ID KHSE_BURXL Reviewed; 331 AA.
AC Q13RY4;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 01-MAY-2013, entry version 48.
DE RecName: Full=Homoserine kinase;
DE Short=HK;
DE Short=HSK;
DE EC=2.7.1.39;
GN Name=thrB; OrderedLocusNames=Bxeno_B0187; ORFNames=Bxe_B2840;
OS Burkholderia xenovorans (strain LB400).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia.
OX NCBI_TaxID=266265;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LB400;
RX PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA Tiedje J.M.;
RT "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT genome shaped for versatility.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC -!- CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-
CC homoserine.
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC threonine from L-aspartate: step 4/5.
CC -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family.
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DR EMBL; CP000271; ABE33155.1; -; Genomic_DNA.
DR RefSeq; YP_552505.1; NC_007952.1.
DR ProteinModelPortal; Q13RY4; -.
DR STRING; 266265.Bxe_B2840; -.
DR EnsemblBacteria; ABE33155; ABE33155; Bxe_B2840.
DR GeneID; 4006561; -.
DR KEGG; bxe:Bxe_B2840; -.
DR PATRIC; 19335156; VBIBurXen52548_4853.
DR eggNOG; COG2334; -.
DR HOGENOM; HOG000004810; -.
DR KO; K02204; -.
DR OMA; PDNVFFL; -.
DR ProtClustDB; PRK05231; -.
DR BioCyc; BXEN266265:GJII-4797-MONOMER; -.
DR UniPathway; UPA00050; UER00064.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004413; F:homoserine kinase activity; IEA:HAMAP.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00301; Homoser_kinase_2; 1; -.
DR InterPro; IPR002575; Aminoglycoside_PTrfase.
DR InterPro; IPR005280; Homoserine_kinase_ThrB.
DR InterPro; IPR011009; Kinase-like_dom.
DR Pfam; PF01636; APH; 1.
DR SUPFAM; SSF56112; Kinase_like; 1.
DR TIGRFAMs; TIGR00938; thrB_alt; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; ATP-binding; Complete proteome; Kinase;
KW Nucleotide-binding; Threonine biosynthesis; Transferase.
FT CHAIN 1 331 Homoserine kinase.
FT /FTId=PRO_0000300791.
SQ SEQUENCE 331 AA; 37328 MW; 48C1A92E324F2777 CRC64;
MAVFTAVTEP QLAEWMRHYD LGDVVEFRGI SSGIENSNFF LTTTRGEYVL TIFEKLTAEQ
LPFYLDLMRH LAAHRVPVPD PMPREDGALF GLLQGKPAAI VTRLEGAPEL APGVEHCIEV
GQMLARMHLA GRDYPAYQPN LRSLPWWKET VPTILPFLEG GQRELLSSEL AYQEAFFASA
DYAALPEGPC HADLFRDNAM FAHAEPGTGH EVRLGGFFDF YFAGCDKWLF DVAVTVNDWC
VDLATGKLDA ARTEAMLRAY QTVRPFTAEE NRHWGDMLRA GAYRFWVSRL YDFHLPRAAE
LLKPHDPGHF ERILRERLSG VALPGIHTSC N
//
