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Database: UniProt/SWISS-PROT
Entry: EFTU_THENN
LinkDB: EFTU_THENN
Original site: EFTU_THENN 
ID   EFTU_THENN              Reviewed;         400 AA.
AC   B9K884;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   24-JAN-2024, entry version 80.
DE   RecName: Full=Elongation factor Tu {ECO:0000255|HAMAP-Rule:MF_00118};
DE            Short=EF-Tu {ECO:0000255|HAMAP-Rule:MF_00118};
GN   Name=tuf {ECO:0000255|HAMAP-Rule:MF_00118}; OrderedLocusNames=CTN_0991;
OS   Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E).
OC   Bacteria; Thermotogota; Thermotogae; Thermotogales; Thermotogaceae;
OC   Thermotoga.
OX   NCBI_TaxID=309803;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E;
RA   Lim S.K., Kim J.S., Cha S.H., Park B.C., Lee D.S., Tae H.S., Kim S.-J.,
RA   Kim J.J., Park K.J., Lee S.Y.;
RT   "The genome sequence of the hyperthermophilic bacterium Thermotoga
RT   neapolitana.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-
CC       tRNA to the A-site of ribosomes during protein biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00118}.
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00118}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00118}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00118}.
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DR   EMBL; CP000916; ACM23167.1; -; Genomic_DNA.
DR   RefSeq; WP_015919484.1; NC_011978.1.
DR   PDB; 5W75; X-ray; 2.30 A; A/B/C/D=9-400.
DR   PDBsum; 5W75; -.
DR   AlphaFoldDB; B9K884; -.
DR   SMR; B9K884; -.
DR   STRING; 309803.CTN_0991; -.
DR   KEGG; tna:CTN_0991; -.
DR   eggNOG; COG0050; Bacteria.
DR   HOGENOM; CLU_007265_0_1_0; -.
DR   OMA; EGDKEWG; -.
DR   Proteomes; UP000000445; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule.
DR   CDD; cd01884; EF_Tu; 1.
DR   CDD; cd03697; EFTU_II; 1.
DR   CDD; cd03707; EFTU_III; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 2.
DR   HAMAP; MF_00118_B; EF_Tu_B; 1.
DR   InterPro; IPR041709; EF-Tu_GTP-bd.
DR   InterPro; IPR004161; EFTu-like_2.
DR   InterPro; IPR033720; EFTU_2.
DR   InterPro; IPR031157; G_TR_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR   InterPro; IPR004541; Transl_elong_EFTu/EF1A_bac/org.
DR   InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR   NCBIfam; TIGR00485; EF-Tu; 1.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF03144; GTP_EFTU_D2; 1.
DR   Pfam; PF03143; GTP_EFTU_D3; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50447; Translation proteins; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Elongation factor; GTP-binding;
KW   Nucleotide-binding; Protein biosynthesis.
FT   CHAIN           1..400
FT                   /note="Elongation factor Tu"
FT                   /id="PRO_1000201420"
FT   DOMAIN          10..208
FT                   /note="tr-type G"
FT   REGION          19..26
FT                   /note="G1"
FT                   /evidence="ECO:0000250"
FT   REGION          60..64
FT                   /note="G2"
FT                   /evidence="ECO:0000250"
FT   REGION          81..84
FT                   /note="G3"
FT                   /evidence="ECO:0000250"
FT   REGION          136..139
FT                   /note="G4"
FT                   /evidence="ECO:0000250"
FT   REGION          174..176
FT                   /note="G5"
FT                   /evidence="ECO:0000250"
FT   BINDING         19..26
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00118"
FT   BINDING         81..85
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00118"
FT   BINDING         136..139
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00118"
FT   STRAND          12..20
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   HELIX           25..37
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   TURN            38..40
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   HELIX           47..51
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          55..58
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          61..64
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          66..71
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          76..81
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   HELIX           85..94
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          100..107
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   TURN            108..110
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   HELIX           114..126
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          130..136
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   HELIX           138..140
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   HELIX           144..160
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   TURN            165..167
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          170..172
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   HELIX           175..179
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   HELIX           188..190
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   HELIX           191..203
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   TURN            210..212
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          216..218
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          221..225
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   TURN            226..228
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          229..235
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          238..241
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          246..250
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          257..266
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          279..284
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          297..300
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          306..316
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   HELIX           319..321
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          335..338
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          341..348
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          362..374
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          380..385
FT                   /evidence="ECO:0007829|PDB:5W75"
FT   STRAND          388..398
FT                   /evidence="ECO:0007829|PDB:5W75"
SQ   SEQUENCE   400 AA;  44555 MW;  9CE18CDAB8A86A50 CRC64;
     MAKEKFVRTK PHVNVGTIGH IDHGKSTLTA AITKYLSLKG LAQYVPYDQI DKAPEEKARG
     ITINITHVEY ETEKRHYAHI DCPGHADYIK NMITGAAQMD GAILVVAATD GPMPQTREHV
     LLARQVEVPY MIVFINKTDM VDDPELIELV EMEVRDLLSQ YEYPGDEVPV IKGSALKALE
     APDDPNHEAY KPIQELLDAM DNYIPDPQRD VDKPFLMPIE DVFSITGRGT VVTGRIERGR
     IRPGDEVEII GLSYEIRKTV VTSVEMFRKE LDEGIAGDNV GCLLRGIDKD EVERGQVLAA
     PGSIKPHKRF KAEVYVLKKE EGGRHTPFTK GYKPQFYIRT ADVTGEIVGL PEGVEMVMPG
     DHVEMEIELI YPVAIEKGQR FAIREGGRTV GAGVVTEVIE
//
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