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Database: UniProt/SWISS-PROT
Entry: RPOC_MYCS2
LinkDB: RPOC_MYCS2
Original site: RPOC_MYCS2 
ID   RPOC_MYCS2              Reviewed;        1317 AA.
AC   A0QS66; I7FY06;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   26-NOV-2014, entry version 57.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta' {ECO:0000255|HAMAP-Rule:MF_01322};
DE            Short=RNAP subunit beta' {ECO:0000255|HAMAP-Rule:MF_01322};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01322};
DE   AltName: Full=RNA polymerase subunit beta' {ECO:0000255|HAMAP-Rule:MF_01322};
DE   AltName: Full=Transcriptase subunit beta' {ECO:0000255|HAMAP-Rule:MF_01322};
GN   Name=rpoC {ECO:0000255|HAMAP-Rule:MF_01322};
GN   OrderedLocusNames=MSMEG_1368, MSMEI_1329;
OS   Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS], AND IDENTIFICATION OF N-TERMINUS.
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through
RT   orthology and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
RN   [4]
RP   FUNCTION, AND SUBUNIT.
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=19926651; DOI=10.1099/mic.0.033670-0;
RA   Dey A., Verma A.K., Chatterji D.;
RT   "Role of an RNA polymerase interacting protein, MsRbpA, from
RT   Mycobacterium smegmatis in phenotypic tolerance to rifampicin.";
RL   Microbiology 156:873-883(2010).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription
CC       of DNA into RNA using the four ribonucleoside triphosphates as
CC       substrates. {ECO:0000255|HAMAP-Rule:MF_01322,
CC       ECO:0000269|PubMed:19926651}.
CC   -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
CC       + RNA(n+1). {ECO:0000255|HAMAP-Rule:MF_01322}.
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1
CC       beta' and 1 omega subunit. When a sigma factor is associated with
CC       the core the holoenzyme is formed, which can initiate
CC       transcription. {ECO:0000255|HAMAP-Rule:MF_01322,
CC       ECO:0000269|PubMed:19926651}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01322}.
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DR   EMBL; CP000480; ABK71951.1; -; Genomic_DNA.
DR   EMBL; CP001663; AFP37802.1; -; Genomic_DNA.
DR   RefSeq; YP_006566097.1; NC_018289.1.
DR   RefSeq; YP_885754.1; NC_008596.1.
DR   ProteinModelPortal; A0QS66; -.
DR   SMR; A0QS66; 9-136.
DR   IntAct; A0QS66; 2.
DR   STRING; 246196.MSMEG_1368; -.
DR   PRIDE; A0QS66; -.
DR   EnsemblBacteria; ABK71951; ABK71951; MSMEG_1368.
DR   EnsemblBacteria; AFP37802; AFP37802; MSMEI_1329.
DR   GeneID; 4532832; -.
DR   KEGG; msm:MSMEG_1368; -.
DR   PATRIC; 18075191; VBIMycSme59918_1352.
DR   eggNOG; COG0086; -.
DR   HOGENOM; HOG000218386; -.
DR   KO; K03046; -.
DR   OMA; IWNTFTK; -.
DR   OrthoDB; EOG6M9DS6; -.
DR   BioCyc; MSME246196:GJ4Y-1368-MONOMER; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_01322; RNApol_bact_RpoC; 1.
DR   InterPro; IPR012754; DNA-dir_RpoC_beta_prime.
DR   InterPro; IPR000722; RNA_pol_asu.
DR   InterPro; IPR006592; RNA_pol_N.
DR   InterPro; IPR007080; RNA_pol_Rpb1_1.
DR   InterPro; IPR007066; RNA_pol_Rpb1_3.
DR   InterPro; IPR007083; RNA_pol_Rpb1_4.
DR   InterPro; IPR007081; RNA_pol_Rpb1_5.
DR   Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR   Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR   Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR   Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR   Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR   SMART; SM00663; RPOLA_N; 1.
DR   TIGRFAMs; TIGR02386; rpoC_TIGR; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; DNA-directed RNA polymerase;
KW   Nucleotidyltransferase; Reference proteome; Transcription;
KW   Transferase.
FT   CHAIN         1   1317       DNA-directed RNA polymerase subunit
FT                                beta'.
FT                                /FTId=PRO_0000308855.
SQ   SEQUENCE   1317 AA;  146513 MW;  2C9C7E156E76FBEA CRC64;
     MLDVNFFDEL RIGLATADDI RNWSYGEVKK PETINYRTLK PEKDGLFCEK IFGPTRDWEC
     YCGKYKRVRF KGIICERCGV EVTRAKVRRE RMGHIELAAP VTHIWYFKGV PSRLGYLLDL
     APKDLEKIIY FAAYVITSVD DEMRHNELST LEAEMAVEKK AVEDQRDADL EARAQKLEAD
     LAELEAEGAK SDVRRKVRDS GEREMRQLRD RAQRELDRLD EIWNTFTKLA PKQLIVDEVL
     YRELQDRYGE YFTGAMGAES IKKLIENFDI DAEAESLREV IRSGKGQKKL RALKRLKVVA
     AFQQSGNSPM GMVLDAVPVI PPELRPMVQL DGGRFATSDL NDLYRRVINR NNRLKRLIDL
     GAPEIIVNNE KRMLQESVDA LFDNGRRGRP VTGPGNRPLK SLSDLLKGKQ GRFRQNLLGK
     RVDYSGRSVI VVGPQLKLHQ CGLPKLMALE LFKPFVMKRL VDLNHAQNIK SAKRMVERQR
     PQVWDVLEEV IAEHPVLLNR APTLHRLGIQ AFEPQLVEGK AIQLHPLVCE AFNADFDGDQ
     MAVHLPLSAE AQAEARILML SSNNILSPAS GKPLAMPRLD MVTGLYYLTT LVEGATGEYQ
     AATKDAPEQG VYSSPAEAIM AMDRGALSVR AKIKVRLTEL RPPTDLEAQL FENGWKPGDA
     WTAETTLGRV MFNELLPKSY PFVNEQMHKK VQARIINDLA ERFPMIVVAQ TVDKLKDAGF
     YWATRSGVTV SMADVLVPPQ KQEILERHEA EADAIERKYQ RGALNHTERN ESLVKIWQDA
     TEEVGKALEE FYPADNPIIT IVKSGATGNL TQTRTLAGMK GLVTNPKGEF IPRPIKSSFR
     EGLTVLEYFI NTHGARKGLA DTALRTADSG YLTRRLVDVS QDVIVREHDC ETERGINVTL
     AERGPDGTLI RDAHVETSAF ARTLATDAVD ANGNVIIERG HDLGDPAIDA LLAAGITTVK
     VRSVLTCTSA TGVCAMCYGR SMATGKLVDI GEAVGIVAAQ SIGEPGTQLT MRTFHQGGVT
     GGADIVGGLP RVQELFEARV PRNKAPIADV AGRVRLEESD KFFKITIVPD DGGEEVVYDK
     LSKRQRLRVI THEDGTEGVL SDGDHVEVGD QLMEGAADPH EVLRVQGPRE VQIHLVKEVQ
     EVYRAQGVSI HDKHIEVIVR QMLRRVTIID SGSTEFLPGS LTERAEFEAE NRRVVAEGGE
     PAAGRPVLMG ITKASLATDS WLSAASFQET TRVLTDAAIN CRSDKLNGLK ENVIIGKLIP
     AGTGISRYRN IQVQPTEEAR AAAYTIPSYE DQYYSPDFGQ ATGAAVPLDD YGYSDYR
//
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