ID GAL1_SALDC Reviewed; 382 AA.
AC B5FP41;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 1.
DT 29-MAY-2013, entry version 37.
DE RecName: Full=Galactokinase;
DE EC=2.7.1.6;
DE AltName: Full=Galactose kinase;
GN Name=galK; OrderedLocusNames=SeD_A0869;
OS Salmonella dublin (strain CT_02021853).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=439851;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT_02021853;
RA Ravel J., Fricke W.F., White D., McDermott P., Mammel M., Rosovitz M.,
RA Leclerc J., Cebula T., Sebastian Y.;
RT "Complete genome of Salmonella dublin strain CT_02021853.";
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the transfer of the gamma-phosphate of ATP to
CC D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: ATP + D-galactose = ADP + alpha-D-galactose 1-
CC phosphate.
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC -!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.
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DR EMBL; CP001144; ACH77684.1; -; Genomic_DNA.
DR RefSeq; YP_002214739.1; NC_011205.1.
DR ProteinModelPortal; B5FP41; -.
DR STRING; 439851.SeD_A0869; -.
DR EnsemblBacteria; ACH77684; ACH77684; SeD_A0869.
DR GeneID; 6872273; -.
DR KEGG; sed:SeD_A0869; -.
DR PATRIC; 18489941; VBISalEnt111443_0925.
DR eggNOG; COG0153; -.
DR HOGENOM; HOG000241100; -.
DR KO; K00849; -.
DR OMA; MPCAINY; -.
DR ProtClustDB; PRK05101; -.
DR BioCyc; SENT439851:GH2Z-859-MONOMER; -.
DR UniPathway; UPA00214; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004335; F:galactokinase activity; IEA:HAMAP.
DR GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR GO; GO:0006012; P:galactose metabolic process; IEA:HAMAP.
DR Gene3D; 3.30.230.10; -; 1.
DR HAMAP; MF_00246; Galactokinase; 1; -.
DR InterPro; IPR000705; Galactokinase.
DR InterPro; IPR022963; Galactokinase_bac.
DR InterPro; IPR019741; Galactokinase_CS.
DR InterPro; IPR019539; GalKase_gal-bd.
DR InterPro; IPR013750; GHMP_kinase_C_dom.
DR InterPro; IPR006204; GHMP_kinase_N_dom.
DR InterPro; IPR006203; GHMP_knse_ATP-bd_CS.
DR InterPro; IPR006206; Mevalonate/galactokinase.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR Pfam; PF10509; GalKase_gal_bdg; 1.
DR Pfam; PF08544; GHMP_kinases_C; 1.
DR Pfam; PF00288; GHMP_kinases_N; 1.
DR PIRSF; PIRSF000530; Galactokinase; 1.
DR PRINTS; PR00473; GALCTOKINASE.
DR PRINTS; PR00959; MEVGALKINASE.
DR SUPFAM; SSF54211; Ribosomal_S5_D2-typ_fold; 1.
DR TIGRFAMs; TIGR00131; gal_kin; 1.
DR PROSITE; PS00106; GALACTOKINASE; 1.
DR PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE 3: Inferred from homology;
KW ATP-binding; Carbohydrate metabolism; Complete proteome; Cytoplasm;
KW Galactose metabolism; Kinase; Magnesium; Metal-binding;
KW Nucleotide-binding; Transferase.
FT CHAIN 1 382 Galactokinase.
FT /FTId=PRO_1000100839.
FT NP_BIND 124 130 ATP (By similarity).
FT REGION 34 37 Substrate binding (By similarity).
FT ACT_SITE 174 174 Proton acceptor (By similarity).
FT METAL 130 130 Magnesium (By similarity).
FT METAL 162 162 Magnesium (By similarity).
FT BINDING 223 223 Substrate (By similarity).
FT SITE 28 28 Transition state stabilizer (By
FT similarity).
SQ SEQUENCE 382 AA; 41246 MW; 764243641DAC1EBC CRC64;
MNLKEKTRAL FAEIFGYPAT HTIQAPGRVN LIGEHTDYND GFVLPCAIDY QTVISCAPRD
DRTVRVIAAD YDNQVDEFSL DAPIVTHDSQ QWSNYVRGVV KHLQQRNNAF GGVDMVISGN
VPQGAGLSSS ASLEVAVGTV FQQLYHLPLD GAQIALNGQE AENQFVGCNC GIMDQLISAL
GKKDHALLID CRTLGAKAVS MPKGVAVVII NSNFKRTLVG SEYNTRREQC ETGARFFQQP
ALRDVSLEAF NAVASELDPV VAKRVRHVLS ENARTVEAAS ALEKGDLQRM GQLMAESHAS
MRDDFEITVP QIDTLVDIVK ATIGDQGGVR MTGGGFGGCV VALIPEDLVP AVQQAVAQQY
EAKTGIKETF YVCKPSQGAG QC
//
