ID HPPD1_ASPFU Reviewed; 403 AA.
AC Q4WHU1;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-APR-2013, entry version 64.
DE RecName: Full=Probable 4-hydroxyphenylpyruvate dioxygenase 1;
DE Short=4HPPD 1;
DE Short=HPD 1;
DE Short=HPPDase 1;
DE EC=1.13.11.27;
GN ORFNames=AFUA_2G04200;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae;
OC mitosporic Trichocomaceae; Aspergillus.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S.,
RA Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W.,
RA Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S.,
RA Farman M.L., Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R.,
RA Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A.,
RA Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J.,
RA Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J.,
RA Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S.,
RA Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A.,
RA Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M.,
RA Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I.,
RA Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M.,
RA Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S.,
RA Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J.,
RA White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K.,
RA Machida M., Hall N., Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- CATALYTIC ACTIVITY: 4-hydroxyphenylpyruvate + O(2) = homogentisate
CC + CO(2).
CC -!- COFACTOR: Binds 1 iron ion per subunit (By similarity).
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 3/6.
CC -!- SIMILARITY: Belongs to the 4HPPD family.
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DR EMBL; AAHF01000008; EAL87514.1; -; Genomic_DNA.
DR RefSeq; XP_749552.1; XM_744459.1.
DR ProteinModelPortal; Q4WHU1; -.
DR STRING; 5085.CADAFUAP00003294; -.
DR EnsemblFungi; CADAFUAT00003294; CADAFUAP00003294; CADAFUAG00003294.
DR GeneID; 3507145; -.
DR KEGG; afm:AFUA_2G04200; -.
DR eggNOG; COG3185; -.
DR HOGENOM; HOG000188687; -.
DR KO; K00457; -.
DR OMA; HMVGNVG; -.
DR OrthoDB; EOG4CC78T; -.
DR UniPathway; UPA00139; UER00362.
DR GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR PANTHER; PTHR11959; PTHR11959; 1.
DR Pfam; PF00903; Glyoxalase; 1.
DR PIRSF; PIRSF009283; HPP_dOase; 1.
DR TIGRFAMs; TIGR01263; 4HPPD; 1.
PE 3: Inferred from homology;
KW Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW Phenylalanine catabolism; Reference proteome; Tyrosine catabolism.
FT CHAIN 1 403 Probable 4-hydroxyphenylpyruvate
FT dioxygenase 1.
FT /FTId=PRO_0000088401.
FT METAL 204 204 Iron (By similarity).
FT METAL 287 287 Iron (By similarity).
FT METAL 370 370 Iron (By similarity).
SQ SEQUENCE 403 AA; 45534 MW; 849FED016DA354AC CRC64;
MAPSAISTSP PPTDRVSSSL ASYKGYDHVH WYVGNAKQAA SYYITRMGFK RIAYRGLETG
CRSVCSHVVR NGDITFILTS PLRSLDQVDR FPPEEQELLK EIHAHLEKHG DGVKDVAFEV
DSVDSVFYAA TNNGAKIVSQ PRTLEDDNGQ VRVATIQTYG ETTHTLVERG SYHGAFLPGY
RMETGVEDPI SQLLPGVHLN RIDHCVGNQD WDEMDKVCEY YEKALGFHRF WSVDDKQICT
EYSALKSIVM ASPNEVVKMP INEPAKGKKQ SQIEEYVDFY NGAGVQHIAL LTDDIIRDIT
NLKARGVEFI KVPDTYYEDI KVRLKKAGLT LHEDFETIRS LDILIDFDEG GYLLQLFTKH
LMDRPTVFIE IIQRHNFSGF GAGNFKSLFE AIEREQALRG NLV
//
