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Database: UniProt/SWISS-PROT
Entry: PURL_THET2
LinkDB: PURL_THET2
Original site: PURL_THET2 
ID   PURL_THET2              Reviewed;         725 AA.
AC   Q72IH7;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   14-MAY-2014, entry version 68.
DE   RecName: Full=Phosphoribosylformylglycinamidine synthase 2;
DE            EC=6.3.5.3;
DE   AltName: Full=Phosphoribosylformylglycinamidine synthase II;
DE            Short=FGAM synthase II;
GN   Name=purL; OrderedLocusNames=TT_C1155;
OS   Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae;
OC   Thermus.
OX   NCBI_TaxID=262724;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HB27 / ATCC BAA-163 / DSM 7039;
RX   PubMed=15064768; DOI=10.1038/nbt956;
RA   Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T.,
RA   Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R.,
RA   Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R.,
RA   Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J.;
RT   "The genome sequence of the extreme thermophile Thermus
RT   thermophilus.";
RL   Nat. Biotechnol. 22:547-553(2004).
CC   -!- CATALYTIC ACTIVITY: ATP + N(2)-formyl-N(1)-(5-phospho-D-
CC       ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2-
CC       (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC       phospho-D-ribosyl)glycinamide: step 1/2.
CC   -!- SUBUNIT: Heterodimer of two subunits, PurQ and PurL (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the FGAMS family.
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DR   EMBL; AE017221; AAS81497.1; -; Genomic_DNA.
DR   RefSeq; YP_005124.1; NC_005835.1.
DR   ProteinModelPortal; Q72IH7; -.
DR   STRING; 262724.TTC1155; -.
DR   EnsemblBacteria; AAS81497; AAS81497; TT_C1155.
DR   GeneID; 2774749; -.
DR   KEGG; tth:TTC1155; -.
DR   PATRIC; 23952719; VBITheThe54392_1149.
DR   eggNOG; COG0046; -.
DR   KO; K01952; -.
DR   OMA; MIAVAEC; -.
DR   OrthoDB; EOG6FNHHR; -.
DR   BioCyc; TTHE262724:GCAT-1168-MONOMER; -.
DR   UniPathway; UPA00074; UER00128.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.1330.10; -; 2.
DR   HAMAP; MF_00420; PurL_2; 1.
DR   InterPro; IPR010918; AIR_synth_C_dom.
DR   InterPro; IPR000728; AIR_synth_N_dom.
DR   InterPro; IPR010074; PRibForGlyAmidine_synth_II.
DR   InterPro; IPR016188; PurM_N-like.
DR   Pfam; PF00586; AIRS; 2.
DR   Pfam; PF02769; AIRS_C; 2.
DR   SUPFAM; SSF55326; SSF55326; 2.
DR   SUPFAM; SSF56042; SSF56042; 2.
DR   TIGRFAMs; TIGR01736; FGAM_synth_II; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding;
KW   Purine biosynthesis.
FT   CHAIN         1    725       Phosphoribosylformylglycinamidine
FT                                synthase 2.
FT                                /FTId=PRO_0000100502.
FT   NP_BIND      98    109       ATP (Potential).
SQ   SEQUENCE   725 AA;  78643 MW;  C5CC5FAE833F0199 CRC64;
     MEALAKEIGI PEGEYREIVQ RLGREPNRVE LLLFKVMWSE HCAYKNSRPL LKALPKEGEA
     VLQGPGENAG VVRVGEGWAV AFKIESHNHP SAVEPFQGAA TGVGGILRDI MSMGARPIAL
     LDSLRFGPPE EARSRYLLKG VVSGIAFYGN AIGVPTVGGD LYFHEGYREN PLVNAMCLGL
     LREEHLKRSR ASLGRPIYYA GAKTGRDGIG GAAFASRELK EEKAEDRPAV QVGDPFLGKL
     LMEATLEAIE LDLVEGVQDM GAAGLTSSLS ELAHKSGLGV ELHLDLVPTR EEGMTPEELL
     LSESQERMVL VPKEGKEKAL EEVFGRWGLD CVPVARTIPE RVFRVLFRGE VVAEVPTEAL
     AEAPTYVRVG REDPEVRRLR ETPIPPLEAD PQEVLRRLLA SPNLASREAV YERYDHQVGT
     RTALLPGKGD AAVLWIKGTR LGVAAKVDQN PRYSRLHPRL GAMHALAEAC RNVSVVGAKP
     LAYTDGLNLG SPETPEGYHE LAETIAGLKE ASEALGVPVV SGNVSLYNES GGKRIPPTAM
     VGVVGVLEVD KRAEMGFRRP GEVLLLIGEE RGELGASEVL YLLTGKEFGH PPRLDLGREK
     AVQEAIRDLI QRGLTRTAHD VAEGGLLLAL AEMTFPYGVG ATVEVREEGL EALFGEAPSR
     VLFTVEKTRL QEATLLLEER GLPYRVLGET GGKSLTVLTP GGVLEWSLEE LLSAWKAPLR
     EVLDG
//
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