ID KHSE_SCHPO Reviewed; 338 AA.
AC O43056;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-APR-2013, entry version 96.
DE RecName: Full=Probable homoserine kinase;
DE Short=HK;
DE Short=HSK;
DE EC=2.7.1.39;
GN ORFNames=SPBC4C3.03;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales;
OC Schizosaccharomycetaceae; Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-
CC homoserine.
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC threonine from L-aspartate: step 4/5.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SIMILARITY: Belongs to the GHMP kinase family. Homoserine kinase
CC subfamily.
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DR EMBL; CU329671; CAA16824.1; -; Genomic_DNA.
DR PIR; T40495; T40495.
DR RefSeq; NP_596303.1; NM_001022224.2.
DR ProteinModelPortal; O43056; -.
DR STRING; 4896.SPBC4C3.03-1; -.
DR PaxDb; O43056; -.
DR EnsemblFungi; SPBC4C3.03.1; SPBC4C3.03.1:pep; SPBC4C3.03.
DR GeneID; 2540857; -.
DR KEGG; spo:SPBC4C3.03; -.
DR PomBase; SPBC4C3.03; -.
DR eggNOG; COG0083; -.
DR HOGENOM; HOG000247199; -.
DR KO; K00872; -.
DR OMA; LHEPYRW; -.
DR OrthoDB; EOG4B8NNT; -.
DR UniPathway; UPA00050; UER00064.
DR NextBio; 20801973; -.
DR GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004413; F:homoserine kinase activity; ISS:PomBase.
DR GO; GO:0006555; P:methionine metabolic process; ISS:PomBase.
DR GO; GO:0009088; P:threonine biosynthetic process; ISS:PomBase.
DR Gene3D; 3.30.230.10; -; 1.
DR InterPro; IPR006204; GHMP_kinase_N_dom.
DR InterPro; IPR006203; GHMP_knse_ATP-bd_CS.
DR InterPro; IPR000870; Homoserine_kinase.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR Pfam; PF00288; GHMP_kinases_N; 1.
DR PIRSF; PIRSF000676; Homoser_kin; 1.
DR PRINTS; PR00958; HOMSERKINASE.
DR SUPFAM; SSF54211; Ribosomal_S5_D2-typ_fold; 1.
DR TIGRFAMs; TIGR00191; thrB; 1.
DR PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; ATP-binding; Complete proteome; Kinase;
KW Nucleotide-binding; Reference proteome; Threonine biosynthesis;
KW Transferase.
FT CHAIN 1 338 Probable homoserine kinase.
FT /FTId=PRO_0000156655.
FT NP_BIND 93 103 ATP (Potential).
SQ SEQUENCE 338 AA; 36608 MW; 17B4F94188F6267B CRC64;
MQKFQIKVPA SSANIGPGFD VLGMSLEEYM TLDVEVSTES GPCVLTYEGD GKEHVSLDVQ
KNMITQTSLY VLRCNNISTF PYATKIHVIN PIPLGRGMGS SGSAAIAGVM LANEIAKLGL
SKLQMMDYVL MIERHPDNVM ASMMGGFVGS FLRELSEEEK NAFSPSADDL LKNEALTLPP
KSLGTFARLP WASELKAIVV IPEFHLATSK ARSVLPTSYG RTDVVYNLQR LALLTTALGQ
TPINPHLVYE VMKDKVHQPY RASLIPGLQN ILATLNPDTQ PGLCGICLSG AGPTVLALAT
GNFDEIAHAM LSIFEKHGVK CRYLVLSPAF DGATVKYF
//
