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Database: UniProt/SWISS-PROT
Entry: MSR21_ORYSJ
LinkDB: MSR21_ORYSJ
Original site: MSR21_ORYSJ 
ID   MSR21_ORYSJ             Reviewed;         187 AA.
AC   Q7XUP7;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   29-OCT-2014, entry version 80.
DE   RecName: Full=Peptide methionine sulfoxide reductase A2-1;
DE            Short=OsMSRA2.1;
DE            EC=1.8.4.11;
DE   AltName: Full=Peptide-methionine (S)-S-oxide reductase;
DE            Short=Peptide Met(O) reductase;
DE   AltName: Full=Protein-methionine-S-oxide reductase;
GN   Name=MSRA2-1; OrderedLocusNames=Os04g0482000, LOC_Os04g40600;
GN   ORFNames=OsJ_15220, OSJNBb0011N17.16;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade;
OC   Ehrhartoideae; Oryzeae; Oryza.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447439; DOI=10.1038/nature01183;
RA   Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J.,
RA   Liu Y., Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y.,
RA   Weng Q., Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D.,
RA   Liu X., Lu T., Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J.,
RA   Wu M., Zhang R., Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H.,
RA   Cai Z., Ren S., Lv G., Gu W., Zhu G., Tu Y., Jia J., Zhang Y.,
RA   Chen J., Kang H., Chen X., Shao C., Sun Y., Hu Q., Zhang X., Zhang W.,
RA   Wang L., Ding C., Sheng H., Gu J., Chen S., Ni L., Zhu F., Chen W.,
RA   Lan L., Lai Y., Cheng Z., Gu M., Jiang J., Li J., Hong G., Xue Y.,
RA   Han B.;
RT   "Sequence and analysis of rice chromosome 4.";
RL   Nature 420:316-320(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H.,
RA   Cong L., Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J.,
RA   Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X.,
RA   Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y.,
RA   Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J.,
RA   Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y.,
RA   Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y.,
RA   Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z.,
RA   Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T.,
RA   Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H.,
RA   Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W.,
RA   Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L.,
RA   Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J.,
RA   Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=17031545; DOI=10.1007/s11120-006-9097-1;
RA   Rouhier N., Vieira Dos Santos C., Tarrago L., Rey P.;
RT   "Plant methionine sulfoxide reductase A and B multigenic families.";
RL   Photosyn. Res. 89:247-262(2006).
CC   -!- FUNCTION: Catalyzes the reduction of methionine sulfoxide (MetSO)
CC       to methionine in proteins. Plays a protective role against
CC       oxidative stress by restoring activity to proteins that have been
CC       inactivated by methionine oxidation. MSRA family specifically
CC       reduces the MetSO S-enantiomer (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide +
CC       H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CC   -!- CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H(2)O =
CC       L-methionine (S)-S-oxide + thioredoxin.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MsrA Met sulfoxide reductase family.
CC       {ECO:0000305}.
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DR   EMBL; AL606614; CAD41099.2; -; Genomic_DNA.
DR   EMBL; AP008210; BAF15030.1; -; Genomic_DNA.
DR   EMBL; CM000141; EAZ31123.1; -; Genomic_DNA.
DR   EMBL; AK064801; BAG89211.1; -; mRNA.
DR   RefSeq; NP_001053116.1; NM_001059651.1.
DR   UniGene; Os.75527; -.
DR   UniGene; Os.9958; -.
DR   ProteinModelPortal; Q7XUP7; -.
DR   EnsemblPlants; OS04T0482000-01; OS04T0482000-01; OS04G0482000.
DR   GeneID; 4336192; -.
DR   KEGG; osa:4336192; -.
DR   Gramene; Q7XUP7; -.
DR   eggNOG; COG0225; -.
DR   InParanoid; Q7XUP7; -.
DR   KO; K07304; -.
DR   OMA; AKHNPTT; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0008113; F:peptide-methionine (S)-S-oxide reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030091; P:protein repair; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   Gene3D; 3.30.1060.10; -; 1.
DR   HAMAP; MF_01401; MsrA; 1.
DR   InterPro; IPR028427; Met_Sox_Rdtase.
DR   InterPro; IPR002569; Met_Sox_Rdtase_MsrA.
DR   PANTHER; PTHR10173; PTHR10173; 1.
DR   Pfam; PF01625; PMSR; 1.
DR   SUPFAM; SSF55068; SSF55068; 1.
DR   TIGRFAMs; TIGR00401; msrA; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytoplasm; Oxidoreductase; Reference proteome.
FT   CHAIN         1    187       Peptide methionine sulfoxide reductase
FT                                A2-1.
FT                                /FTId=PRO_0000395515.
SQ   SEQUENCE   187 AA;  20807 MW;  3706EAF5A6196BED CRC64;
     MSDSNPGAAN PALGPDADAA AGEGLELAQF AAGCFWSVEL TYQRLPGVAR TEVGYSQGHR
     HEPTYRDVCG GGTGHAEVVR VHYDPKACPY EVLLDVFWAK HNPTTLNRQG NDVGTQYRSG
     IYYYTAEQEK AARDSLAEKQ KEWKERIVTE ILPATRFYPA EEYHQRYLEK GGQSAKKSCN
     DPIRCYG
//
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