ID LPXA_BURM1 Reviewed; 262 AA.
AC A9AIM6;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 01-MAY-2013, entry version 42.
DE RecName: Full=Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase;
DE Short=UDP-N-acetylglucosamine acyltransferase;
DE EC=2.3.1.129;
GN Name=lpxA; OrderedLocusNames=Bmul_1269, BMULJ_01978;
OS Burkholderia multivorans (strain ATCC 17616 / 249).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=395019;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17616 / 249;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M.,
RA Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Kim E., Tiedje J., Richardson P.;
RT "Complete sequence of chromosome 1 of Burkholderia multivorans ATCC
RT 17616.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17616 / 249;
RA Ohtsubo Y., Yamashita A., Kurokawa K., Takami H., Yuhara S.,
RA Nishiyama E., Endo R., Miyazaki R., Ono A., Yano K., Ito M., Sota M.,
RA Yuji N., Hattori M., Tsuda M.;
RT "Complete genome sequence of Burkholderia multivorans ATCC 17616.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the biosynthesis of lipid A, a
CC phosphorylated glycolipid that anchors the lipopolysaccharide to
CC the outer membrane of the cell (By similarity).
CC -!- CATALYTIC ACTIVITY: (R)-3-hydroxytetradecanoyl-[acyl-carrier-
CC protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-
CC protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-
CC glucosamine.
CC -!- PATHWAY: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid
CC IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and
CC UDP-N-acetyl-alpha-D-glucosamine: step 1/6.
CC -!- SUBUNIT: Homotrimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC LpxA subfamily.
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DR EMBL; CP000868; ABX14957.1; -; Genomic_DNA.
DR EMBL; AP009385; BAG43895.1; -; Genomic_DNA.
DR RefSeq; YP_001579454.1; NC_010084.1.
DR RefSeq; YP_001946431.1; NC_010804.1.
DR ProteinModelPortal; A9AIM6; -.
DR SMR; A9AIM6; 2-262.
DR STRING; 395019.Bmul_1269; -.
DR EnsemblBacteria; ABX14957; ABX14957; Bmul_1269.
DR EnsemblBacteria; BAG43895; BAG43895; BMULJ_01978.
DR GeneID; 5766911; -.
DR GeneID; 6359656; -.
DR KEGG; bmj:BMULJ_01978; -.
DR KEGG; bmu:Bmul_1269; -.
DR PATRIC; 19165787; VBIBurMul203716_2966.
DR eggNOG; COG1043; -.
DR HOGENOM; HOG000294326; -.
DR KO; K00677; -.
DR OMA; REFCTFN; -.
DR ProtClustDB; PRK05289; -.
DR BioCyc; BMUL395019:GIYO-1976-MONOMER; -.
DR UniPathway; UPA00359; UER00477.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008780; F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity; IEA:HAMAP.
DR GO; GO:0009245; P:lipid A biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00387; LpxA; 1; -.
DR InterPro; IPR001451; Hexapep_transf.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR010137; Lipid_A_LpxA.
DR InterPro; IPR011004; Trimer_LpxA-like.
DR Pfam; PF00132; Hexapep; 4.
DR PIRSF; PIRSF000456; UDP-GlcNAc_acltr; 1.
DR SUPFAM; SSF51161; Trimer_LpxA_like; 1.
DR TIGRFAMs; TIGR01852; lipid_A_lpxA; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Complete proteome; Cytoplasm; Lipid A biosynthesis;
KW Lipid biosynthesis; Lipid metabolism; Repeat; Transferase.
FT CHAIN 1 262 Acyl-[acyl-carrier-protein]--UDP-N-
FT acetylglucosamine O-acyltransferase.
FT /FTId=PRO_1000122690.
SQ SEQUENCE 262 AA; 27873 MW; C90BBC7EC37994F5 CRC64;
MTRIHPTAIV EPGAQIDESV EIGPYAIIGP HVTIGARTTI GSHSVIEGHT TIGEDNRIGH
YASVGGRPQD MKYKDEPTKL VIGNRNTIRE FTTIHTGTVQ DAGVTTLGDD NWIMAYVHIG
HDCRVGNHVI LSSNAQMAGH VEIGDWAIIG GMSGVHQFVR IGAHAMLGGA SALVQDVPPF
VIAAGNKAEP HGINVEGLRR RGFSPDAISA LRSAYRLLYK NGLSLEEAKT QLRELAQAGG
DGDAPVNALV AFIDASQRGI IR
//
