ID KYNB_BURXL Reviewed; 212 AA.
AC Q13UP0;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 01-MAY-2013, entry version 36.
DE RecName: Full=Kynurenine formamidase;
DE Short=KFA;
DE Short=KFase;
DE EC=3.5.1.9;
DE AltName: Full=Arylformamidase;
DE AltName: Full=N-formylkynurenine formamidase;
DE Short=FKF;
GN Name=kynB; OrderedLocusNames=Bxeno_A3661; ORFNames=Bxe_A0735;
OS Burkholderia xenovorans (strain LB400).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia.
OX NCBI_TaxID=266265;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LB400;
RX PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA Tiedje J.M.;
RT "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT genome shaped for versatility.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC -!- FUNCTION: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-
CC kynurenine, the second step in the kynurenine pathway of
CC tryptophan degradation (By similarity).
CC -!- CATALYTIC ACTIVITY: N-formyl-L-kynurenine + H(2)O = formate + L-
CC kynurenine.
CC -!- PATHWAY: Amino-acid degradation; L-tryptophan degradation via
CC kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
CC -!- SIMILARITY: Belongs to the KynB family.
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DR EMBL; CP000270; ABE32199.1; -; Genomic_DNA.
DR RefSeq; YP_560251.1; NC_007951.1.
DR ProteinModelPortal; Q13UP0; -.
DR STRING; 266265.Bxe_A0735; -.
DR EnsemblBacteria; ABE32199; ABE32199; Bxe_A0735.
DR GeneID; 4005675; -.
DR KEGG; bxe:Bxe_A0735; -.
DR PATRIC; 19333129; VBIBurXen52548_3859.
DR eggNOG; COG1878; -.
DR HOGENOM; HOG000219455; -.
DR KO; K07130; -.
DR OMA; HTSKWPL; -.
DR ProtClustDB; CLSK930430; -.
DR BioCyc; BXEN266265:GJII-3814-MONOMER; -.
DR UniPathway; UPA00333; UER00454.
DR GO; GO:0004061; F:arylformamidase activity; ISS:UniProtKB.
DR GO; GO:0004328; F:formamidase activity; IEA:InterPro.
DR GO; GO:0043420; P:anthranilate metabolic process; ISS:UniProtKB.
DR GO; GO:0019441; P:tryptophan catabolic process to kynurenine; ISS:UniProtKB.
DR HAMAP; MF_01969; KynB; 1; -.
DR InterPro; IPR017484; Arylformamidase.
DR InterPro; IPR007325; Cyclase.
DR Pfam; PF04199; Cyclase; 1.
DR TIGRFAMs; TIGR03035; trp_arylform; 1.
PE 3: Inferred from homology;
KW Complete proteome; Hydrolase; Tryptophan catabolism.
FT CHAIN 1 212 Kynurenine formamidase.
FT /FTId=PRO_0000362119.
SQ SEQUENCE 212 AA; 22887 MW; 8EB926EC71A801C8 CRC64;
MRTLWDITPA VDTATPVWPG DTPVGIERVW RMEAGSPVNV ARLTLSPHTG AHTDAPLHYD
AEGAAIGDVP LDAYLGRCRV IHCIGASPVV TPQHLTGSLD DLPPRVLLRT YRNAPTNVWD
SAFCAVAPDT IDLLASRGVK LIGIDTPSLD PQESKTMDAH HRIRAHRMAI LEGIVLDEVA
AGDYELIALP LKLTTLDASP VRAILRALPE SH
//
