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Database: UniProt/SWISS-PROT
Entry: FEMB_STAEQ
LinkDB: FEMB_STAEQ
Original site: FEMB_STAEQ 
ID   FEMB_STAEQ              Reviewed;         417 AA.
AC   Q5HPG5;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   13-NOV-2013, entry version 60.
DE   RecName: Full=Aminoacyltransferase FemB;
DE            EC=2.3.2.18;
DE   AltName: Full=Factor essential for expression of methicillin resistance B;
DE   AltName: Full=N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase;
GN   Name=femB; OrderedLocusNames=SERP0947;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/JB.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T.,
RA   Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J.,
RA   Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S.,
RA   Haft D.H., Vamathevan J.J., Khouri H., Utterback T.R., Lee C.,
RA   Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H.,
RA   Hance I.R., Nelson K.E., Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete
RT   genome analysis of an early methicillin-resistant Staphylococcus
RT   aureus strain and a biofilm-producing methicillin-resistant
RT   Staphylococcus epidermidis strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Catalyzes the incorporation of amino acid(s) into the
CC       interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA
CC       as amino acid donor (By similarity).
CC   -!- CATALYTIC ACTIVITY: MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-
CC       Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + 2
CC       glycyl-tRNA = MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-
CC       D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + 2
CC       tRNA.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the FemABX family.
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DR   EMBL; CP000029; AAW54350.1; -; Genomic_DNA.
DR   RefSeq; YP_188525.1; NC_002976.3.
DR   ProteinModelPortal; Q5HPG5; -.
DR   STRING; 176279.SERP0947; -.
DR   EnsemblBacteria; AAW54350; AAW54350; SERP0947.
DR   GeneID; 3242013; -.
DR   KEGG; ser:SERP0947; -.
DR   PATRIC; 19612765; VBIStaEpi130894_0925.
DR   eggNOG; COG2348; -.
DR   HOGENOM; HOG000280006; -.
DR   KO; K11695; -.
DR   OMA; WIYQIYD; -.
DR   OrthoDB; EOG6PZX7G; -.
DR   ProtClustDB; CLSK885230; -.
DR   BioCyc; SEPI176279:GJJB-973-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016755; F:transferase activity, transferring amino-acyl groups; IEA:InterPro.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.630.30; -; 3.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR003447; Methicillin-R.
DR   Pfam; PF02388; FemAB; 1.
DR   SUPFAM; SSF55729; SSF55729; 3.
DR   PROSITE; PS51191; FEMABX; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Cell shape; Cell wall biogenesis/degradation;
KW   Complete proteome; Cytoplasm; Peptidoglycan synthesis; Transferase.
FT   CHAIN         1    417       Aminoacyltransferase FemB.
FT                                /FTId=PRO_0000204746.
SQ   SEQUENCE   417 AA;  49345 MW;  27A8BAEF93B2F1C9 CRC64;
     MKFTELTVKE FENFVQNPSL ESHYFQVKEN IATRESDGFQ VVLLGVKDDD NRVIAASLFS
     KIPTMGSYVY YSNRGPVMDY SDLGLVDFYL KELDKYLHQH QCLYVKLDPY WLYQVYDKDI
     NPLTEKNDAL VNLFKSHGYD HHGFTTQYDS SSQVRWMGVL DLEGKTPASL RKEFDSQRKR
     NINKAINYGV KVRFLSKDEF DLFLDLYRET EARTGFASKT DDYFYNFIEH YGDKVLVPLA
     YIDLNEYIQH LQESLNDKEN RRDDMMAKEN KTDKQLKKIA ELDKQIDHDK KELLQASELR
     QTDGEILNLA SGVYFANAYE VNYFSGGSSE KYNQYMGPYA MHWHMINYCF DNGYDRYNFY
     GLSGDFTENS EDYGVYRFKR GFNVRIEELI GDFYKPINKV KYWLFNTLDR IRNKLKK
//
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