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Database: UniProt/SWISS-PROT
Entry: GYS_NEUCR
LinkDB: GYS_NEUCR
Original site: GYS_NEUCR 
ID   GYS_NEUCR               Reviewed;         706 AA.
AC   O93869; Q7S7N0; V5IN77;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 2.
DT   30-AUG-2017, entry version 113.
DE   RecName: Full=Glycogen [starch] synthase;
DE            EC=2.4.1.11;
GN   Name=gsy-1; ORFNames=7F4.080, NCU06687;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM
OS   1257 / FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
OC   Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   de Paula R., Terenzi H.F., Bertolini M.C.;
RL   Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V.,
RA   Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J.,
RA   Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the
RT   Neurospora genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
RA   Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
RA   Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C.,
RA   Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
RA   Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
RA   Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S.,
RA   Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
RA   Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
RA   Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Transfers the glycosyl residue from UDP-Glc to the non-
CC       reducing end of alpha-1,4-glucan. Is believed to regulate the
CC       synthesis of glycogen.
CC   -!- CATALYTIC ACTIVITY: UDP-alpha-D-glucose + ((1->4)-alpha-D-
CC       glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).
CC   -!- ENZYME REGULATION: Allosteric activation by glucose-6-phosphate,
CC       and phosphorylation by a cAMP-dependent kinase. {ECO:0000250}.
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 3 family.
CC       {ECO:0000305}.
DR   EMBL; AF056080; AAC98780.2; -; mRNA.
DR   EMBL; BX294020; CAD70912.1; -; Genomic_DNA.
DR   EMBL; CM002240; ESA42591.1; -; Genomic_DNA.
DR   EMBL; CM002240; ESA42592.1; -; Genomic_DNA.
DR   EMBL; CM002240; ESA42593.1; -; Genomic_DNA.
DR   EMBL; CM002240; ESA42594.1; -; Genomic_DNA.
DR   RefSeq; XP_011394695.1; XM_011396393.1.
DR   RefSeq; XP_011394696.1; XM_011396394.1.
DR   RefSeq; XP_011394697.1; XM_011396395.1.
DR   RefSeq; XP_011394698.1; XM_011396396.1.
DR   ProteinModelPortal; O93869; -.
DR   SMR; O93869; -.
DR   CAZy; GT3; Glycosyltransferase Family 3.
DR   PRIDE; O93869; -.
DR   EnsemblFungi; ESA42591; ESA42591; NCU06687.
DR   EnsemblFungi; ESA42592; ESA42592; NCU06687.
DR   EnsemblFungi; ESA42593; ESA42593; NCU06687.
DR   EnsemblFungi; ESA42594; ESA42594; NCU06687.
DR   GeneID; 3877149; -.
DR   KEGG; ncr:NCU06687; -.
DR   EuPathDB; FungiDB:NCU06687; -.
DR   HOGENOM; HOG000160890; -.
DR   InParanoid; O93869; -.
DR   KO; K00693; -.
DR   OMA; KVYFGRW; -.
DR   OrthoDB; EOG092C0XGC; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd03793; GT1_Glycogen_synthase_GSY2_lik; 1.
DR   InterPro; IPR008631; Glycogen_synth.
DR   PANTHER; PTHR10176; PTHR10176; 1.
DR   Pfam; PF05693; Glycogen_syn; 1.
PE   2: Evidence at transcript level;
KW   Allosteric enzyme; Complete proteome; Glycogen biosynthesis;
KW   Glycosyltransferase; Phosphoprotein; Reference proteome; Transferase.
FT   CHAIN         1    706       Glycogen [starch] synthase.
FT                                /FTId=PRO_0000194772.
FT   BINDING      26     26       UDP-glucose. {ECO:0000250}.
SQ   SEQUENCE   706 AA;  80907 MW;  CDF0DB45549FF4BB CRC64;
     MAHDNREPRE VKNHLLFEVA TEVAHRVGGI YSVLKSKAPV TTAEYGDRYT LIGPLNHQSA
     AVEVEELEPS NPELKATIQA MRDRGIGILY GRWLIEGAPR VLLFDTKTAY GYMNEWKTDL
     WNVASIPSPD NDEETNEAIV FGYLVAWFLG EFVCHEKRKA VIAHFHEWLA GVALPLTKKR
     QIDVTTIFTT HATLLGRYLC AGSVDFYNNL QWFDVDAEAG KRGIYHRYCI ERAAAHSCDV
     FTTVSHITAY ESEHLLKRKP DGVLPNGLNV TKFSAMHEFQ NLHQQNKEKI HDFVRGHFYG
     HYDFEPENTL YFFTAGRYEF RNKGVDMFIE SLARLNHRLK TAGSKTTVVA FIIMPAQTTS
     LTVEALKGQA VIKSLRDTVD VIERGIGRRI FERSVKWHEG DPLPEEKELI TSQDRVLLRR
     RLFAMKRHTL PPIVTHNMLN DHEDPILNQI RRVQLFNHPS DRVKIVFHPE FLSSANPVLP
     LDYDDFVRGT HLGVFASYYE PWGYTPAECT VMGVPSITTN LSGFGCYMEE LIENSSDYGI
     YIVDRRSKGV DDSVNQLTQY MFEFTQKSRR QRINQRNRTE RLSDLLDWKR MGMEYVKARQ
     LALRRAYPTS FNGEEEEDFI PGVEQKISRP FSVPGSPRDR TGMMTPGDFA SLQESHEGLS
     TEDYVAWKLP EEEDPEEYPF PLTLKQRTGP GSPLDSIQGL QLNGTR
//
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