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Entry: HXK2_ORYSJ B9FH43_ORYSJ
LinkDB: HXK2_ORYSJ B9FH43_ORYSJ
Original site: HXK2_ORYSJ B9FH43_ORYSJ 
ID   HXK2_ORYSJ              Reviewed;         494 AA.
AC   Q2KNB9; Q6I5H8;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   30-AUG-2017, entry version 63.
DE   RecName: Full=Hexokinase-2;
DE            EC=2.7.1.1;
DE   AltName: Full=Hexokinase-3;
GN   Name=HXK2; Synonyms=HXK3;
GN   OrderedLocusNames=Os05g0532600, LOC_Os05g45590;
GN   ORFNames=OSJNBa0053E05.8;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY,
RP   DEVELOPMENTAL STAGE, INDUCTION, AND NOMENCLATURE.
RC   STRAIN=cv. Jinmi;
RX   PubMed=16552590; DOI=10.1007/s00425-006-0251-y;
RA   Cho J.-I., Ryoo N., Ko S., Lee S.-K., Lee J., Jung K.-H., Lee Y.-H.,
RA   Bhoo S.H., Winderickx J., An G., Hahn T.-R., Jeon J.-S.;
RT   "Structure, expression, and functional analysis of the hexokinase gene
RT   family in rice (Oryza sativa L.).";
RL   Planta 224:598-611(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Zhonghua 15; TISSUE=Flower;
RA   Wang Y.D., Cheng W., Wang X.S., Zhou X.J.;
RT   "The hexokinase gene family in rice.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16261349; DOI=10.1007/s00438-005-0039-y;
RA   Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J.,
RA   Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S.,
RA   Shaw J.-F., Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.;
RT   "A fine physical map of the rice chromosome 5.";
RL   Mol. Genet. Genomics 274:337-345(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H.,
RA   McCombie W.R., Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S.,
RA   Childs K.L., Davidson R.M., Lin H., Quesada-Ocampo L.,
RA   Vaillancourt B., Sakai H., Lee S.S., Kim J., Numa H., Itoh T.,
RA   Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using
RT   next generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
CC   -!- FUNCTION: Fructose and glucose phosphorylating enzyme.
CC       {ECO:0000269|PubMed:16552590}.
CC   -!- CATALYTIC ACTIVITY: ATP + D-hexose = ADP + D-hexose 6-phosphate.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaves, flowers, immature
CC       seeds, endosperm and seed coat. {ECO:0000269|PubMed:16552590}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during flower development until 15
CC       days after flowering. {ECO:0000269|PubMed:16552590}.
CC   -!- INDUCTION: By glucose or fructose treatment in leaves.
CC       {ECO:0000269|PubMed:16552590}.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01084, ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT47078.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; DQ116384; AAZ93619.1; -; mRNA.
DR   EMBL; AY884166; AAX68419.1; -; mRNA.
DR   EMBL; AC121365; AAT47078.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_015637797.1; XM_015782311.1.
DR   UniGene; Os.17535; -.
DR   ProteinModelPortal; Q2KNB9; -.
DR   SMR; Q2KNB9; -.
DR   STRING; 39947.LOC_Os05g45590.1; -.
DR   PaxDb; Q2KNB9; -.
DR   PRIDE; Q2KNB9; -.
DR   GeneID; 4339420; -.
DR   KEGG; osa:4339420; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   eggNOG; COG5026; LUCA.
DR   HOGENOM; HOG000162670; -.
DR   InParanoid; Q2KNB9; -.
DR   KO; K00844; -.
DR   BRENDA; 2.7.1.1; 4460.
DR   Proteomes; UP000059680; Chromosome 5.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008865; F:fructokinase activity; IBA:GO_Central.
DR   GO; GO:0004340; F:glucokinase activity; IBA:GO_Central.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0019158; F:mannokinase activity; IBA:GO_Central.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IBA:GO_Central.
DR   GO; GO:0006096; P:glycolytic process; IBA:GO_Central.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Glycolysis; Kinase;
KW   Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN         1    494       Hexokinase-2.
FT                                /FTId=PRO_0000247565.
FT   DOMAIN       32    483       Hexokinase. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01084}.
FT   NP_BIND      98    103       ATP. {ECO:0000255}.
FT   REGION       87    225       Hexokinase small subdomain.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01084}.
FT   REGION      168    194       Glucose-binding. {ECO:0000255}.
FT   REGION      226    472       Hexokinase large subdomain.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01084}.
FT   COMPBIAS      4     14       Poly-Ala.
SQ   SEQUENCE   494 AA;  53626 MW;  CBD4744352238E0D CRC64;
     MRKAAAAAVA AAAAVGVALL VRRQLREAKR WGRADAVLRE LEERCAAPPG RLRQVADAMA
     VEMHAGLASE GGSKLKMIIS YVDALPSGEE KGVFYALDLG GTNFRVLRVQ LGGKEGRVIK
     QEHDEISIPP HLMTGGSNEL FDFIASSLAK FVASEGEDFH LAEGRQRELG FTFSFPVKQT
     SIASGTLINW TKGFSIDETV GEDVVTELTK ALERQGLDMK VTALINDTIG TLAGGRYDDN
     DVIAAVILGT GTNAAYVERA NAIPKWHDLL PKSGDMVINM EWGNFRSSHL PLTEFDQALD
     AESLNPGEQV YEKLISGMYL GEIVRRVLLK MAEEASLFGD EVPPKLKIPF IIRTPYMSMM
     HCDRSPDLRT VGAKLKDILG VQNTSLKTRR LVVDVCDIVA KRAAHLAAAG IHGILKKLGR
     DVPNTDKQRT VIAVDGGLYE HYTIFAECVE STLRDMLGED VSSTIVIKLA KDGSGIGAAL
     LAAAHSQYRE AEEL
//
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Ontology (8)   
   GO (8)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   UniGene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (4)   
   EMBL (4)   
Protein domain (8)   
   InterPro (3)   
   Pfam (2)   
   PROSITE (3)   
Literature (4)   
   PubMed (4)   
Enzyme (1)   
   BRENDA (1)   
All databases (31)   

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ID   B9FH43_ORYSJ            Unreviewed;       494 AA.
AC   B9FH43;
DT   24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   24-MAR-2009, sequence version 1.
DT   30-AUG-2017, entry version 55.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN   ORFNames=OsJ_19321 {ECO:0000313|EMBL:EEE64471.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947 {ECO:0000313|EMBL:EEE64471.1};
RN   [1] {ECO:0000313|EMBL:EEE64471.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H.,
RA   Cong L., Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J.,
RA   Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X.,
RA   Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y.,
RA   Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J.,
RA   Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y.,
RA   Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y.,
RA   Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z.,
RA   Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T.,
RA   Chen C., Chen H., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N.,
RA   Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W.,
RA   Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L.,
RA   Zheng W., Hao B., Liu S., Wang W., Yuan L., Cao M., McDermott J.,
RA   Samudrala R., Wang J., Wong G.K., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [2] {ECO:0000313|EMBL:EEE64471.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Wang J., Li R., Fan W., Huang Q., Zhang J., Zhou Y., Hu Y., Zi S.,
RA   Li J., Ni P., Zheng H., Zhang Y., Zhao M., Hao Q., McDermott J.,
RA   Samudrala R., Kristiansen K., Wong G.K.-S.;
RT   "Improved gene annotation of the rice (Oryza sativa) genomes.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672880}.
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DR   EMBL; CM000142; EEE64471.1; -; Genomic_DNA.
DR   RefSeq; XP_015637797.1; XM_015782311.1.
DR   UniGene; Os.17535; -.
DR   ProteinModelPortal; B9FH43; -.
DR   SMR; B9FH43; -.
DR   PaxDb; B9FH43; -.
DR   GeneID; 4339420; -.
DR   KEGG; osa:4339420; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   eggNOG; COG5026; LUCA.
DR   KO; K00844; -.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672869};
KW   Glycolysis {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672871};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672883};
KW   Transferase {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       39    237       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      244    483       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   494 AA;  53626 MW;  CBD4744352238E0D CRC64;
     MRKAAAAAVA AAAAVGVALL VRRQLREAKR WGRADAVLRE LEERCAAPPG RLRQVADAMA
     VEMHAGLASE GGSKLKMIIS YVDALPSGEE KGVFYALDLG GTNFRVLRVQ LGGKEGRVIK
     QEHDEISIPP HLMTGGSNEL FDFIASSLAK FVASEGEDFH LAEGRQRELG FTFSFPVKQT
     SIASGTLINW TKGFSIDETV GEDVVTELTK ALERQGLDMK VTALINDTIG TLAGGRYDDN
     DVIAAVILGT GTNAAYVERA NAIPKWHDLL PKSGDMVINM EWGNFRSSHL PLTEFDQALD
     AESLNPGEQV YEKLISGMYL GEIVRRVLLK MAEEASLFGD EVPPKLKIPF IIRTPYMSMM
     HCDRSPDLRT VGAKLKDILG VQNTSLKTRR LVVDVCDIVA KRAAHLAAAG IHGILKKLGR
     DVPNTDKQRT VIAVDGGLYE HYTIFAECVE STLRDMLGED VSSTIVIKLA KDGSGIGAAL
     LAAAHSQYRE AEEL
//
  All links  
Ontology (6)   
   GO (6)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   UniGene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (6)   
   InterPro (3)   
   Pfam (2)   
   PROSITE (1)   
Literature (1)   
   PubMed (1)   
All databases (19)   

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