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Database: UniProt/SWISS-PROT
Entry: DNLI_ANADE
LinkDB: DNLI_ANADE
Original site: DNLI_ANADE 
ID   DNLI_ANADE              Reviewed;         513 AA.
AC   Q2IH69;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-OCT-2017, entry version 88.
DE   RecName: Full=Probable DNA ligase {ECO:0000255|HAMAP-Rule:MF_00407};
DE            EC=6.5.1.1 {ECO:0000255|HAMAP-Rule:MF_00407};
DE   AltName: Full=Polydeoxyribonucleotide synthase [ATP] {ECO:0000255|HAMAP-Rule:MF_00407};
GN   Name=lig {ECO:0000255|HAMAP-Rule:MF_00407};
GN   OrderedLocusNames=Adeh_4160;
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA ligase that seals nicks in double-stranded DNA
CC       during DNA replication, DNA recombination and DNA repair.
CC       {ECO:0000255|HAMAP-Rule:MF_00407}.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000255|HAMAP-Rule:MF_00407}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00407};
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00407}.
DR   EMBL; CP000251; ABC83924.1; -; Genomic_DNA.
DR   RefSeq; WP_011423206.1; NC_007760.1.
DR   ProteinModelPortal; Q2IH69; -.
DR   SMR; Q2IH69; -.
DR   STRING; 290397.Adeh_4160; -.
DR   PRIDE; Q2IH69; -.
DR   EnsemblBacteria; ABC83924; ABC83924; Adeh_4160.
DR   KEGG; ade:Adeh_4160; -.
DR   eggNOG; ENOG4107QIM; Bacteria.
DR   eggNOG; COG1793; LUCA.
DR   HOGENOM; HOG000036008; -.
DR   KO; K10747; -.
DR   OMA; WLFEESY; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3260.10; -; 2.
DR   HAMAP; MF_00407; DNA_ligase; 1.
DR   InterPro; IPR022865; DNA_ligae_ATP-dep_bac/arc.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage;
KW   DNA recombination; DNA repair; DNA replication; Ligase; Magnesium;
KW   Metal-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    513       Probable DNA ligase.
FT                                /FTId=PRO_0000365216.
FT   ACT_SITE    215    215       N6-AMP-lysine intermediate.
FT                                {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     213    213       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     220    220       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     235    235       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     264    264       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     304    304       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     376    376       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     382    382       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
SQ   SEQUENCE   513 AA;  54363 MW;  96017811B13D10FB CRC64;
     MLLAELAEVS RAVAATPARL EKIARLADAL GRLAPDERAV GASWLAGDLP GGRVGIGAAT
     LRAALEAAPP ERSGPGLTVA EVDAALRRIA AVAGPGSGAA RRRELDALLA RAGNPERRFL
     AALVLGELRQ GALEGVLADA VAKAAGLPAA EVRRAAMLAG ALPPVAEAAL SEGAAGLARF
     RLRVGEPVSP MLAQTAADVD EALRALGGEA ALEWKLDGAR IQAHRDGEAV RVFSRSLRDV
     TAAVPEVVAL LRAAPEPRLV LDGEAIALRA DGTPEPFQVT MRRFGRKLDV ERLAPELPLT
     AFFFDALVAG GAELLARPER ERWAALARAI PAERRVPRLV TRDPAEARAF LEDALARGQE
     GVVAKALDAP YEAGRRGAAW LKVKRAHTLD LVVLAAEWGS GRRRGWLSNL HLGARDPASG
     GFVMLGKTFK GMTDAMLAWQ TDRLKALATG PLDAWQVPVR PELVVEVAFD GIQSSPRYPG
     GLALRFARVK RYREDKRPED ADTIETVRGL YGG
//
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