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Database: UniProt/SWISS-PROT
Entry: KHSE_BURP1
LinkDB: KHSE_BURP1
Original site: KHSE_BURP1 
ID   KHSE_BURP1              Reviewed;         331 AA.
AC   Q3JK86;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   19-FEB-2014, entry version 55.
DE   RecName: Full=Homoserine kinase;
DE            Short=HK;
DE            Short=HSK;
DE            EC=2.7.1.39;
GN   Name=thrB; OrderedLocusNames=BURPS1710b_A0859;
OS   Burkholderia pseudomallei (strain 1710b).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=320372;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1710b;
RA   Woods D.E., Nierman W.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-
CC       homoserine.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 4/5.
CC   -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABA51556.1; Type=Erroneous initiation;
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DR   EMBL; CP000125; ABA51556.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_336017.1; NC_007435.1.
DR   ProteinModelPortal; Q3JK86; -.
DR   STRING; 320372.BURPS1710b_A0859; -.
DR   EnsemblBacteria; ABA51556; ABA51556; BURPS1710b_A0859.
DR   GeneID; 3694063; -.
DR   KEGG; bpm:BURPS1710b_A0859; -.
DR   PATRIC; 19242133; VBIBurPse115837_4904.
DR   eggNOG; COG2334; -.
DR   HOGENOM; HOG000004810; -.
DR   KO; K02204; -.
DR   OrthoDB; EOG6BW4W1; -.
DR   ProtClustDB; PRK05231; -.
DR   BioCyc; BPSE320372:GBYB-4657-MONOMER; -.
DR   UniPathway; UPA00050; UER00064.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00301; Homoser_kinase_2; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR005280; Homoserine_kinase_ThrB.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   TIGRFAMs; TIGR00938; thrB_alt; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Complete proteome; Kinase;
KW   Nucleotide-binding; Threonine biosynthesis; Transferase.
FT   CHAIN         1    331       Homoserine kinase.
FT                                /FTId=PRO_0000322239.
SQ   SEQUENCE   331 AA;  36759 MW;  6D14A50910891BD5 CRC64;
     MAVFTAVSNA DLALWMRHYD LGDVVAFRGI PSGIENSNFF LTTTRGEYVL TIFENLTAGQ
     LPFYVDLMSH LAKHGVPVPA PVARDDGTLF GELHGKPAAI VTKLEGAAQL APGVEHCVEV
     GQMLARMHLA GRDYPRHQPN LRSLPWWRDT VPAIAPFVTG EQRALLEGEL AHQAAFFASD
     DYAALPEGPC HCDLFRDNAL FAHAEPDTGH SVRLGGFFDF YFAGCDKWLF DVAVTVNDWC
     VDLPTGALDA ARADALLRAY QTVRPFTAGE RRHWGDMLRA GAYRFWVSRL YDFHLPRAAQ
     MLKPHDPGHF ERILRERIAH AGALPETHAC N
//
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