ID MURA_SHEAM Reviewed; 418 AA.
AC A1SA71;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 01-MAY-2013, entry version 51.
DE RecName: Full=UDP-N-acetylglucosamine 1-carboxyvinyltransferase;
DE EC=2.5.1.7;
DE AltName: Full=Enoylpyruvate transferase;
DE AltName: Full=UDP-N-acetylglucosamine enolpyruvyl transferase;
DE Short=EPT;
GN Name=murA; OrderedLocusNames=Sama_3075;
OS Shewanella amazonensis (strain ATCC BAA-1098 / SB2B).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=326297;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1098 / SB2B;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R.,
RA Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Fredrickson J., Richardson P.;
RT "Complete sequence of Shewanella amazonensis SB2B.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cell wall formation. Adds enolpyruvyl to UDP-N-
CC acetylglucosamine (By similarity).
CC -!- CATALYTIC ACTIVITY: Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-
CC glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-
CC D-glucosamine.
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the EPSP synthase family. MurA subfamily.
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DR EMBL; CP000507; ABM01278.1; -; Genomic_DNA.
DR RefSeq; YP_928947.1; NC_008700.1.
DR ProteinModelPortal; A1SA71; -.
DR SMR; A1SA71; 1-418.
DR STRING; 326297.Sama_3075; -.
DR EnsemblBacteria; ABM01278; ABM01278; Sama_3075.
DR GeneID; 4605322; -.
DR KEGG; saz:Sama_3075; -.
DR PATRIC; 23455039; VBISheAma74963_3166.
DR eggNOG; COG0766; -.
DR HOGENOM; HOG000075602; -.
DR KO; K00790; -.
DR OMA; SIWALAP; -.
DR ProtClustDB; PRK09369; -.
DR BioCyc; SAMA326297:GH0T-3205-MONOMER; -.
DR UniPathway; UPA00219; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008760; F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity; IEA:HAMAP.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:HAMAP.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR GO; GO:0019277; P:UDP-N-acetylgalactosamine biosynthetic process; IEA:InterPro.
DR Gene3D; 3.65.10.10; -; 2.
DR HAMAP; MF_00111; MurA; 1; -.
DR InterPro; IPR001986; Enolpyruvate_Tfrase_dom.
DR InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR InterPro; IPR005750; UDP_GlcNAc_COvinyl_MurA.
DR PANTHER; PTHR21090:SF4; PTHR21090:SF4; 1.
DR Pfam; PF00275; EPSP_synthase; 1.
DR SUPFAM; SSF55205; RNA3'_cycl/enolpyr_transf_A/B; 1.
DR TIGRFAMs; TIGR01072; murA; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell shape;
KW Cell wall biogenesis/degradation; Complete proteome; Cytoplasm;
KW Peptidoglycan synthesis; Transferase.
FT CHAIN 1 418 UDP-N-acetylglucosamine 1-
FT carboxyvinyltransferase.
FT /FTId=PRO_1000023097.
FT ACT_SITE 116 116 Proton donor (By similarity).
FT MOD_RES 116 116 2-(S-cysteinyl)pyruvic acid O-
FT phosphothioketal (By similarity).
SQ SEQUENCE 418 AA; 44577 MW; 62325B6022B337CD CRC64;
MDKLSIQSGG PLAGTVVISG AKNAALPILM AGVLAESPFV LTNVPSLRDV DTSCKLLRCL
GAEVTQDGDR ITIDSSRIDH FVAPYELVKT MRASILILGP LLARFGTADV SLPGGCAIGA
RPVNLHLHGL EQMGAKIEVK EGYIKARVDG RLKGAHIFMD MVSVGATENL LMAAALADGV
TVIENAAREP EVIDLANCLV AMGAQISGIG TATLKITGVE RLNGCDYRVM PDRIETGTFL
VAAAVTRGRI RCENADPSSL ESVLAKLEDA GAEINTGDDW IELDMHGKRP KAVNIKTAPY
PAFPTDMQAQ FCVLNCLAEG TGTITETIFE NRFMHVPELM RMGANMELEG HTCIVHGVER
LSGAQVMATD LRASASLVIA GLMADGTTLV DRIYHLDRGY EHIETKFEGL GGKVVRVK
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