GenomeNet

Database: UniProt/SWISS-PROT
Entry: KHSE_BURXL
LinkDB: KHSE_BURXL
Original site: KHSE_BURXL 
ID   KHSE_BURXL              Reviewed;         331 AA.
AC   Q13RY4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   19-FEB-2014, entry version 52.
DE   RecName: Full=Homoserine kinase;
DE            Short=HK;
DE            Short=HSK;
DE            EC=2.7.1.39;
GN   Name=thrB; OrderedLocusNames=Bxeno_B0187; ORFNames=Bxe_B2840;
OS   Burkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia.
OX   NCBI_TaxID=266265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400;
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-
CC       homoserine.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 4/5.
CC   -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000271; ABE33155.1; -; Genomic_DNA.
DR   RefSeq; YP_552505.1; NC_007952.1.
DR   ProteinModelPortal; Q13RY4; -.
DR   STRING; 266265.Bxe_B2840; -.
DR   EnsemblBacteria; ABE33155; ABE33155; Bxe_B2840.
DR   GeneID; 4006561; -.
DR   KEGG; bxe:Bxe_B2840; -.
DR   PATRIC; 19335156; VBIBurXen52548_4853.
DR   eggNOG; COG2334; -.
DR   HOGENOM; HOG000004810; -.
DR   KO; K02204; -.
DR   OMA; FYNACSG; -.
DR   OrthoDB; EOG6BW4W1; -.
DR   ProtClustDB; PRK05231; -.
DR   BioCyc; BXEN266265:GJII-4797-MONOMER; -.
DR   UniPathway; UPA00050; UER00064.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00301; Homoser_kinase_2; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR005280; Homoserine_kinase_ThrB.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   TIGRFAMs; TIGR00938; thrB_alt; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Complete proteome; Kinase;
KW   Nucleotide-binding; Threonine biosynthesis; Transferase.
FT   CHAIN         1    331       Homoserine kinase.
FT                                /FTId=PRO_0000300791.
SQ   SEQUENCE   331 AA;  37328 MW;  48C1A92E324F2777 CRC64;
     MAVFTAVTEP QLAEWMRHYD LGDVVEFRGI SSGIENSNFF LTTTRGEYVL TIFEKLTAEQ
     LPFYLDLMRH LAAHRVPVPD PMPREDGALF GLLQGKPAAI VTRLEGAPEL APGVEHCIEV
     GQMLARMHLA GRDYPAYQPN LRSLPWWKET VPTILPFLEG GQRELLSSEL AYQEAFFASA
     DYAALPEGPC HADLFRDNAM FAHAEPGTGH EVRLGGFFDF YFAGCDKWLF DVAVTVNDWC
     VDLATGKLDA ARTEAMLRAY QTVRPFTAEE NRHWGDMLRA GAYRFWVSRL YDFHLPRAAE
     LLKPHDPGHF ERILRERLSG VALPGIHTSC N
//
DBGET integrated database retrieval system