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Database: UniProt/SWISS-PROT
Entry: HDAC1_CHICK
LinkDB: HDAC1_CHICK
Original site: HDAC1_CHICK 
ID   HDAC1_CHICK             Reviewed;         480 AA.
AC   P56517;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   22-NOV-2017, entry version 126.
DE   RecName: Full=Histone deacetylase 1;
DE            Short=HD1;
DE            EC=3.5.1.98;
GN   Name=HDAC1; Synonyms=HDAC1A;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Takami Y.;
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Sun J.M., Chen H.Y., Davie J.R.;
RL   Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for the deacetylation of lysine residues on
CC       the N-terminal part of the core histones (H2A, H2B, H3 and H4).
CC       Histone deacetylation gives a tag for epigenetic repression and
CC       plays an important role in transcriptional regulation, cell cycle
CC       progression and developmental events. Histone deacetylases act via
CC       the formation of large multiprotein complexes (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of
CC       a histone to yield a deacetylated histone.
CC   -!- SUBUNIT: Forms a complex with RBAP48. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the histone deacetylase family. HD type 1
CC       subfamily. {ECO:0000305}.
DR   EMBL; AF039751; AAB96923.1; -; mRNA.
DR   EMBL; AF043328; AAB99850.1; -; mRNA.
DR   EMBL; AF044169; AAC00504.1; -; mRNA.
DR   RefSeq; NP_989487.1; NM_204156.1.
DR   UniGene; Gga.10603; -.
DR   ProteinModelPortal; P56517; -.
DR   SMR; P56517; -.
DR   BioGrid; 675010; 2.
DR   STRING; 9031.ENSGALP00000005212; -.
DR   PaxDb; P56517; -.
DR   PRIDE; P56517; -.
DR   Ensembl; ENSGALT00000084635; ENSGALP00000059784; ENSGALG00000003297.
DR   GeneID; 373961; -.
DR   KEGG; gga:373961; -.
DR   CTD; 3065; -.
DR   eggNOG; KOG1342; Eukaryota.
DR   eggNOG; COG0123; LUCA.
DR   GeneTree; ENSGT00530000062889; -.
DR   HOGENOM; HOG000225180; -.
DR   HOVERGEN; HBG057112; -.
DR   InParanoid; P56517; -.
DR   KO; K06067; -.
DR   OMA; KCVEFVR; -.
DR   OrthoDB; EOG091G067J; -.
DR   PhylomeDB; P56517; -.
DR   TreeFam; TF106171; -.
DR   BRENDA; 3.5.1.98; 1306.
DR   Reactome; R-GGA-1538133; G0 and Early G1.
DR   Reactome; R-GGA-201722; Formation of the beta-catenin:TCF transactivating complex.
DR   Reactome; R-GGA-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity.
DR   Reactome; R-GGA-3769402; Deactivation of the beta-catenin transactivating complex.
DR   Reactome; R-GGA-4551638; SUMOylation of chromatin organization proteins.
DR   Reactome; R-GGA-73762; RNA Polymerase I Transcription Initiation.
DR   Reactome; R-GGA-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
DR   Reactome; R-GGA-8943724; Regulation of PTEN gene transcription.
DR   Reactome; R-GGA-983231; Factors involved in megakaryocyte development and platelet production.
DR   PRO; PR:P56517; -.
DR   Proteomes; UP000000539; Chromosome 23.
DR   Bgee; ENSGALG00000003297; -.
DR   GO; GO:0005737; C:cytoplasm; TAS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0000118; C:histone deacetylase complex; TAS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; TAS:UniProtKB.
DR   GO; GO:0016581; C:NuRD complex; IEA:Ensembl.
DR   GO; GO:0043234; C:protein complex; IEA:Ensembl.
DR   GO; GO:0016580; C:Sin3 complex; IEA:Ensembl.
DR   GO; GO:0033613; F:activating transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001046; F:core promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0004407; F:histone deacetylase activity; TAS:UniProtKB.
DR   GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR   GO; GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:UniProtKB-EC.
DR   GO; GO:0051059; F:NF-kappaB binding; IEA:Ensembl.
DR   GO; GO:0031492; F:nucleosomal DNA binding; IEA:Ensembl.
DR   GO; GO:0002039; F:p53 binding; IEA:Ensembl.
DR   GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0001103; F:RNA polymerase II repressing transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001106; F:RNA polymerase II transcription corepressor activity; IEA:Ensembl.
DR   GO; GO:0008134; F:transcription factor binding; TAS:UniProtKB.
DR   GO; GO:0043044; P:ATP-dependent chromatin remodeling; IEA:Ensembl.
DR   GO; GO:0006325; P:chromatin organization; TAS:UniProtKB.
DR   GO; GO:0070933; P:histone H4 deacetylation; IEA:Ensembl.
DR   GO; GO:0006346; P:methylation-dependent chromatin silencing; IEA:Ensembl.
DR   GO; GO:0043922; P:negative regulation by host of viral transcription; IEA:Ensembl.
DR   GO; GO:0060766; P:negative regulation of androgen receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0010870; P:positive regulation of receptor biosynthetic process; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.800.20; -; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR003084; His_deacetylse_1.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625; PTHR10625; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PIRSF; PIRSF037913; His_deacetylse_1; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   PRINTS; PR01271; HISDACETLASE.
DR   SUPFAM; SSF52768; SSF52768; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Complete proteome; Hydrolase; Nucleus;
KW   Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    480       Histone deacetylase 1.
FT                                /FTId=PRO_0000114689.
FT   REGION        9    321       Histone deacetylase.
FT   COMPBIAS    299    302       Poly-Gly.
FT   COMPBIAS    396    399       Poly-Glu.
FT   COMPBIAS    446    453       Poly-Glu.
FT   ACT_SITE    141    141       {ECO:0000250}.
FT   CONFLICT      3      4       LT -> VM (in Ref. 2; AAB99850).
FT                                {ECO:0000305}.
SQ   SEQUENCE   480 AA;  54939 MW;  82C78CE285C779D9 CRC64;
     MALTQGTKRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN
     AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSAGGSVAS
     AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG
     DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI
     FKPVISKVME TFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG
     GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE
     KIKQRLFENL RMLPHAPGVQ MQPIPEDAVQ EDSGDEEEED PEKRISIRNS DKRISCDEEF
     SDSEDEGEGG RKNVANFKKA KRVKTEEEKE EEEKKDEKEE EKAKEEKAEP KGVKEETKST
//
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