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Database: UniProt/SWISS-PROT
Entry: CAPP_MYCLE
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ID   CAPP_MYCLE              Reviewed;         934 AA.
AC   P46710; Q9CCN5;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 2.
DT   28-FEB-2018, entry version 108.
DE   RecName: Full=Phosphoenolpyruvate carboxylase;
DE            Short=PEPC;
DE            Short=PEPCase;
DE            EC=4.1.1.31;
GN   Name=ppc; OrderedLocusNames=ML0578; ORFNames=B1496_C3_207;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid
CC       source for the tricarboxylic acid cycle. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: Phosphate + oxaloacetate = H(2)O +
CC       phosphoenolpyruvate + HCO(3)(-).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the PEPCase type 1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA17132.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; U00013; AAA17132.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL583919; CAC30086.1; -; Genomic_DNA.
DR   PIR; B86981; B86981.
DR   PIR; S72765; S72765.
DR   RefSeq; NP_301490.1; NC_002677.1.
DR   RefSeq; WP_010907814.1; NC_002677.1.
DR   ProteinModelPortal; P46710; -.
DR   SMR; P46710; -.
DR   STRING; 272631.ML0578; -.
DR   EnsemblBacteria; CAC30086; CAC30086; CAC30086.
DR   GeneID; 909360; -.
DR   KEGG; mle:ML0578; -.
DR   PATRIC; fig|272631.5.peg.1007; -.
DR   Leproma; ML0578; -.
DR   eggNOG; ENOG4105CCA; Bacteria.
DR   eggNOG; COG2352; LUCA.
DR   HOGENOM; HOG000238647; -.
DR   KO; K01595; -.
DR   OMA; PWVFGWT; -.
DR   OrthoDB; POG091H040O; -.
DR   BioCyc; MLEP272631:G1GT5-633-MONOMER; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   HAMAP; MF_00595; PEPcase_type1; 1.
DR   InterPro; IPR021135; PEP_COase.
DR   InterPro; IPR022805; PEP_COase_bac/pln-type.
DR   InterPro; IPR018129; PEP_COase_Lys_AS.
DR   InterPro; IPR033129; PEPCASE_His_AS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   PANTHER; PTHR30523; PTHR30523; 1.
DR   Pfam; PF00311; PEPcase; 1.
DR   PRINTS; PR00150; PEPCARBXLASE.
DR   SUPFAM; SSF51621; SSF51621; 1.
DR   PROSITE; PS00781; PEPCASE_1; 1.
DR   PROSITE; PS00393; PEPCASE_2; 1.
PE   3: Inferred from homology;
KW   Carbon dioxide fixation; Complete proteome; Lyase; Magnesium;
KW   Reference proteome.
FT   CHAIN         1    934       Phosphoenolpyruvate carboxylase.
FT                                /FTId=PRO_0000166600.
FT   ACT_SITE    161    161       {ECO:0000250}.
FT   ACT_SITE    593    593       {ECO:0000250}.
SQ   SEQUENCE   934 AA;  102516 MW;  3EE8FD762EC45180 CRC64;
     MVEFSDAILE PIGAVQRTRV GREATEPMRA DIRLLGTILG DTLREQNGDE VFDLVERVRV
     ESFRVRRSEI DRADMARMFS GLDIHLAIPI IRAFSHFALL ANVAEDIHRE RRRHIHLDAG
     EPLRDSSLAA TYAKLDLAKL DSATVADALT GAVVSPVITA HPTETRRRTV FVTQRRITEL
     MRLHAEGHTE TADGRSIERE LRRQILTLWQ TALIRLARLQ ISDEIDVGLR YYSAALFHVI
     PQVNSEVRNA LRARWPDAEL LSGPILQPGS WIGGDRDGNP NVTADVVRRA TGSAAYTVVA
     HYLAELTHLE QELSMSARLI TVTPELATLA ASCQDAACAD EPYRRALRVI RGRLSSTAAH
     ILDQQPPNQL GLGLPPYSTP AELCADLDTI EASLCTHGAA LLADDRLALL REGVGVFGFH
     LCGLDMRQNS DVHEEVVAEL LAWAGMHQDY SSLPEDQRVK LLVAELGNRR PLVGDRAQLS
     DLARGELAVL AAAAHAVELY GSAAVPNYII SMCQSVSDVL EVAILLKETG LLDASGSQPY
     CPVGISPLFE TIDDLHNGAA ILHAMLELPL YRTLVAARGN WQEVMLGYSD SNKDGGYLAA
     NWAVYRAELA LVDVARKTGI RLRLFHGRGG TVGRGGGPSY QAILAQPPGA VNGSLRLTEQ
     GEVIAAKYAE PQIARRNLES LVAATLESTL LDVEGLGDAA ESAYAILDEV AGLARRSYAE
     LVNTPGFVDY FQASTPVSEI GSLNIGNRPT SRKPTTSIAD LRAIPWVLAW SQSRVMLPGW
     YGTGSAFQQW VAAGPESESQ RVEMLHDLYQ RWPFFRSVLS NMAQVLAKSD LGLAARYAEL
     VVDEALRRRV FDKIADEHRR TIAIHKLITG HDDLLADNPA LARSVFNRFP YLEPLNHLQV
     ELLRRYRSGH DDEMVQRGIL LTMNGLASAL RNSG
//
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