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Database: UniProt/SWISS-PROT
Entry: KITH_MYCGA
LinkDB: KITH_MYCGA
Original site: KITH_MYCGA 
ID   KITH_MYCGA              Reviewed;         224 AA.
AC   Q8RLE0;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   15-AUG-2003, sequence version 2.
DT   28-FEB-2018, entry version 90.
DE   RecName: Full=Thymidine kinase {ECO:0000255|HAMAP-Rule:MF_00124};
DE            EC=2.7.1.21 {ECO:0000255|HAMAP-Rule:MF_00124};
GN   Name=tdk {ECO:0000255|HAMAP-Rule:MF_00124};
GN   OrderedLocusNames=MYCGA6630; ORFNames=MGA_0502;
OS   Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2)).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=710127;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A5969Var.B;
RA   Skamrov A.V., Gol'dman M.A., Feoktistova E.S., Bibilashvili R.S.;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R(low / passage 15 / clone 2);
RX   PubMed=12949158; DOI=10.1099/mic.0.26427-0;
RA   Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F.,
RA   Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J.;
RT   "The complete genome sequence of the avian pathogen Mycoplasma
RT   gallisepticum strain R(low).";
RL   Microbiology 149:2307-2316(2003).
CC   -!- CATALYTIC ACTIVITY: ATP + thymidine = ADP + thymidine 5'-
CC       phosphate. {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00124}.
DR   EMBL; AY081866; AAL91131.1; -; Genomic_DNA.
DR   EMBL; AE015450; AAP57013.2; -; Genomic_DNA.
DR   RefSeq; WP_011113924.1; NC_004829.2.
DR   ProteinModelPortal; Q8RLE0; -.
DR   SMR; Q8RLE0; -.
DR   PRIDE; Q8RLE0; -.
DR   EnsemblBacteria; AAP57013; AAP57013; MGA_0502.
DR   GeneID; 1089922; -.
DR   KEGG; mga:MGA_0502; -.
DR   HOGENOM; HOG000076390; -.
DR   KO; K00857; -.
DR   OMA; KEQFGWI; -.
DR   Proteomes; UP000001418; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00124; Thymidine_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   InterPro; IPR020633; Thymidine_kinase_CS.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA synthesis; Kinase;
KW   Metal-binding; Nucleotide-binding; Reference proteome; Transferase;
KW   Zinc.
FT   CHAIN         1    224       Thymidine kinase.
FT                                /FTId=PRO_0000174993.
FT   NP_BIND      19     26       ATP. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   NP_BIND      93     96       ATP. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   ACT_SITE     94     94       Proton acceptor. {ECO:0000255|HAMAP-
FT                                Rule:MF_00124}.
FT   METAL       150    150       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   METAL       153    153       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   METAL       188    188       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   METAL       191    191       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   CONFLICT     10     10       T -> S (in Ref. 1; AAL91131).
FT                                {ECO:0000305}.
SQ   SEQUENCE   224 AA;  25259 MW;  8674C04BE5741FCC CRC64;
     MAKKNAMTTT NGWIEAICGP MFAGKTDELI RKIKRYEYAD VKSLVFSPAT DTRSAQEIIN
     SRDGRRIGSI KIKKAFEIYD YVLLHKPQLV GIDEVQFFDD SIVEVIQTLA DNQINVIVAG
     LDRDFRGEPF GPIPKILGIA ESVIRLTAIC SECGAEASRS QRLIDNQPAD YNCETILIGD
     TESYAPRCRH HHKVPNRPIN DQTKNFKRAL KNNFDKIVEQ SSKD
//
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