ID METX_ALHEH Reviewed; 384 AA.
AC Q0ABU4;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 29-MAY-2013, entry version 51.
DE RecName: Full=Homoserine O-acetyltransferase;
DE EC=2.3.1.31;
DE AltName: Full=Homoserine O-trans-acetylase;
DE Short=HTA;
DE Short=Homoserine transacetylase;
GN Name=metX; OrderedLocusNames=Mlg_0338;
OS Alkalilimnicola ehrlichei (strain MLHE-1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC Ectothiorhodospiraceae; Alkalilimnicola.
OX NCBI_TaxID=187272;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MLHE-1;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P.,
RA Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T.,
RA King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T.,
RA Xie G., Stolz J.F., Richardson P.;
RT "Complete sequence of Alkalilimnicola ehrilichei MLHE-1.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-
CC homoserine.
CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. HTA family.
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DR EMBL; CP000453; ABI55693.1; -; Genomic_DNA.
DR RefSeq; YP_741183.1; NC_008340.1.
DR ProteinModelPortal; Q0ABU4; -.
DR STRING; 187272.Mlg_0338; -.
DR EnsemblBacteria; ABI55693; ABI55693; Mlg_0338.
DR GeneID; 4268326; -.
DR KEGG; aeh:Mlg_0338; -.
DR PATRIC; 20859848; VBIAlkEhr114327_0331.
DR eggNOG; COG2021; -.
DR HOGENOM; HOG000246301; -.
DR KO; K00641; -.
DR OMA; VSFTSDW; -.
DR ProtClustDB; PRK00175; -.
DR BioCyc; AEHR187272:GHAX-345-MONOMER; -.
DR UniPathway; UPA00051; UER00074.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004414; F:homoserine O-acetyltransferase activity; IEA:HAMAP.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00296; Homoser_O-acetyltr; 1; -.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR008220; Homoserine_AcTrfase.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PIRSF; PIRSF000443; Homoser_Ac_trans; 1.
DR TIGRFAMs; TIGR01392; homoserO_Ac_trn; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Amino-acid biosynthesis; Complete proteome;
KW Cytoplasm; Methionine biosynthesis; Transferase.
FT CHAIN 1 384 Homoserine O-acetyltransferase.
FT /FTId=PRO_1000115210.
FT ACT_SITE 157 157 Potential.
FT ACT_SITE 357 357 Potential.
SQ SEQUENCE 384 AA; 43094 MW; 6D85CE49C16400D4 CRC64;
MPKHLPADSV GIVEQHSLHF DEPLPLDCGR SLPAYDLVYE TYGELNAERS NAILICHALS
GSHHAAGYHS EEDRKPGWWE ACVGPGKPID TDRFYVVCCN NLGGCHGSTG PSSINPETHR
PYGPDFPLVT VRDWVHSQAR LADALGIERW AAVVGGSLGG MQAIQWAIDY PDRLGHVVAI
AVAPRLSAQN IGFNEVARQA ILTDPEFHGG RYYEHHTVPR RGLALARMLG HITYLSDDAM
RDKFGRDLRA DGGRYKFNFD VEFEVESYLR YQGRSFVDRF DANTYLLMTK VLDYFDPAAE
YDHDLSAALA HVQARFLLIS FSSDWRFPPE RSREIVRALE DNQKPISYLE VETSQGHDAF
LKPIPVYTEA FRAYMQGIAR EVGA
//
