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Database: UniProt/SWISS-PROT
Entry: GAL1_SALDC
LinkDB: GAL1_SALDC
Original site: GAL1_SALDC 
ID   GAL1_SALDC              Reviewed;         382 AA.
AC   B5FP41;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   01-OCT-2014, entry version 45.
DE   RecName: Full=Galactokinase {ECO:0000255|HAMAP-Rule:MF_00246};
DE            EC=2.7.1.6 {ECO:0000255|HAMAP-Rule:MF_00246};
DE   AltName: Full=Galactose kinase {ECO:0000255|HAMAP-Rule:MF_00246};
GN   Name=galK {ECO:0000255|HAMAP-Rule:MF_00246};
GN   OrderedLocusNames=SeD_A0869;
OS   Salmonella dublin (strain CT_02021853).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=439851;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT_02021853;
RX   PubMed=21602358; DOI=10.1128/JB.00297-11;
RA   Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA   Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT   CRISPR-mediated adaptive sublineage evolution.";
RL   J. Bacteriol. 193:3556-3568(2011).
CC   -!- FUNCTION: Catalyzes the transfer of the gamma-phosphate of ATP to
CC       D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
CC       {ECO:0000255|HAMAP-Rule:MF_00246}.
CC   -!- CATALYTIC ACTIVITY: ATP + alpha-D-galactose = ADP + alpha-D-
CC       galactose 1-phosphate. {ECO:0000255|HAMAP-Rule:MF_00246}.
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00246}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00246}.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00246}.
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DR   EMBL; CP001144; ACH77684.1; -; Genomic_DNA.
DR   RefSeq; YP_002214739.1; NC_011205.1.
DR   ProteinModelPortal; B5FP41; -.
DR   STRING; 439851.SeD_A0869; -.
DR   EnsemblBacteria; ACH77684; ACH77684; SeD_A0869.
DR   PATRIC; 18489941; VBISalEnt111443_0925.
DR   eggNOG; COG0153; -.
DR   HOGENOM; HOG000241100; -.
DR   OMA; VMPCAIN; -.
DR   OrthoDB; EOG6DG2SH; -.
DR   BioCyc; SENT439851:GH2Z-859-MONOMER; -.
DR   UniPathway; UPA00214; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004335; F:galactokinase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.70.890; -; 1.
DR   HAMAP; MF_00246; Galactokinase; 1.
DR   InterPro; IPR000705; Galactokinase.
DR   InterPro; IPR022963; Galactokinase_bac.
DR   InterPro; IPR019741; Galactokinase_CS.
DR   InterPro; IPR019539; GalKase_gal-bd.
DR   InterPro; IPR013750; GHMP_kinase_C_dom.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR006203; GHMP_knse_ATP-bd_CS.
DR   InterPro; IPR006206; Mevalonate/galactokinase.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   Pfam; PF10509; GalKase_gal_bdg; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF000530; Galactokinase; 1.
DR   PRINTS; PR00473; GALCTOKINASE.
DR   PRINTS; PR00959; MEVGALKINASE.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55060; SSF55060; 1.
DR   TIGRFAMs; TIGR00131; gal_kin; 1.
DR   PROSITE; PS00106; GALACTOKINASE; 1.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Complete proteome; Cytoplasm;
KW   Galactose metabolism; Kinase; Magnesium; Metal-binding;
KW   Nucleotide-binding; Transferase.
FT   CHAIN         1    382       Galactokinase.
FT                                /FTId=PRO_1000100839.
FT   NP_BIND     124    130       ATP. {ECO:0000255|HAMAP-Rule:MF_00246}.
FT   REGION       34     37       Substrate binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_00246}.
FT   ACT_SITE    174    174       Proton acceptor. {ECO:0000255|HAMAP-
FT                                Rule:MF_00246}.
FT   METAL       130    130       Magnesium. {ECO:0000255|HAMAP-
FT                                Rule:MF_00246}.
FT   METAL       162    162       Magnesium. {ECO:0000255|HAMAP-
FT                                Rule:MF_00246}.
FT   BINDING     223    223       Substrate. {ECO:0000255|HAMAP-
FT                                Rule:MF_00246}.
FT   SITE         28     28       Transition state stabilizer.
FT                                {ECO:0000255|HAMAP-Rule:MF_00246}.
SQ   SEQUENCE   382 AA;  41246 MW;  764243641DAC1EBC CRC64;
     MNLKEKTRAL FAEIFGYPAT HTIQAPGRVN LIGEHTDYND GFVLPCAIDY QTVISCAPRD
     DRTVRVIAAD YDNQVDEFSL DAPIVTHDSQ QWSNYVRGVV KHLQQRNNAF GGVDMVISGN
     VPQGAGLSSS ASLEVAVGTV FQQLYHLPLD GAQIALNGQE AENQFVGCNC GIMDQLISAL
     GKKDHALLID CRTLGAKAVS MPKGVAVVII NSNFKRTLVG SEYNTRREQC ETGARFFQQP
     ALRDVSLEAF NAVASELDPV VAKRVRHVLS ENARTVEAAS ALEKGDLQRM GQLMAESHAS
     MRDDFEITVP QIDTLVDIVK ATIGDQGGVR MTGGGFGGCV VALIPEDLVP AVQQAVAQQY
     EAKTGIKETF YVCKPSQGAG QC
//
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