ID MAAI_CAEEL Reviewed; 214 AA.
AC Q18938;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 01-MAY-2013, entry version 110.
DE RecName: Full=Probable maleylacetoacetate isomerase;
DE Short=MAAI;
DE EC=5.2.1.2;
DE AltName: Full=Glutathione S-transferase gst-42;
GN Name=gst-42; ORFNames=D1053.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for
RT investigating biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY: 4-maleylacetoacetate = 4-fumarylacetoacetate.
CC -!- COFACTOR: Glutathione (By similarity).
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 5/6.
CC -!- INTERACTION:
CC Self; NbExp=3; IntAct=EBI-318532, EBI-318532;
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the GST superfamily. Zeta family.
CC -!- SIMILARITY: Contains 1 GST C-terminal domain.
CC -!- SIMILARITY: Contains 1 GST N-terminal domain.
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DR EMBL; Z66560; CAA91449.1; -; Genomic_DNA.
DR PIR; T20294; T20294.
DR RefSeq; NP_509962.1; NM_077561.6.
DR ProteinModelPortal; Q18938; -.
DR SMR; Q18938; 5-210.
DR DIP; DIP-24905N; -.
DR IntAct; Q18938; 3.
DR MINT; MINT-1068751; -.
DR STRING; 6239.D1053.1; -.
DR PaxDb; Q18938; -.
DR EnsemblMetazoa; D1053.1; D1053.1; D1053.1.
DR GeneID; 183911; -.
DR KEGG; cel:CELE_D1053.1; -.
DR UCSC; D1053.1; c. elegans.
DR CTD; 183911; -.
DR WormBase; D1053.1; CE03099; WBGene00001790; gst-42.
DR eggNOG; COG0625; -.
DR GeneTree; ENSGT00390000006580; -.
DR HOGENOM; HOG000125758; -.
DR InParanoid; Q18938; -.
DR KO; K01800; -.
DR OMA; RAQVRMI; -.
DR UniPathway; UPA00139; UER00340.
DR NextBio; 922820; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016034; F:maleylacetoacetate isomerase activity; IEA:EC.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; -; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
DR InterPro; IPR005955; Mal_ac_isom.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR SUPFAM; SSF47616; GST_C_like; 1.
DR SUPFAM; SSF52833; Thiordxn-like_fd; 1.
DR TIGRFAMs; TIGR01262; maiA; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Cytoplasm; Isomerase; Phenylalanine catabolism;
KW Reference proteome; Tyrosine catabolism.
FT CHAIN 1 214 Probable maleylacetoacetate isomerase.
FT /FTId=PRO_0000186025.
FT DOMAIN 4 84 GST N-terminal.
FT DOMAIN 89 212 GST C-terminal.
FT REGION 14 19 Glutathione binding (By similarity).
FT REGION 68 69 Glutathione binding (By similarity).
FT REGION 112 114 Glutathione binding (By similarity).
FT BINDING 56 56 Glutathione; via amide nitrogen and
FT carbonyl oxygen (By similarity).
FT BINDING 108 108 Glutathione (By similarity).
SQ SEQUENCE 214 AA; 23656 MW; EF1CB1EE62EF41EB CRC64;
MSNQKPVLYS YWRSSCSWRV RIALALKNVD YEYKTVDLLS EEAKSKLKEI NPAAKVPTFV
VDGQVITESL AIIEYLEETH PDVPLLPKDP IKRAHARAIS LLVASGIQPL HNLKVLQLLN
KKEAGFGGQF AKQFVVEGLT ALEILLKQHS GKYAVGDDVT IADLSIPPLI YSANRFNLDL
SPYPTVNRIN ETLADIPAFI AAHPDNQPDT GLNA
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