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Database: UniProt/SWISS-PROT
Entry: METE_SULSO
LinkDB: METE_SULSO
Original site: METE_SULSO 
ID   METE_SULSO              Reviewed;         332 AA.
AC   Q980A9;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-SEP-2014, entry version 71.
DE   RecName: Full=Methionine synthase;
DE            EC=2.1.1.-;
DE   AltName: Full=Homocysteine methyltransferase;
GN   Name=metE; OrderedLocusNames=SSO0407;
OS   Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 /
OS   P2).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G.,
RA   Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A.,
RA   De Moors A., Erauso G., Fletcher C., Gordon P.M.K.,
RA   Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X.,
RA   Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N.,
RA   Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
CC   -!- FUNCTION: Catalyzes the transfer of a methyl group to L-
CC       homocysteine resulting in methionine formation. The physiological
CC       methyl donor is unknown (By similarity).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway.
CC   -!- SIMILARITY: Belongs to the archaeal MetE family.
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DR   EMBL; AE006641; AAK40736.1; -; Genomic_DNA.
DR   PIR; A99185; A99185.
DR   RefSeq; NP_341946.1; NC_002754.1.
DR   ProteinModelPortal; Q980A9; -.
DR   STRING; 273057.SSO0407; -.
DR   PRIDE; Q980A9; -.
DR   EnsemblBacteria; AAK40736; AAK40736; SSO0407.
DR   GeneID; 1455546; -.
DR   KEGG; sso:SSO0407; -.
DR   eggNOG; COG0620; -.
DR   HOGENOM; HOG000140559; -.
DR   KO; K00549; -.
DR   OMA; RVWGNAY; -.
DR   BioCyc; SSOL273057:GCH2-393-MONOMER; -.
DR   UniPathway; UPA00051; -.
DR   GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00288; MetE; 1.
DR   InterPro; IPR002629; Met_Synth_C/arc.
DR   InterPro; IPR022921; MetE_arc.
DR   Pfam; PF01717; Meth_synt_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Metal-binding;
KW   Methionine biosynthesis; Methyltransferase; Reference proteome;
KW   Transferase; Zinc.
FT   CHAIN         1    332       Methionine synthase.
FT                                /FTId=PRO_0000098692.
FT   METAL       211    211       Zinc (By similarity).
FT   METAL       213    213       Zinc (By similarity).
FT   METAL       296    296       Zinc (By similarity).
SQ   SEQUENCE   332 AA;  38250 MW;  88D4CF48846B1C2B CRC64;
     MSKLPLLPTT VIGSYPRPKW LRESIRLHKA GKMSNEDLQE AFNDAVIAVF QDHYKAGVDV
     PTDGEVRRDE MVEFFAERIK GFKFYGPVRV WGTAYYRKPS VVSKIEYREP MLVDEFTFAK
     SVSYTDNLKI TITGPYTIAE WSYNEYYRNK KDLVFDLAKA INQEIKNLVE AGAKIIQIDE
     PALHTRKEDV SWGVEAVNEA VKGVNAKLVM HICYGDYSFV APYFNEIKVD QINFALKIYN
     YKPLELLKKY GFDKELGAGV VDVHNRKVET SEEVANDIRK ILEYFPPEKV WINPDCGLKL
     LSRKIAYQKL VSMVEGTKVV REELKRKGYS VD
//
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