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Database: UniProt/SWISS-PROT
Entry: K6PF_MYCBO
LinkDB: K6PF_MYCBO
Original site: K6PF_MYCBO 
ID   K6PF_MYCBO              Reviewed;         343 AA.
AC   P65691; O53257;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   16-APR-2014, entry version 67.
DE   RecName: Full=6-phosphofructokinase;
DE            Short=Phosphofructokinase;
DE            EC=2.7.1.11;
DE   AltName: Full=Phosphohexokinase;
GN   Name=pfkA; OrderedLocusNames=Mb3035c;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H.,
RA   Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S.,
RA   Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R.,
RA   Parkhill J., Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
CC   -!- CATALYTIC ACTIVITY: ATP + D-fructose 6-phosphate = ADP + D-
CC       fructose 1,6-bisphosphate.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 3/4.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the phosphofructokinase family.
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DR   EMBL; BX248344; CAD96722.1; -; Genomic_DNA.
DR   RefSeq; NP_856680.1; NC_002945.3.
DR   ProteinModelPortal; P65691; -.
DR   SMR; P65691; 2-335.
DR   STRING; 233413.Mb3035c; -.
DR   EnsemblBacteria; CAD96722; CAD96722; Mb3035c.
DR   GeneID; 1093228; -.
DR   KEGG; mbo:Mb3035c; -.
DR   PATRIC; 18008410; VBIMycBov88188_3335.
DR   eggNOG; COG0205; -.
DR   HOGENOM; HOG000248869; -.
DR   KO; K00850; -.
DR   OMA; HRIMLLE; -.
DR   OrthoDB; EOG644ZRM; -.
DR   ProtClustDB; PRK03202; -.
DR   UniPathway; UPA00109; UER00182.
DR   GO; GO:0005945; C:6-phosphofructokinase complex; IEA:InterPro.
DR   GO; GO:0003872; F:6-phosphofructokinase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006002; P:fructose 6-phosphate metabolic process; IEA:InterPro.
DR   GO; GO:0006096; P:glycolysis; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00339; Phosphofructokinase; 1.
DR   InterPro; IPR012003; ATP_PFK_prok.
DR   InterPro; IPR012829; PFK.
DR   InterPro; IPR022953; Phosphofructokinase.
DR   InterPro; IPR015912; Phosphofructokinase_CS.
DR   InterPro; IPR000023; Phosphofructokinase_dom.
DR   Pfam; PF00365; PFK; 1.
DR   PIRSF; PIRSF000532; ATP_PFK_prok; 1.
DR   PRINTS; PR00476; PHFRCTKINASE.
DR   SUPFAM; SSF53784; SSF53784; 1.
DR   TIGRFAMs; TIGR02483; PFK_mixed; 1.
DR   PROSITE; PS00433; PHOSPHOFRUCTOKINASE; 1.
PE   3: Inferred from homology;
KW   Allosteric enzyme; ATP-binding; Complete proteome; Cytoplasm;
KW   Glycolysis; Kinase; Magnesium; Metal-binding; Nucleotide-binding;
KW   Transferase.
FT   CHAIN         1    343       6-phosphofructokinase.
FT                                /FTId=PRO_0000111969.
FT   NP_BIND      20     24       ATP (By similarity).
FT   NP_BIND     155    159       ATP (By similarity).
FT   NP_BIND     172    188       ATP (By similarity).
FT   ACT_SITE    128    128       Proton acceptor (By similarity).
FT   METAL       186    186       Magnesium; via carbonyl oxygen (By
FT                                similarity).
FT   BINDING     163    163       Substrate (By similarity).
FT   BINDING     267    267       Substrate (By similarity).
FT   BINDING     273    273       Substrate (By similarity).
FT   BINDING     276    276       Substrate (By similarity).
SQ   SEQUENCE   343 AA;  36880 MW;  826E5FF16A6ECABA CRC64;
     MRIGVLTGGG DCPGLNAVIR AVVRTCHARY GSSVVGFQNG FRGLLENRRV QLHNDDRNDR
     LLAKGGTMLG TARVHPDKLR AGLPQIMQTL DDNGIDVLIP IGGEGTLTAA SWLSEENVPV
     VGVPKTIDND IDCTDVTFGH DTALTVATEA IDRLHSTAES HERVMLVEVM GRHAGWIALN
     AGLASGAHMT LIPEQPFDIE EVCRLVKGRF QRGDSHFICV VAEGAKPAPG TIMLREGGLD
     EFGHERFTGV AAQLAVEVEK RINKDVRVTV LGHIQRGGTP TAYDRVLATR FGVNAADAAH
     AGEYGQMVTL RGQDIGRVPL ADAVRKLKLV PQSRYDDAAA FFG
//
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