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Database: UniProt/SWISS-PROT
Entry: SET1B_CHICK
LinkDB: SET1B_CHICK
Original site: SET1B_CHICK 
ID   SET1B_CHICK             Reviewed;        2008 AA.
AC   Q5F3P8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   28-MAR-2018, entry version 90.
DE   RecName: Full=Histone-lysine N-methyltransferase SETD1B;
DE            EC=2.1.1.43;
DE   AltName: Full=SET domain-containing protein 1B;
GN   Name=SETD1B; ORFNames=RCJMB04_10j6;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J.,
RA   Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M.,
RA   Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Histone methyltransferase that specifically methylates
CC       'Lys-4' of histone H3, when part of the SET1 histone
CC       methyltransferase (HMT) complex, but not if the neighboring 'Lys-
CC       9' residue is already methylated. H3 'Lys-4' methylation
CC       represents a specific tag for epigenetic transcriptional
CC       activation (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}. Chromosome
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190}.
DR   EMBL; AJ851602; CAH65236.1; -; mRNA.
DR   RefSeq; NP_001025832.1; NM_001030661.1.
DR   UniGene; Gga.48952; -.
DR   ProteinModelPortal; Q5F3P8; -.
DR   SMR; Q5F3P8; -.
DR   STRING; 9031.ENSGALP00000038427; -.
DR   PaxDb; Q5F3P8; -.
DR   GeneID; 416851; -.
DR   KEGG; gga:416851; -.
DR   CTD; 23067; -.
DR   eggNOG; KOG1080; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   HOGENOM; HOG000168216; -.
DR   HOVERGEN; HBG055596; -.
DR   InParanoid; Q5F3P8; -.
DR   KO; K11422; -.
DR   PhylomeDB; Q5F3P8; -.
DR   PRO; PR:Q5F3P8; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; IEA:InterPro.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051568; P:histone H3-K4 methylation; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   CDD; cd12549; RRM_Set1B; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR024657; COMPASS_Set1_N-SET.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR034468; Set1B_RRM.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR037842; SETD1B.
DR   PANTHER; PTHR22884:SF475; PTHR22884:SF475; 1.
DR   Pfam; PF11764; N-SET; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM01291; N-SET; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00360; RRM; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50102; RRM; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Activator; Chromatin regulator; Chromosome; Complete proteome;
KW   Methyltransferase; Nucleus; Reference proteome; RNA-binding;
KW   S-adenosyl-L-methionine; Transcription; Transcription regulation;
KW   Transferase.
FT   CHAIN         1   2008       Histone-lysine N-methyltransferase
FT                                SETD1B.
FT                                /FTId=PRO_0000316995.
FT   DOMAIN      111    199       RRM. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00176}.
FT   DOMAIN     1869   1986       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   DOMAIN     1992   2008       Post-SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00155}.
FT   COMPBIAS    674    748       Pro-rich.
FT   COMPBIAS   1010   1271       Glu-rich.
FT   COMPBIAS   1504   1609       Pro-rich.
SQ   SEQUENCE   2008 AA;  223085 MW;  3A1CD3C9279D614C CRC64;
     MSFREIKAGE KAKHPEDHGK KQSSSWINGM ENSTQASTSV EKRNHHWRSY KLIIDPALKK
     GQHKLYRYDG QHFSMPNSGI APVDCVRDPR IGRIWTKTKE LELSVPKFKI DEFYVGPVPP
     KQVTFAKLND NIRENFLTDM CKKYGEVEEV EILYNPKNKK HLGIAKVIFA TVKGAREAVQ
     HLHNTSVMGN IIHVELDTKG ETRMRFYELL VNGLYTPQTL PVGTEQDASP TVNETLQLTD
     SLKRLKDSNL SSVGSSVTPN SSTPFSHDTA YSSCRQDTPN SFSQFTPQSQ GTPHTPRLGT
     PFSQDSTYSS RQTTPVYHFG QDSGYKHRRH ETKFTDAYNR RPGGHHYVHN SPGVFRGTEH
     QFSTFKSHQQ EPVQFSHTPP LSHSSSSSYK SAFSPYQAPA VFPQSEEQPF AQTSREAEYR
     RPAPPPAEMV VESSAATSAD FAPVKEKPEE PPPLPDSNSA PEPSAPSFSQ TPERSETPGT
     PTMESEMQHN SLDSRIEMLL KEQRTKLPFL NEHDSDNEVR MEGSPISSSS SQLSPIPMYG
     SNSQPGYRAQ TPSSRPSSTG LEDISPTPLP DSDDDEPIPG TASLNQNSRG TSEASMTPID
     QLNRASKVET LEVKEMVPGD QTPTSEKMDE SQHSSGEDME ISDDEMNSAP ITSAECAKTI
     VVNSSVSNAA VMAPSIPPLP PPPGFPPLPP PPPPPPQPAF PMPPPLPPPP PPTHPAVTVP
     PPPLPAPPGV PPPHILPPLP PFHPGMFPVM QVDMISVLGN HWGGMPMSFQ MQTQMLSRMM
     QAQNTYQYPP FMGGRMQFVN LPPYRPFSMG AARGRGQQWP PLPKFDPSVP PPGYEPKKED
     PHKATVDGVL LVIVKELKAI MKRDLNRKMV EVVAFRAFDD WWDKKERLAK ASLTPVKSGG
     ELEEKPKPKD RITSCLLENW NKGEGLGYEG IGLGIGLRGA IRLPSFKVKR KEPPEAASAG
     DQKRIRPSTS VDDEDEESER DRDASDTTSD LSKKDAEAVG LRRRPARPLE LDSEGEEGDE
     TSGKEEESSS EKEEEQEEEG GLVKAAPGKE EEEDEDDEED EDDDEDEEDE EDYEETGVET
     SDKEEEQDSE EEDAASPSSS KAEVESSDES EDSSEFESSS DSDEDDDEEE EEEEDEEEEE
     EEEVAEDQDR EAMVAETEHE PASHELPDDK RETILELYPV DYMDATGLGL SEPALVEKDE
     GMEEVKAEES ECDQVPEESI AAETLKQLVM ERDQETKLAL SPICRPVEEP EPIVMLEPEV
     QECPKPESQD EAGTVCLSTP VAVFGEARPS KSSFFSKSDD SCLETHVKTK LPSAVEEEDR
     LPRTPGREVV VHSETDILLL PAHKVPSSTV PLPSTPGKEE SVVPPEKFPE QLMVTKTSIE
     EEIPRTPGRD ILAKSSHPLG KSQSTDTVPA TPGSDAPLTG SSLTLSSPQV PGSPFSYPSQ
     SPGINSGIPR TPGRDFNFTP TFPEAGATIP CLLSGKKQSE DDLDEKPFKE PLGASLTISM
     NSVPSPIPFA SPTQADFRTD MGLPPNEPIP IAALPCIPGD GRMPIEECKA EVKSVLLSPE
     APVGASILPP PPPHSVLPKR RPGRPRRSPP SVLSLDMYSG KTIEPPPVPV ALVESAMSKE
     LLSAHPDAFY GLKDPEAVTL DFRNDSFHEK IAAETVAEKL PFKELENQWN EDFKEEEAHA
     KPKRQWRRQK KSPEHLPVIP SPEYSPPQPQ FRPRSEFEEM TILYDIWNGG IDEEDIKFMC
     ITYDRLLQQD NGMDWLNDTL WVFHPSTSFS TPKKKKRDDG MREHVTGCAR SEGYYKIDKK
     DKLKYLNNSR AFAEEPPADT QGMSIPAQPH ASTRAGSERR SEQRRLLSSF TGSCDSDLLK
     FNQLKFRKKK LKFCKSHIHD WGLFAMEPIA ADEMVIEYVG QNIRQVIADM REKRYEDEGI
     GSSYMFRVDH DTIIDATKCG NFARFINHSC NPNCYAKVIT VESQKKIVIY SKQHINVNEE
     ITYDYKFPIE DVKIPCLCGS ENCRGTLN
//
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