ID PP2C3_SCHPO Reviewed; 414 AA.
AC Q09173;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 01-MAY-2013, entry version 103.
DE RecName: Full=Protein phosphatase 2C homolog 3;
DE Short=PP2C-3;
DE EC=3.1.3.16;
GN Name=ptc3; ORFNames=SPAC2G11.07c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales;
OC Schizosaccharomycetaceae; Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=7859738;
RA Shiozaki K., Russell P.;
RT "Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase
RT kinase homolog in the osmoregulation of fission yeast.";
RL EMBO J. 14:492-502(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Has an important role in osmotic stability and cell
CC shape control. It may negatively regulate the osmosensing signal
CC transmitted through wis1 map kinase.
CC -!- CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein +
CC phosphate.
CC -!- COFACTOR: Binds 2 magnesium or manganese ions per subunit (By
CC similarity).
CC -!- SUBUNIT: Monomer.
CC -!- SIMILARITY: Belongs to the PP2C family.
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DR EMBL; L34882; AAA67321.1; -; Genomic_DNA.
DR EMBL; CU329670; CAA91172.1; -; Genomic_DNA.
DR PIR; T38573; S62462.
DR RefSeq; NP_593087.1; NM_001018485.2.
DR ProteinModelPortal; Q09173; -.
DR STRING; 4896.SPAC2G11.07c-1; -.
DR PaxDb; Q09173; -.
DR PRIDE; Q09173; -.
DR EnsemblFungi; SPAC2G11.07c.1; SPAC2G11.07c.1:pep; SPAC2G11.07c.
DR GeneID; 2542008; -.
DR KEGG; spo:SPAC2G11.07c; -.
DR PomBase; SPAC2G11.07c; -.
DR eggNOG; COG0631; -.
DR HOGENOM; HOG000233896; -.
DR KO; K14803; -.
DR OMA; HAGRING; -.
DR OrthoDB; EOG4RFQ28; -.
DR NextBio; 20803088; -.
DR GO; GO:0005829; C:cytosol; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IDA:PomBase.
DR GO; GO:0000173; P:inactivation of MAPK activity involved in osmosensory signaling pathway; IMP:PomBase.
DR GO; GO:0006470; P:protein dephosphorylation; IDA:PomBase.
DR Gene3D; 3.60.40.10; -; 1.
DR InterPro; IPR001932; PP2C-like.
DR InterPro; IPR000222; PP2C_Mn2_Asp60_BS.
DR InterPro; IPR015655; Protein_Pase_2C.
DR PANTHER; PTHR13832; PTHR13832; 1.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00331; PP2C_SIG; 1.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF81606; PP2C-related; 1.
DR PROSITE; PS01032; PP2C; 1.
PE 3: Inferred from homology;
KW Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding;
KW Protein phosphatase; Reference proteome.
FT CHAIN 1 414 Protein phosphatase 2C homolog 3.
FT /FTId=PRO_0000057772.
FT METAL 62 62 Manganese 1 (By similarity).
FT METAL 62 62 Manganese 2 (By similarity).
FT METAL 63 63 Manganese 1; via carbonyl oxygen (By
FT similarity).
FT METAL 230 230 Manganese 2 (By similarity).
FT METAL 279 279 Manganese 2 (By similarity).
FT CONFLICT 196 196 K -> T (in Ref. 1; AAA67321).
SQ SEQUENCE 414 AA; 44857 MW; EFF3A416625A2B11 CRC64;
MGQTLSEPVT EKHSVNGSNE FVLYGLSSMQ GWRISMEDAH SAILSMECSA VKDPVDFFAV
YDGHGGDKVA KWCGSNLPQI LEKNPDFQKG DFVNALKSSF LNADKAILDD DQFHTDPSGC
TATVVLRVGN KLYCANAGDS RTVLGSKGIA KPLSADHKPS NEAEKARICA AGGFVDFGRV
NGNLALSRAI GDFEFKNSNL EPEKQIVTAL PDVVVHEITD DDEFVVLACD GIWDCKTSQQ
VIEFVRRGIV AGTSLEKIAE NLMDNCIASD TETTGLGCDN MTVCIVALLQ ENDKSAWYKK
IADRVAANDG PCAPPEYAEN HGPGWRSGDN NKKVIVPPNF HQVKLNGSDG YDKDANENSK
EDDSTNGSLA AGFRWKEHFF PHKAEEENSS SETDIVNSNK DVADDHKEAV SAAD
//
