ID   GCSP_PSESM              Reviewed;         954 AA.
AC   Q887L5;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   01-MAY-2013, entry version 68.
DE   RecName: Full=Glycine dehydrogenase [decarboxylating];
DE            EC=1.4.4.2;
DE   AltName: Full=Glycine cleavage system P-protein;
DE   AltName: Full=Glycine decarboxylase;
GN   Name=gcvP; OrderedLocusNames=PSPTO_1276;
OS   Pseudomonas syringae pv. tomato (strain DC3000).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=223283;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DC3000;
RX   PubMed=12928499; DOI=10.1073/pnas.1731982100;
RA   Buell C.R., Joardar V., Lindeberg M., Selengut J., Paulsen I.T.,
RA   Gwinn M.L., Dodson R.J., DeBoy R.T., Durkin A.S., Kolonay J.F.,
RA   Madupu R., Daugherty S.C., Brinkac L.M., Beanan M.J., Haft D.H.,
RA   Nelson W.C., Davidsen T.M., Zafar N., Zhou L., Liu J., Yuan Q.,
RA   Khouri H.M., Fedorova N.B., Tran B., Russell D., Berry K.J.,
RA   Utterback T.R., Van Aken S.E., Feldblyum T.V., D'Ascenzo M.,
RA   Deng W.-L., Ramos A.R., Alfano J.R., Cartinhour S., Chatterjee A.K.,
RA   Delaney T.P., Lazarowitz S.G., Martin G.B., Schneider D.J., Tang X.,
RA   Bender C.L., White O., Fraser C.M., Collmer A.;
RT   "The complete genome sequence of the Arabidopsis and tomato pathogen
RT   Pseudomonas syringae pv. tomato DC3000.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10181-10186(2003).
CC   -!- FUNCTION: The glycine cleavage system catalyzes the degradation of
CC       glycine. The P protein binds the alpha-amino group of glycine
CC       through its pyridoxal phosphate cofactor; CO(2) is released and
CC       the remaining methylamine moiety is then transferred to the
CC       lipoamide cofactor of the H protein (By similarity).
CC   -!- CATALYTIC ACTIVITY: Glycine + H-protein-lipoyllysine = H-protein-
CC       S-aminomethyldihydrolipoyllysine + CO(2).
CC   -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC   -!- SUBUNIT: The glycine cleavage system is composed of four proteins:
CC       P, T, L and H (By similarity).
CC   -!- SIMILARITY: Belongs to the GcvP family.
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DR   EMBL; AE016853; AAO54801.1; -; Genomic_DNA.
DR   RefSeq; NP_791106.1; NC_004578.1.
DR   ProteinModelPortal; Q887L5; -.
DR   STRING; 223283.PSPTO_1276; -.
DR   EnsemblBacteria; AAO54801; AAO54801; PSPTO_1276.
DR   GeneID; 1182912; -.
DR   KEGG; pst:PSPTO_1276; -.
DR   PATRIC; 19993794; VBIPseSyr93040_1298.
DR   eggNOG; COG1003; -.
DR   HOGENOM; HOG000239369; -.
DR   KO; K00281; -.
DR   OMA; QTMVCDL; -.
DR   ProtClustDB; PRK05367; -.
DR   BioCyc; PSYR223283:GJIX-1301-MONOMER; -.
DR   GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IEA:EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019464; P:glycine decarboxylation via glycine cleavage system; IEA:HAMAP.
DR   Gene3D; 3.40.640.10; -; 2.
DR   HAMAP; MF_00711; GcvP; 1; -.
DR   InterPro; IPR020580; GDC-P_N.
DR   InterPro; IPR020581; GDC_P.
DR   InterPro; IPR003437; GDC_P_homo.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major_sub1.
DR   PANTHER; PTHR11773; PTHR11773; 1.
DR   Pfam; PF02347; GDC-P; 2.
DR   SUPFAM; SSF53383; PyrdxlP-dep_Trfase_major; 2.
DR   TIGRFAMs; TIGR00461; gcvP; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Oxidoreductase; Pyridoxal phosphate.
FT   CHAIN         1    954       Glycine dehydrogenase [decarboxylating].
FT                                /FTId=PRO_0000166929.
FT   MOD_RES     706    706       N6-(pyridoxal phosphate)lysine (By
FT                                similarity).
SQ   SEQUENCE   954 AA;  103604 MW;  503D639E9F6A16A0 CRC64;
     MTDRIELTTA NEFIARHIGP RAADELAMLH TLGFDSIEAL SDSVIPESIK GTSVLNLPAG
     QSEADALASI KAIASKNQLF KTYIGQGYYN THTPAPILRN LLENPAWYTA YTPYQPEISQ
     GRLESLLNFQ TLISDLTGLP IANASLLDEA TAAAEAMTFC KRLSKNKGSQ QFFASSHCHP
     QTLDVLRTRA EPLGITVVVA DETELGDVSD YFGALLQYPA SNGDVFDYRE LAERFHGANA
     LVAVAADLLA LTLLTPPGEF GADVAIGSAQ RFGVPLGFGG PHAAYFSTRD AFKRDMPGRL
     VGVSVDRHGK QALRLAMQTR EQHIRREKAT SNICTAQVLL ANIASMYAVY HGPRGLTQIA
     NRVHHLTAIL AEGLSQLGLN AEQAYFFDSL TLHTGGRTAA LHAAARARHI NLREIDDQRL
     GLSLDETTSQ SAVEVLWDIF ASTGQTLPDF TALAASVKSR LPAALLRQSA ILSHPVFNRY
     HSETELMRYL RKLADKDLAL DRTMIPLGSC TMKLNAASEM IPVTWAEFGN LHPFAPAEQS
     AGYQQLTDEL EAMLCAATGY DAISLQPNAG SQGEYAGLLA IRAYHQSRGD EHRDICLIPS
     SAHGTNPATA NMAGMRVVVT ACDARGNVDI EDLRAKALQH REQLAAIMIT YPSTHGVFEE
     GIREICGIVH DNGGQVYIDG ANMNAMVGLC APGKFGGDVS HLNLHKTFCI PHGGGGPGVG
     PIGVKSHLAP FMPGHARMQR KEGAVCAAPF GSASILPITW MYIRMMGGEG LKRASQLAIL
     NANYISRRLE EHYPVLYTGT NGLVAHECIL DLRPIKDSSG ISVDDVAKRL IDFGFHAPTM
     SFPVAGTLMI EPTESESREE LDRFCDAMIK IREEIRAVED GTLDKDDNPL KNAPHTAAEI
     VGQWSHPYSR EQAVYPVDSL IENKYWPPVG RVDNVFGDRN LVCACPSIES YQEA
//