ID ECX2_ARCFU Reviewed; 259 AA.
AC O29756;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 01-MAY-2013, entry version 73.
DE RecName: Full=Probable exosome complex exonuclease 2;
DE EC=3.1.13.-;
GN OrderedLocusNames=AF_0494;
OS Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM
OS 9628 / NBRC 100126).
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales;
OC Archaeoglobaceae; Archaeoglobus.
OX NCBI_TaxID=224325;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126;
RX PubMed=9389475; DOI=10.1038/37052;
RA Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E.,
RA Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D.,
RA Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C.,
RA Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G., Gill S.R.,
RA Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J.,
RA Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A.,
RA Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A.,
RA Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P.,
RA Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C.,
RA Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O.,
RA Woese C.R., Venter J.C.;
RT "The complete genome sequence of the hyperthermophilic, sulphate-
RT reducing archaeon Archaeoglobus fulgidus.";
RL Nature 390:364-370(1997).
CC -!- FUNCTION: Probably involved in the 3'->5' degradation of a variety
CC of RNA species (Potential).
CC -!- SUBUNIT: Component of the archaeal exosome multienzyme
CC ribonuclease complex (Potential).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC -!- SIMILARITY: Belongs to the RNase PH family.
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DR EMBL; AE000782; AAB90743.1; -; Genomic_DNA.
DR PIR; F69311; F69311.
DR RefSeq; NP_069330.1; NC_000917.1.
DR PDB; 2BA0; X-ray; 2.70 A; G/H/I=1-259.
DR PDB; 2BA1; X-ray; 2.70 A; G/H/I=1-259.
DR PDB; 3M7N; X-ray; 2.40 A; G/H/I=1-259.
DR PDB; 3M85; X-ray; 3.00 A; G/H/I=1-259.
DR PDBsum; 2BA0; -.
DR PDBsum; 2BA1; -.
DR PDBsum; 3M7N; -.
DR PDBsum; 3M85; -.
DR ProteinModelPortal; O29756; -.
DR SMR; O29756; 3-258.
DR STRING; 224325.AF0494; -.
DR EnsemblBacteria; AAB90743; AAB90743; AF_0494.
DR GeneID; 1483711; -.
DR KEGG; afu:AF0494; -.
DR eggNOG; COG2123; -.
DR KO; K12589; -.
DR OMA; QAASQFI; -.
DR ProtClustDB; PRK04282; -.
DR BioCyc; AFUL224325:GJBC-507-MONOMER; -.
DR EvolutionaryTrace; O29756; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:HAMAP.
DR GO; GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
DR GO; GO:0006401; P:RNA catabolic process; IEA:HAMAP.
DR HAMAP; MF_00622; Exosome_Exonucl_2; 1; -.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR015847; ExoRNase_PH_dom2.
DR InterPro; IPR020869; Exosome_complex_exonuc_2_prob.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR Pfam; PF01138; RNase_PH; 1.
DR Pfam; PF03725; RNase_PH_C; 1.
DR SUPFAM; SSF55666; 3_ExoRNase; 1.
DR SUPFAM; SSF54211; Ribosomal_S5_D2-typ_fold; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Cytoplasm; Exonuclease; Exosome;
KW Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1 259 Probable exosome complex exonuclease 2.
FT /FTId=PRO_0000139996.
FT HELIX 5 19
FT STRAND 35 39
FT STRAND 45 53
FT STRAND 56 67
FT STRAND 78 84
FT STRAND 91 93
FT STRAND 95 98
FT HELIX 100 115
FT HELIX 121 124
FT STRAND 125 127
FT TURN 128 130
FT STRAND 131 143
FT HELIX 148 161
FT HELIX 168 170
FT STRAND 172 174
FT STRAND 185 192
FT STRAND 195 199
FT HELIX 204 207
FT STRAND 211 216
FT STRAND 222 230
FT HELIX 235 254
SQ SEQUENCE 259 AA; 28647 MW; E8289D46F9DDCCB3 CRC64;
MPEDILVDIK RDYVLSKLRD NERIDGRGFD EFRKVEIIPN VIEKAEGSAL VKLGDTQVVV
GVKMQPGEPY PDTPDRGVII VNAELVPLAS PTFEPGPPDE NSIELARVVD RGIRESEAVD
LSKLVIEEGE KVWIVFVDIH ALDDDGNLLD ASALAAIAAL MNTKVPAERF DLGEDYLLPV
RDLPVSVTSL IVGNKYLVDP SREEMSVGDT TLTITTDKDD NVVAMQKSGG YLLDEKLFDE
LLDVSINCAR KLREKFKEI
//
