GenomeNet

Database: UniProt/SWISS-PROT
Entry: HXK1_SCHPO
LinkDB: HXK1_SCHPO
Original site: HXK1_SCHPO 
ID   HXK1_SCHPO              Reviewed;         484 AA.
AC   Q09756;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   28-FEB-2018, entry version 137.
DE   RecName: Full=Hexokinase-1;
DE            EC=2.7.1.1;
GN   Name=hxk1; ORFNames=SPAC24H6.04;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8549830; DOI=10.1016/0014-5793(95)01451-9;
RA   Petit T., Blazquez M.A., Gancedo C.;
RT   "Schizosaccharomyces pombe possesses an unusual and a conventional
RT   hexokinase: biochemical and molecular characterization of both
RT   hexokinases.";
RL   FEBS Lett. 378:185-189(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Has low affinity for glucose and some of its analogs.
CC   -!- CATALYTIC ACTIVITY: ATP + D-hexose = ADP + D-hexose 6-phosphate.
CC   -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC   -!- SUBUNIT: Monomer.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01084, ECO:0000305}.
DR   EMBL; X92894; CAA63487.1; -; mRNA.
DR   EMBL; CU329670; CAA90848.1; -; Genomic_DNA.
DR   PIR; S68694; S68694.
DR   RefSeq; NP_592948.1; NM_001018349.2.
DR   ProteinModelPortal; Q09756; -.
DR   SMR; Q09756; -.
DR   BioGrid; 279088; 7.
DR   STRING; 4896.SPAC24H6.04.1; -.
DR   iPTMnet; Q09756; -.
DR   SwissPalm; Q09756; -.
DR   MaxQB; Q09756; -.
DR   PaxDb; Q09756; -.
DR   PRIDE; Q09756; -.
DR   EnsemblFungi; SPAC24H6.04.1; SPAC24H6.04.1:pep; SPAC24H6.04.
DR   GeneID; 2542634; -.
DR   KEGG; spo:SPAC24H6.04; -.
DR   EuPathDB; FungiDB:SPAC24H6.04; -.
DR   PomBase; SPAC24H6.04; hxk1.
DR   HOGENOM; HOG000162670; -.
DR   InParanoid; Q09756; -.
DR   KO; K00844; -.
DR   OMA; ERQFFRA; -.
DR   OrthoDB; EOG092C2JW4; -.
DR   PhylomeDB; Q09756; -.
DR   BRENDA; 2.7.1.1; 5613.
DR   Reactome; R-SPO-170822; Regulation of Glucokinase by Glucokinase Regulatory Protein.
DR   Reactome; R-SPO-6798695; Neutrophil degranulation.
DR   Reactome; R-SPO-70171; Glycolysis.
DR   SABIO-RK; Q09756; -.
DR   UniPathway; UPA00242; -.
DR   PRO; PR:Q09756; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008865; F:fructokinase activity; IDA:PomBase.
DR   GO; GO:0004340; F:glucokinase activity; IDA:PomBase.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IDA:PomBase.
DR   GO; GO:0019158; F:mannokinase activity; IDA:PomBase.
DR   GO; GO:0061621; P:canonical glycolysis; IC:PomBase.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IBA:GO_Central.
DR   GO; GO:0006002; P:fructose 6-phosphate metabolic process; IDA:PomBase.
DR   GO; GO:0006000; P:fructose metabolic process; IDA:PomBase.
DR   GO; GO:0051156; P:glucose 6-phosphate metabolic process; IDA:PomBase.
DR   GO; GO:0006006; P:glucose metabolic process; IDA:PomBase.
DR   GO; GO:0006096; P:glycolytic process; IBA:GO_Central.
DR   GO; GO:0006013; P:mannose metabolic process; IDA:PomBase.
DR   GO; GO:0009051; P:pentose-phosphate shunt, oxidative branch; TAS:PomBase.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Glycolysis; Kinase;
KW   Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN         1    484       Hexokinase-1.
FT                                /FTId=PRO_0000197609.
FT   DOMAIN       25    465       Hexokinase. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01084}.
FT   REGION       79    212       Hexokinase small subdomain.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01084}.
FT   REGION      154    180       Glucose-binding. {ECO:0000255}.
FT   REGION      213    454       Hexokinase large subdomain.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01084}.
FT   BINDING     115    115       ATP. {ECO:0000250}.
SQ   SEQUENCE   484 AA;  53598 MW;  165500F19E6BBB0F CRC64;
     MSLHDAYHWP SRTPSRKGSN IKLNKTLQDH LDELEEQFTI PTELLHRVTD RFVSELYKGL
     TTNPGDVPMV PTWIIGTPDG NEHGSYLALD LGGTNLRVCA VEVQGNGKFD ITQSKYRLPQ
     ELKVGTREAL FDYIADCIKK FVEEVHPGKS QNLEIGFTFS YPCVQRSIND ASLVAWTKGF
     DIDGVEGESV GPLLSAALKR VGCNNVRLNA ILSDTTGTLV ASNYASPGTE IGVIFGTGCN
     ACYIEKFSEI PKLHKYDFPE DMNMIINCEW CDFDNQHVVL PRTKYDVAID EESPRPGLQT
     YEKMIAGCYL GDILRRILLD LYEQGALFNG QDVTKIRDPL AMDTSVLSAI EVDPFENLDE
     TQTLFEETYG LKTTEEERQF IRRACELIGT RSARLSACGV CALVRKMNKP SMIVGTDGSV
     YNLYPRFKDR LAQAFKDILG EEIGSKVVTI PAEDGSGVGA ALVSALEAKG KALTSDILAE
     HLKN
//
DBGET integrated database retrieval system