ID KHSE_BURP1 Reviewed; 331 AA.
AC Q3JK86;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 01-MAY-2013, entry version 51.
DE RecName: Full=Homoserine kinase;
DE Short=HK;
DE Short=HSK;
DE EC=2.7.1.39;
GN Name=thrB; OrderedLocusNames=BURPS1710b_A0859;
OS Burkholderia pseudomallei (strain 1710b).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=320372;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1710b;
RA Woods D.E., Nierman W.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-
CC homoserine.
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC threonine from L-aspartate: step 4/5.
CC -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABA51556.1; Type=Erroneous initiation;
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DR EMBL; CP000125; ABA51556.1; ALT_INIT; Genomic_DNA.
DR RefSeq; YP_336017.1; NC_007435.1.
DR ProteinModelPortal; Q3JK86; -.
DR STRING; 320372.BURPS1710b_A0859; -.
DR EnsemblBacteria; ABA51556; ABA51556; BURPS1710b_A0859.
DR GeneID; 3694063; -.
DR KEGG; bpm:BURPS1710b_A0859; -.
DR PATRIC; 19242133; VBIBurPse115837_4904.
DR eggNOG; COG2334; -.
DR HOGENOM; HOG000004810; -.
DR KO; K02204; -.
DR ProtClustDB; PRK05231; -.
DR UniPathway; UPA00050; UER00064.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004413; F:homoserine kinase activity; IEA:HAMAP.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00301; Homoser_kinase_2; 1; -.
DR InterPro; IPR002575; Aminoglycoside_PTrfase.
DR InterPro; IPR005280; Homoserine_kinase_ThrB.
DR InterPro; IPR011009; Kinase-like_dom.
DR Pfam; PF01636; APH; 1.
DR SUPFAM; SSF56112; Kinase_like; 1.
DR TIGRFAMs; TIGR00938; thrB_alt; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; ATP-binding; Complete proteome; Kinase;
KW Nucleotide-binding; Threonine biosynthesis; Transferase.
FT CHAIN 1 331 Homoserine kinase.
FT /FTId=PRO_0000322239.
SQ SEQUENCE 331 AA; 36759 MW; 6D14A50910891BD5 CRC64;
MAVFTAVSNA DLALWMRHYD LGDVVAFRGI PSGIENSNFF LTTTRGEYVL TIFENLTAGQ
LPFYVDLMSH LAKHGVPVPA PVARDDGTLF GELHGKPAAI VTKLEGAAQL APGVEHCVEV
GQMLARMHLA GRDYPRHQPN LRSLPWWRDT VPAIAPFVTG EQRALLEGEL AHQAAFFASD
DYAALPEGPC HCDLFRDNAL FAHAEPDTGH SVRLGGFFDF YFAGCDKWLF DVAVTVNDWC
VDLPTGALDA ARADALLRAY QTVRPFTAGE RRHWGDMLRA GAYRFWVSRL YDFHLPRAAQ
MLKPHDPGHF ERILRERIAH AGALPETHAC N
//
