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Database: UniProt/SWISS-PROT
Entry: NIFD_METMP
LinkDB: NIFD_METMP
Original site: NIFD_METMP 
ID   NIFD_METMP              Reviewed;         477 AA.
AC   P0CW51; P71526;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   14-MAY-2014, entry version 17.
DE   RecName: Full=Nitrogenase molybdenum-iron protein alpha chain;
DE            EC=1.18.6.1;
DE   AltName: Full=Dinitrogenase;
DE   AltName: Full=Nitrogenase component I;
GN   Name=nifD; OrderedLocusNames=MMP0856;
OS   Methanococcus maripaludis (strain S2 / LL).
OC   Archaea; Euryarchaeota; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=267377;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S2 / LL;
RX   PubMed=15466049; DOI=10.1128/JB.186.20.6956-6969.2004;
RA   Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA   Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E.,
RA   Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J.,
RA   Major T.A., Moore B.C., Porat I., Palmeiri A., Rouse G.,
RA   Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B.,
RA   Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A.;
RT   "Complete genome sequence of the genetically tractable
RT   hydrogenotrophic methanogen Methanococcus maripaludis.";
RL   J. Bacteriol. 186:6956-6969(2004).
CC   -!- FUNCTION: This molybdenum-iron protein is part of the nitrogenase
CC       complex that catalyzes the key enzymatic reactions in nitrogen
CC       fixation (By similarity).
CC   -!- CATALYTIC ACTIVITY: 8 reduced ferredoxin + 8 H(+) + N(2) + 16 ATP
CC       + 16 H(2)O = 8 oxidized ferredoxin + H(2) + 2 NH(3) + 16 ADP + 16
CC       phosphate.
CC   -!- COFACTOR: Binds 1 8Fe-7S cluster per heterodimer (By similarity).
CC   -!- COFACTOR: Binds 1 7Fe-Mo-9S-C-homocitryl cluster per subunit (By
CC       similarity).
CC   -!- SUBUNIT: Tetramer of two alpha and two beta chains. Forms complex
CC       with the iron protein (nitrogenase component 2) (By similarity).
CC   -!- SIMILARITY: Belongs to the NifD/NifK/NifE/NifN family.
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DR   EMBL; BX950229; CAF30412.1; -; Genomic_DNA.
DR   RefSeq; NP_987976.1; NC_005791.1.
DR   ProteinModelPortal; P0CW51; -.
DR   EnsemblBacteria; CAF30412; CAF30412; MMP0856.
DR   GeneID; 2761670; -.
DR   KEGG; mmp:MMP0856; -.
DR   HOGENOM; HOG000005528; -.
DR   KO; K02586; -.
DR   OMA; QLKYTYA; -.
DR   BioCyc; MMAR267377:GJ77-886-MONOMER; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0018697; F:carbonyl sulfide nitrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016163; F:nitrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009399; P:nitrogen fixation; IEA:UniProtKB-KW.
DR   InterPro; IPR000510; Nase/OxRdtase_comp1.
DR   InterPro; IPR005974; Nase_asu.
DR   InterPro; IPR010143; Nase_comp1_asu.
DR   InterPro; IPR000318; Nase_comp1_CS.
DR   Pfam; PF00148; Oxidored_nitro; 1.
DR   TIGRFAMs; TIGR01284; alt_nitrog_alph; 1.
DR   TIGRFAMs; TIGR01862; N2-ase-Ialpha; 1.
DR   PROSITE; PS00090; NITROGENASE_1_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Iron; Iron-sulfur; Metal-binding;
KW   Molybdenum; Nitrogen fixation; Nucleotide-binding; Oxidoreductase.
FT   CHAIN         1    477       Nitrogenase molybdenum-iron protein alpha
FT                                chain.
FT                                /FTId=PRO_0000408202.
FT   METAL        49     49       Iron-sulfur (8Fe-7S); shared with beta
FT                                chain (By similarity).
FT   METAL        75     75       Iron-sulfur (8Fe-7S); shared with beta
FT                                chain (By similarity).
FT   METAL       149    149       Iron-sulfur (8Fe-7S); shared with beta
FT                                chain (By similarity).
FT   METAL       267    267       Molybdenum-iron-sulfur-carbon (7Fe-Mo-9S-
FT                                C-homocitryl) (By similarity).
FT   METAL       433    433       Molybdenum-iron-sulfur-carbon (7Fe-Mo-9S-
FT                                C-homocitryl); via pros nitrogen (By
FT                                similarity).
SQ   SEQUENCE   477 AA;  53632 MW;  2773022686D9440C CRC64;
     MPFCLLDVDK DIPEREQHIY IKDSKEPKGH CKQRCNTNTI PGSMTERGCA FAGVKGVITG
     AIKDVLHVVH SPVGCTAYGN GTTKRYPTRP EMPDGSVFPV ENFNLKHIVG TDLTESDVVF
     GGMNKLKKVI REASKEFPFV NAIYVYATCT TGLIGDDLDA VCKEMQAELG KDVVAFNAPG
     FAGPTQSKGH HVGNYTIFEK LVGTKEPPKT TDYDINLIGE YNIDGDYWVL EKYFEDMGIN
     VLSKFTGDAT HGELCWMHKA KLSLVRCQRS ATYVAKLIEE KYGVPYLKVD FFGPEYCAEN
     LRAVGKYFGK EIEAEAVIKK EMEKIQPELD FYKSKLQGKK IWISAGGPKS WHLSKPIEQY
     LGMDVVALSG LFEHEDGYEK MQERAKDGTI IIDDPNTLEM EEVVEKYQPE IVLGGIKEKY
     FFHKLGVPSV MIHSYENGPY IGFEGFVNMA RDIYTAIYNP AWKLMEFEEE EPGDSNE
//
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