ID METE_SULSO Reviewed; 332 AA.
AC Q980A9;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 01-MAY-2013, entry version 64.
DE RecName: Full=Probable methylcobalamin:homocysteine methyltransferase;
DE EC=2.1.1.-;
DE AltName: Full=Methionine synthase;
GN Name=metE; OrderedLocusNames=SSO0407;
OS Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 /
OS P2).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=273057;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX PubMed=11427726; DOI=10.1073/pnas.141222098;
RA She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G.,
RA Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A.,
RA De Moors A., Erauso G., Fletcher C., Gordon P.M.K.,
RA Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X.,
RA Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N.,
RA Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
CC -!- FUNCTION: Catalyzes the transfer of a methyl group from
CC methylcobalamin and methylcobinamide to homocysteine resulting in
CC methionine formation (By similarity).
CC -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC novo pathway.
CC -!- SIMILARITY: Belongs to the vitamin-B12 independent methionine
CC synthase family.
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DR EMBL; AE006641; AAK40736.1; -; Genomic_DNA.
DR PIR; A99185; A99185.
DR RefSeq; NP_341946.1; NC_002754.1.
DR ProteinModelPortal; Q980A9; -.
DR STRING; 273057.SSO0407; -.
DR PRIDE; Q980A9; -.
DR EnsemblBacteria; AAK40736; AAK40736; SSO0407.
DR GeneID; 1455546; -.
DR KEGG; sso:SSO0407; -.
DR eggNOG; COG0620; -.
DR HOGENOM; HOG000140559; -.
DR KO; K00549; -.
DR OMA; GINAKLM; -.
DR ProtClustDB; PRK04326; -.
DR UniPathway; UPA00051; -.
DR GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00288; MetE; 1; -.
DR InterPro; IPR022921; MetE_arc.
DR InterPro; IPR002629; Methionine_synth.
DR Pfam; PF01717; Meth_synt_2; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Complete proteome; Metal-binding;
KW Methionine biosynthesis; Methyltransferase; Reference proteome;
KW Transferase; Zinc.
FT CHAIN 1 332 Probable methylcobalamin:homocysteine
FT methyltransferase.
FT /FTId=PRO_0000098692.
FT METAL 211 211 Zinc (By similarity).
FT METAL 213 213 Zinc (By similarity).
FT METAL 296 296 Zinc (By similarity).
SQ SEQUENCE 332 AA; 38250 MW; 88D4CF48846B1C2B CRC64;
MSKLPLLPTT VIGSYPRPKW LRESIRLHKA GKMSNEDLQE AFNDAVIAVF QDHYKAGVDV
PTDGEVRRDE MVEFFAERIK GFKFYGPVRV WGTAYYRKPS VVSKIEYREP MLVDEFTFAK
SVSYTDNLKI TITGPYTIAE WSYNEYYRNK KDLVFDLAKA INQEIKNLVE AGAKIIQIDE
PALHTRKEDV SWGVEAVNEA VKGVNAKLVM HICYGDYSFV APYFNEIKVD QINFALKIYN
YKPLELLKKY GFDKELGAGV VDVHNRKVET SEEVANDIRK ILEYFPPEKV WINPDCGLKL
LSRKIAYQKL VSMVEGTKVV REELKRKGYS VD
//
