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Database: UniProt/SWISS-PROT
Entry: MAAI_CAEEL
LinkDB: MAAI_CAEEL
Original site: MAAI_CAEEL 
ID   MAAI_CAEEL              Reviewed;         214 AA.
AC   Q18938;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   29-OCT-2014, entry version 121.
DE   RecName: Full=Probable maleylacetoacetate isomerase;
DE            Short=MAAI;
DE            EC=5.2.1.2;
DE   AltName: Full=Glutathione S-transferase gst-42;
GN   Name=gst-42; ORFNames=D1053.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY: 4-maleylacetoacetate = 4-fumarylacetoacetate.
CC   -!- COFACTOR: Glutathione. {ECO:0000250}.
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetate and fumarate from L-phenylalanine: step 5/6.
CC   -!- INTERACTION:
CC       Self; NbExp=3; IntAct=EBI-318532, EBI-318532;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GST superfamily. Zeta family.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 GST C-terminal domain. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 GST N-terminal domain. {ECO:0000305}.
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DR   EMBL; Z66560; CAA91449.1; -; Genomic_DNA.
DR   PIR; T20294; T20294.
DR   RefSeq; NP_509962.1; NM_077561.6.
DR   UniGene; Cel.11101; -.
DR   ProteinModelPortal; Q18938; -.
DR   SMR; Q18938; 5-210.
DR   BioGrid; 48718; 3.
DR   DIP; DIP-24905N; -.
DR   IntAct; Q18938; 3.
DR   MINT; MINT-1068751; -.
DR   STRING; 6239.D1053.1; -.
DR   PaxDb; Q18938; -.
DR   PRIDE; Q18938; -.
DR   EnsemblMetazoa; D1053.1; D1053.1; WBGene00001790.
DR   GeneID; 183911; -.
DR   KEGG; cel:CELE_D1053.1; -.
DR   UCSC; D1053.1; c. elegans.
DR   CTD; 183911; -.
DR   WormBase; D1053.1; CE03099; WBGene00001790; gst-42.
DR   eggNOG; COG0625; -.
DR   GeneTree; ENSGT00390000006580; -.
DR   HOGENOM; HOG000125758; -.
DR   InParanoid; Q18938; -.
DR   KO; K01800; -.
DR   OMA; RAQVRMI; -.
DR   OrthoDB; EOG7TF79P; -.
DR   PhylomeDB; Q18938; -.
DR   UniPathway; UPA00139; UER00340.
DR   NextBio; 922820; -.
DR   PRO; PR:Q18938; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0016034; F:maleylacetoacetate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1050.10; -; 1.
DR   Gene3D; 3.40.30.10; -; 1.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR005955; Mal_ac_isom.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   Pfam; PF13417; GST_N_3; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR01262; maiA; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasm; Isomerase; Phenylalanine catabolism;
KW   Reference proteome; Tyrosine catabolism.
FT   CHAIN         1    214       Probable maleylacetoacetate isomerase.
FT                                /FTId=PRO_0000186025.
FT   DOMAIN        4     84       GST N-terminal.
FT   DOMAIN       89    212       GST C-terminal.
FT   REGION       14     19       Glutathione binding. {ECO:0000250}.
FT   REGION       68     69       Glutathione binding. {ECO:0000250}.
FT   REGION      112    114       Glutathione binding. {ECO:0000250}.
FT   BINDING      56     56       Glutathione; via amide nitrogen and
FT                                carbonyl oxygen. {ECO:0000250}.
FT   BINDING     108    108       Glutathione. {ECO:0000250}.
SQ   SEQUENCE   214 AA;  23656 MW;  EF1CB1EE62EF41EB CRC64;
     MSNQKPVLYS YWRSSCSWRV RIALALKNVD YEYKTVDLLS EEAKSKLKEI NPAAKVPTFV
     VDGQVITESL AIIEYLEETH PDVPLLPKDP IKRAHARAIS LLVASGIQPL HNLKVLQLLN
     KKEAGFGGQF AKQFVVEGLT ALEILLKQHS GKYAVGDDVT IADLSIPPLI YSANRFNLDL
     SPYPTVNRIN ETLADIPAFI AAHPDNQPDT GLNA
//
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