ID MDH_MYCA1 Reviewed; 329 AA.
AC A0QCI6;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 29-MAY-2013, entry version 47.
DE RecName: Full=Malate dehydrogenase;
DE EC=1.1.1.37;
GN Name=mdh; OrderedLocusNames=MAV_1380;
OS Mycobacterium avium (strain 104).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC Mycobacterium avium complex (MAC).
OX NCBI_TaxID=243243;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=104;
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reversible oxidation of malate to
CC oxaloacetate (By similarity).
CC -!- CATALYTIC ACTIVITY: (S)-malate + NAD(+) = oxaloacetate + NADH.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
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DR EMBL; CP000479; ABK67674.1; -; Genomic_DNA.
DR RefSeq; YP_880624.1; NC_008595.1.
DR ProteinModelPortal; A0QCI6; -.
DR SMR; A0QCI6; 4-329.
DR STRING; 243243.MAV_1380; -.
DR EnsemblBacteria; ABK67674; ABK67674; MAV_1380.
DR GeneID; 4526786; -.
DR KEGG; mav:MAV_1380; -.
DR PATRIC; 17984503; VBIMycAvi38287_1353.
DR eggNOG; COG0039; -.
DR HOGENOM; HOG000220953; -.
DR KO; K00024; -.
DR OMA; AINDHAA; -.
DR ProtClustDB; PRK05442; -.
DR BioCyc; MAVI243243:GH3Y-1380-MONOMER; -.
DR GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:HAMAP.
DR GO; GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:HAMAP.
DR Gene3D; 3.40.50.720; -; 1.
DR Gene3D; 3.90.110.10; -; 1.
DR HAMAP; MF_01517; Malate_dehydrog_2; 1; -.
DR InterPro; IPR001557; L-lactate/malate_DH.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR001252; Malate_DH_AS.
DR InterPro; IPR010945; Malate_DH_type2.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR PANTHER; PTHR23382; PTHR23382; 1.
DR Pfam; PF02866; Ldh_1_C; 1.
DR Pfam; PF00056; Ldh_1_N; 1.
DR PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR SUPFAM; SSF56327; Lactate_DH/Glyco_hydro_4_C; 1.
DR TIGRFAMs; TIGR01759; MalateDH-SF1; 1.
DR PROSITE; PS00068; MDH; 1.
PE 3: Inferred from homology;
KW Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
FT CHAIN 1 329 Malate dehydrogenase.
FT /FTId=PRO_0000294392.
FT NP_BIND 12 18 NAD (By similarity).
FT NP_BIND 130 132 NAD (By similarity).
FT ACT_SITE 188 188 Proton acceptor (By similarity).
FT BINDING 93 93 Substrate (By similarity).
FT BINDING 99 99 Substrate (By similarity).
FT BINDING 106 106 NAD (By similarity).
FT BINDING 113 113 NAD (By similarity).
FT BINDING 132 132 Substrate (By similarity).
FT BINDING 163 163 Substrate (By similarity).
SQ SEQUENCE 329 AA; 34604 MW; A7AF7641254040AD CRC64;
MSASPLKVAV TGAAGQIGYS LLFRLASGSL LGPDRPIELR LLEIEPALKA LEGVVMELDD
CAFPLLSGVE IGADPNKIFD GANLALLVGA RPRGPGMERS DLLEANGAIF TAQGKALNEV
AADDIRVGVT GNPANTNALI AMSNAPDIPR ERFSALTRLD HNRAISQLAK KTGAKVTDIT
KMTIWGNHSA TQYPDIFHAE VKGKNAAEVV GDQNWIENDF IPTVAKRGAA IIDARGASSA
ASAASATTDA ARDWLLGTPA GDWVSMAVIS DGSYGVPEGL ISSFPVTTKD GDWTIVQGLE
IDEFSRSRID KTTAELADER NAVTQLGLI
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