GDVSSQFISS ILIAAPLTEG
     VEVMVEGDFI SRPYVDMTVD VMERFSVPVD YSEGTFRVEP AVYRGLDYTV EGDYSSASYL
     AGAVAAAGGD VLIENLFRDS RQGDRIILDI ISDMGAEVRR GEDHVRIAST GELSGVSVNL
     HDAPDLLPTV AVLGALATGR TEIGGVEHAR YKETDRISTC AAELRRLGVD VTELPDGMII
     EGGASGGTVW SHGDHRLAMA FTLIGLREGI TIRDAEVFSV SFPDFPERMM QIGCRMNLS
//