ID LSM6_COPC7 Reviewed; 95 AA.
AC A8NHT8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 01-MAY-2013, entry version 28.
DE RecName: Full=U6 snRNA-associated Sm-like protein LSm6;
GN Name=LSM6; ORFNames=CC1G_01502;
OS Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC
OS 9003) (Inky cap fungus) (Hormographiella aspergillata).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC Agaricomycetes; Agaricomycetidae; Agaricales; Psathyrellaceae;
OC Coprinopsis.
OX NCBI_TaxID=240176;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003;
RX PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W.,
RA Borodovsky M., Burns C., Canbaeck B., Casselton L.A., Cheng C.K.,
RA Deng J., Dietrich F.S., Fargo D.C., Farman M.L., Gathman A.C.,
RA Goldberg J., Guigo R., Hoegger P.J., Hooker J.B., Huggins A.,
RA James T.Y., Kamada T., Kilaru S., Kodira C., Kuees U., Kupfer D.,
RA Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.-J., Mackey A.J.,
RA Manning G., Martin F., Muraguchi H., Natvig D.O., Palmerini H.,
RA Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA Zolan M.E., Pukkila P.J.;
RT "Insights into evolution of multicellular fungi from the assembled
RT chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC -!- FUNCTION: Component of LSm protein complexes, which are involved
CC in RNA processing and may function in a chaperone-like manner,
CC facilitating the efficient association of RNA processing factors
CC with their substrates. Component of the cytoplasmic LSM1-LSM7
CC complex, which is thought to be involved in mRNA degradation by
CC activating the decapping step in the 5'-to-3' mRNA decay pathway.
CC Component of the nuclear LSM2-LSM8 complex, which is involved in
CC splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple
CC snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP,
CC spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds
CC directly to the 3'-terminal U-tract of U6 snRNA and plays a role
CC in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP
CC complexes. LSM2-LSM8 probably also is involved degradation of
CC nuclear pre-mRNA by targeting them for decapping, and in
CC processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
CC -!- SUBUNIT: Component of the heptameric LSM1-LSM7 complex, which
CC consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component
CC of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3,
CC LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-
CC membered ring structure with a doughnut shape (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC similarity).
CC -!- SIMILARITY: Belongs to the snRNP Sm proteins family. SmF/LSm6
CC subfamily.
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DR EMBL; AACS02000010; EAU87855.2; -; Genomic_DNA.
DR RefSeq; XP_001833825.2; XM_001833773.2.
DR ProteinModelPortal; A8NHT8; -.
DR GeneID; 6010327; -.
DR KEGG; cci:CC1G_01502; -.
DR KO; K12625; -.
DR OrthoDB; EOG4CC7B6; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR010920; LSM_dom.
DR InterPro; IPR001163; Ribonucl_LSM.
DR InterPro; IPR006649; Ribonucl_LSM_euk/arc.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; Sm_like_riboprot; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Ribonucleoprotein; RNA-binding; rRNA processing;
KW Spliceosome; tRNA processing.
FT CHAIN 1 95 U6 snRNA-associated Sm-like protein LSm6.
FT /FTId=PRO_0000333594.
SQ SEQUENCE 95 AA; 10189 MW; 77C061CAD3592F56 CRC64;
MADSPSPAPQ PPQPPAPTTH TGSPTDFLKG VVGKRVVVRL LSGVDYRGIL SCLDGYMNIA
MEQTEESVNG KVVNRYGDAF IRGNNVLYIS ADEPI
//
