ID CH60_STAAN Reviewed; 538 AA.
AC P99083; Q99SL7;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 01-MAY-2013, entry version 61.
DE RecName: Full=60 kDa chaperonin;
DE AltName: Full=GroEL protein;
DE AltName: Full=Protein Cpn60;
GN Name=groL; Synonyms=groEL; OrderedLocusNames=SA1836;
OS Staphylococcus aureus (strain N315).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX NCBI_TaxID=158879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N315;
RX PubMed=11418146; DOI=10.1016/S0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I.,
RA Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K.,
RA Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M.,
RA Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M.,
RA Ogasawara N., Hayashi H., Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus
RT aureus.";
RL Lancet 357:1225-1240(2001).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=N315;
RX PubMed=15590099; DOI=10.1016/j.mimet.2004.09.017;
RA Scherl A., Francois P., Bento M., Deshusses J.M., Charbonnier Y.,
RA Converset V., Huyghe A., Walter N., Hoogland C., Appel R.D.,
RA Sanchez J.-C., Zimmermann-Ivol C.G., Corthals G.L., Hochstrasser D.F.,
RA Schrenzel J.;
RT "Correlation of proteomic and transcriptomic profiles of
RT Staphylococcus aureus during the post-exponential phase of growth.";
RL J. Microbiol. Methods 60:247-257(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=N315;
RA Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.;
RT "Shotgun proteomic analysis of total and membrane protein extracts of
RT S. aureus strain N315.";
RL Submitted (OCT-2007) to UniProtKB.
CC -!- FUNCTION: Prevents misfolding and promotes the refolding and
CC proper assembly of unfolded polypeptides generated under stress
CC conditions (By similarity).
CC -!- SUBUNIT: Oligomer of 14 subunits composed of two stacked rings of
CC 7 subunits (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the chaperonin (HSP60) family.
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DR EMBL; BA000018; BAB43116.1; -; Genomic_DNA.
DR PIR; C89994; C89994.
DR RefSeq; NP_375137.1; NC_002745.2.
DR ProteinModelPortal; P99083; -.
DR SMR; P99083; 3-524.
DR STRING; 158879.SA1836; -.
DR SWISS-2DPAGE; P99083; -.
DR PRIDE; P99083; -.
DR EnsemblBacteria; BAB43116; BAB43116; BAB43116.
DR GeneID; 1124728; -.
DR KEGG; sau:SA1836; -.
DR PATRIC; 19576110; VBIStaAur116463_1987.
DR eggNOG; COG0459; -.
DR HOGENOM; HOG000076290; -.
DR KO; K04077; -.
DR OMA; YNGVITV; -.
DR ProtClustDB; PRK00013; -.
DR BioCyc; SAUR158879:GJCB-1960-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0042026; P:protein refolding; IEA:HAMAP.
DR HAMAP; MF_00600; CH60; 1; -.
DR InterPro; IPR018370; Chaperonin_Cpn60_CS.
DR InterPro; IPR001844; Chaprnin_Cpn60.
DR InterPro; IPR002423; Cpn60/TCP-1.
DR PANTHER; PTHR11353; PTHR11353; 1.
DR Pfam; PF00118; Cpn60_TCP1; 1.
DR PRINTS; PR00298; CHAPERONIN60.
DR SUPFAM; SSF48592; GroEL-ATPase; 1.
DR TIGRFAMs; TIGR02348; GroEL; 1.
DR PROSITE; PS00296; CHAPERONINS_CPN60; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Chaperone; Complete proteome; Cytoplasm;
KW Nucleotide-binding.
FT CHAIN 1 538 60 kDa chaperonin.
FT /FTId=PRO_0000063533.
SQ SEQUENCE 538 AA; 57572 MW; A3D8595603DC9313 CRC64;
MVKQLKFSED ARQAMLRGVD QLANAVKVTI GPKGRNVVLD KEFTAPLITN DGVTIAKEIE
LEDPYENMGA KLVQEVANKT NEIAGDGTTT ATVLAQAMIQ EGLKNVTSGA NPVGLRQGID
KAVKVAVEAL HENSQKVENK NEIAQVGAIS AADEEIGRYI SEAMEKVGND GVITIEESNG
LNTELEVVEG MQFDRGYQSP YMVTDSDKMV AELERPYILV TDKKISSFQD ILPLLEQVVQ
SNRPILIVAD EVEGDALTNI VLNRMRGTFT AVAVKAPGFG DRRKAMLEDL AILTGAQVIT
DDLGLDLKDA SIDMLGTASK VEVTKDNTTV VDGDGDENSI DARVSQLKSQ IEETESDFDR
EKLQERLAKL AGGVAVIKVG AASETELKER KLRIEDALNS TRAAVEEGIV AGGGTALVNV
YQKVSEIEAE GDIETGVNIV LKALTAPVRQ IAENAGLEGS VIVERLKNAE PGVGFNAATN
EWVNMLEAGI VDPTKVTRSA LQHAASVAAM FLTTEAVVAS IPEKNNDQPN MGGMPGMM
//
