ID PGRP3_MOUSE Reviewed; 347 AA.
AC A1A547; E9QMH8; Q6R1Z2;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 01-MAY-2013, entry version 54.
DE RecName: Full=Peptidoglycan recognition protein 3;
DE AltName: Full=Peptidoglycan recognition protein I-alpha;
DE Short=PGLYRPIalpha;
DE Short=PGRP-I-alpha;
DE AltName: Full=Peptidoglycan recognition protein intermediate alpha;
DE Flags: Precursor;
GN Name=Pglyrp3; Synonyms=Gm420, Pgrpia;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15177568; DOI=10.1016/j.ygeno.2004.01.003;
RA Mathur P., Murray B., Crowell T., Gardner H., Allaire N., Hsu Y.-M.,
RA Thill G., Carulli J.P.;
RT "Murine peptidoglycan recognition proteins PglyrpIalpha and
RT PglyrpIbeta are encoded in the epidermal differentiation complex and
RT are expressed in epidermal and hematopoietic tissues.";
RL Genomics 83:1151-1163(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Pattern receptor that binds to murein peptidoglycans
CC (PGN) of Gram-positive bacteria. Has bactericidal activity towards
CC Gram-positive bacteria. May kill Gram-positive bacteria by
CC interfering with peptidoglycan biosynthesis. Binds also to Gram-
CC negative bacteria, and has bacteriostatic activity towards Gram-
CC negative bacteria. Plays a role in innate immunity (By
CC similarity).
CC -!- SUBUNIT: Monomer. Homodimer; disulfide-linked. Heterodimer with
CC PGLYRP4; disulfide-linked (By similarity).
CC -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC -!- TISSUE SPECIFICITY: Detected in lung, spleen and stomach, and at
CC low levels in eye, heart, thymus and testis.
CC -!- SIMILARITY: Belongs to the N-acetylmuramoyl-L-alanine amidase 2
CC family.
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DR EMBL; AY518698; AAS49172.1; -; mRNA.
DR EMBL; AC163215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC128291; AAI28292.1; -; mRNA.
DR IPI; IPI00411013; -.
DR RefSeq; NP_997130.2; NM_207247.4.
DR UniGene; Mm.297406; -.
DR ProteinModelPortal; A1A547; -.
DR SMR; A1A547; 28-347.
DR STRING; 10090.ENSMUSP00000035737; -.
DR PhosphoSite; A1A547; -.
DR PRIDE; A1A547; -.
DR Ensembl; ENSMUST00000047660; ENSMUSP00000035737; ENSMUSG00000042244.
DR GeneID; 242100; -.
DR KEGG; mmu:242100; -.
DR UCSC; uc008qdi.2; mouse.
DR CTD; 114771; -.
DR MGI; MGI:2685266; Pglyrp3.
DR eggNOG; COG5479; -.
DR GeneTree; ENSGT00390000016833; -.
DR HOGENOM; HOG000267017; -.
DR HOVERGEN; HBG053579; -.
DR InParanoid; A1A547; -.
DR KO; K01446; -.
DR OMA; VEKPPNA; -.
DR OrthoDB; EOG4DFPPK; -.
DR NextBio; 385231; -.
DR Bgee; A1A547; -.
DR CleanEx; MM_PGLYRP3; -.
DR Genevestigator; A1A547; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:InterPro.
DR GO; GO:0042834; F:peptidoglycan binding; ISS:UniProtKB.
DR GO; GO:0016019; F:peptidoglycan receptor activity; IEA:Compara.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Compara.
DR GO; GO:0016045; P:detection of bacterium; IEA:Compara.
DR GO; GO:0044117; P:growth of symbiont in host; IMP:MGI.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IMP:MGI.
DR GO; GO:0032827; P:negative regulation of natural killer cell differentiation involved in immune response; IMP:MGI.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR Gene3D; 3.40.80.10; -; 2.
DR InterPro; IPR002502; Amidase_domain.
DR InterPro; IPR015510; PGRP.
DR InterPro; IPR006619; PGRP_domain_met/bac.
DR PANTHER; PTHR11022; PTHR11022; 1.
DR Pfam; PF01510; Amidase_2; 2.
DR SMART; SM00644; Ami_2; 2.
DR SMART; SM00701; PGRP; 2.
DR SUPFAM; SSF55846; Amidase_2; 2.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Complete proteome; Disulfide bond;
KW Glycoprotein; Immunity; Innate immunity; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1 26 Potential.
FT CHAIN 27 347 Peptidoglycan recognition protein 3.
FT /FTId=PRO_0000295274.
FT REGION 270 275 Interaction with murein (By similarity).
FT BINDING 237 237 Murein (By similarity).
FT BINDING 248 248 Murein (By similarity).
FT CARBOHYD 120 120 N-linked (GlcNAc...) (Potential).
FT DISULFID 184 306 By similarity.
FT DISULFID 200 244 By similarity.
FT DISULFID 220 226 By similarity.
FT CONFLICT 149 149 F -> S (in Ref. 1; AAS49172).
FT CONFLICT 155 155 Y -> H (in Ref. 1; AAS49172).
FT CONFLICT 161 161 I -> T (in Ref. 1; AAS49172).
FT CONFLICT 232 232 D -> G (in Ref. 1; AAS49172 and 3;
FT AAI28292).
SQ SEQUENCE 347 AA; 38503 MW; 1AAEF71374B66F4C CRC64;
MLVSWDHPKM LPRLLGFLAL SLLACGNPTI VSRKEWGASS LTCRVPLSLP VPYLIIEQVT
RMQCQDQITC SQVVRVLQSQ YVHNKGWCDI AFNFLVGDDG KVYEGVGWYV QGLHTQGYNN
VSLGIAFFGS KIGSPSPAAL SATEDLIFFA IQNGYLSPKY IQPFLLKEET CLVPQHSEIP
KKACPNITPR SAWEARETHC PQMNLPAKFV IIIHTAGKSC NESADCLVRV RDTQSFHIDN
QDFCDIAYHF LVGQDGEVYE GVGWNIEGSH TYGYNDIALG IAFMGNFVEK PPNEASLKAA
QSLIQCAVAK GYLTSNYLLM GHSDVSNILS PGQALYNIIK TWPHFKH
//
