GenomeNet

Database: UniProt/SWISS-PROT
Entry: PGRP3_MOUSE
LinkDB: PGRP3_MOUSE
Original site: PGRP3_MOUSE 
ID   PGRP3_MOUSE             Reviewed;         347 AA.
AC   A1A547; E9QMH8; Q6R1Z2;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   19-MAR-2014, entry version 59.
DE   RecName: Full=Peptidoglycan recognition protein 3;
DE   AltName: Full=Peptidoglycan recognition protein I-alpha;
DE            Short=PGLYRPIalpha;
DE            Short=PGRP-I-alpha;
DE   AltName: Full=Peptidoglycan recognition protein intermediate alpha;
DE   Flags: Precursor;
GN   Name=Pglyrp3; Synonyms=Gm420, Pgrpia;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=15177568; DOI=10.1016/j.ygeno.2004.01.003;
RA   Mathur P., Murray B., Crowell T., Gardner H., Allaire N., Hsu Y.-M.,
RA   Thill G., Carulli J.P.;
RT   "Murine peptidoglycan recognition proteins PglyrpIalpha and
RT   PglyrpIbeta are encoded in the epidermal differentiation complex and
RT   are expressed in epidermal and hematopoietic tissues.";
RL   Genomics 83:1151-1163(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Pattern receptor that binds to murein peptidoglycans
CC       (PGN) of Gram-positive bacteria. Has bactericidal activity towards
CC       Gram-positive bacteria. May kill Gram-positive bacteria by
CC       interfering with peptidoglycan biosynthesis. Binds also to Gram-
CC       negative bacteria, and has bacteriostatic activity towards Gram-
CC       negative bacteria. Plays a role in innate immunity (By
CC       similarity).
CC   -!- SUBUNIT: Monomer. Homodimer; disulfide-linked. Heterodimer with
CC       PGLYRP4; disulfide-linked (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC   -!- TISSUE SPECIFICITY: Detected in lung, spleen and stomach, and at
CC       low levels in eye, heart, thymus and testis.
CC   -!- SIMILARITY: Belongs to the N-acetylmuramoyl-L-alanine amidase 2
CC       family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AY518698; AAS49172.1; -; mRNA.
DR   EMBL; AC163215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC128291; AAI28292.1; -; mRNA.
DR   RefSeq; NP_997130.2; NM_207247.4.
DR   RefSeq; XP_006501535.1; XM_006501472.1.
DR   RefSeq; XP_006501536.1; XM_006501473.1.
DR   UniGene; Mm.297406; -.
DR   ProteinModelPortal; A1A547; -.
DR   SMR; A1A547; 28-347.
DR   STRING; 10090.ENSMUSP00000035737; -.
DR   PhosphoSite; A1A547; -.
DR   PRIDE; A1A547; -.
DR   Ensembl; ENSMUST00000047660; ENSMUSP00000035737; ENSMUSG00000042244.
DR   GeneID; 242100; -.
DR   KEGG; mmu:242100; -.
DR   UCSC; uc008qdi.2; mouse.
DR   CTD; 114771; -.
DR   MGI; MGI:2685266; Pglyrp3.
DR   eggNOG; COG5479; -.
DR   GeneTree; ENSGT00390000016833; -.
DR   HOGENOM; HOG000267017; -.
DR   HOVERGEN; HBG053579; -.
DR   InParanoid; A1A547; -.
DR   KO; K01446; -.
DR   OMA; VEKPPNA; -.
DR   OrthoDB; EOG757CZ5; -.
DR   TreeFam; TF323898; -.
DR   NextBio; 385231; -.
DR   PRO; PR:A1A547; -.
DR   Bgee; A1A547; -.
DR   CleanEx; MM_PGLYRP3; -.
DR   Genevestigator; A1A547; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:InterPro.
DR   GO; GO:0042834; F:peptidoglycan binding; ISS:UniProtKB.
DR   GO; GO:0016019; F:peptidoglycan receptor activity; IEA:Ensembl.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR   GO; GO:0016045; P:detection of bacterium; IEA:Ensembl.
DR   GO; GO:0044117; P:growth of symbiont in host; IMP:MGI.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0032689; P:negative regulation of interferon-gamma production; IMP:MGI.
DR   GO; GO:0032827; P:negative regulation of natural killer cell differentiation involved in immune response; IMP:MGI.
DR   GO; GO:0002221; P:pattern recognition receptor signaling pathway; IEA:GOC.
DR   GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR   Gene3D; 3.40.80.10; -; 2.
DR   InterPro; IPR002502; Amidase_domain.
DR   InterPro; IPR015510; PGRP.
DR   InterPro; IPR006619; PGRP_domain_met/bac.
DR   PANTHER; PTHR11022; PTHR11022; 1.
DR   Pfam; PF01510; Amidase_2; 2.
DR   SMART; SM00644; Ami_2; 2.
DR   SMART; SM00701; PGRP; 2.
DR   SUPFAM; SSF55846; SSF55846; 2.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Complete proteome; Disulfide bond;
KW   Glycoprotein; Immunity; Innate immunity; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL        1     26       Potential.
FT   CHAIN        27    347       Peptidoglycan recognition protein 3.
FT                                /FTId=PRO_0000295274.
FT   REGION      270    275       Interaction with murein (By similarity).
FT   BINDING     237    237       Murein (By similarity).
FT   BINDING     248    248       Murein (By similarity).
FT   CARBOHYD    120    120       N-linked (GlcNAc...) (Potential).
FT   DISULFID    184    306       By similarity.
FT   DISULFID    200    244       By similarity.
FT   DISULFID    220    226       By similarity.
FT   CONFLICT    149    149       F -> S (in Ref. 1; AAS49172).
FT   CONFLICT    155    155       Y -> H (in Ref. 1; AAS49172).
FT   CONFLICT    161    161       I -> T (in Ref. 1; AAS49172).
FT   CONFLICT    232    232       D -> G (in Ref. 1; AAS49172 and 3;
FT                                AAI28292).
SQ   SEQUENCE   347 AA;  38503 MW;  1AAEF71374B66F4C CRC64;
     MLVSWDHPKM LPRLLGFLAL SLLACGNPTI VSRKEWGASS LTCRVPLSLP VPYLIIEQVT
     RMQCQDQITC SQVVRVLQSQ YVHNKGWCDI AFNFLVGDDG KVYEGVGWYV QGLHTQGYNN
     VSLGIAFFGS KIGSPSPAAL SATEDLIFFA IQNGYLSPKY IQPFLLKEET CLVPQHSEIP
     KKACPNITPR SAWEARETHC PQMNLPAKFV IIIHTAGKSC NESADCLVRV RDTQSFHIDN
     QDFCDIAYHF LVGQDGEVYE GVGWNIEGSH TYGYNDIALG IAFMGNFVEK PPNEASLKAA
     QSLIQCAVAK GYLTSNYLLM GHSDVSNILS PGQALYNIIK TWPHFKH
//
DBGET integrated database retrieval system