GenomeNet

Database: UniProt/SWISS-PROT
Entry: SODC_DROVI
LinkDB: SODC_DROVI
Original site: SODC_DROVI 
ID   SODC_DROVI              Reviewed;         153 AA.
AC   P10791; B4LC46;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-OCT-2017, entry version 126.
DE   RecName: Full=Superoxide dismutase [Cu-Zn];
DE            EC=1.15.1.1;
GN   Name=Sod; ORFNames=GJ11304;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2928122; DOI=10.1093/nar/17.5.2133;
RA   Kwiatowski J., Ayala F.J.;
RT   "Drosophila virilis Cu-Zn superoxide dismutase gene sequence.";
RL   Nucleic Acids Res. 17:2133-2133(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Destroys radicals which are normally produced within the
CC       cells and which are toxic to biological systems.
CC   -!- CATALYTIC ACTIVITY: 2 superoxide + 2 H(+) = O(2) + H(2)O(2).
CC   -!- COFACTOR:
CC       Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC       Note=Binds 1 copper ion per subunit.;
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the Cu-Zn superoxide dismutase family.
CC       {ECO:0000305}.
DR   EMBL; X13831; CAA32060.1; -; Genomic_DNA.
DR   EMBL; CH940647; EDW70874.1; -; Genomic_DNA.
DR   PIR; S03606; S03606.
DR   RefSeq; XP_002048532.1; XM_002048496.2.
DR   ProteinModelPortal; P10791; -.
DR   SMR; P10791; -.
DR   STRING; 7244.FBpp0225721; -.
DR   EnsemblMetazoa; FBtr0227229; FBpp0225721; FBgn0013096.
DR   GeneID; 6624514; -.
DR   KEGG; dvi:Dvir_GJ11304; -.
DR   FlyBase; FBgn0013096; Dvir\Sod.
DR   eggNOG; KOG0441; Eukaryota.
DR   eggNOG; COG2032; LUCA.
DR   InParanoid; P10791; -.
DR   KO; K04565; -.
DR   OMA; IHTFGDN; -.
DR   OrthoDB; EOG091G0OG2; -.
DR   PhylomeDB; P10791; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   Bgee; FBgn0013096; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   CDD; cd00305; Cu-Zn_Superoxide_Dismutase; 1.
DR   Gene3D; 2.60.40.200; -; 1.
DR   InterPro; IPR036423; SOD-like_Cu/Zn_dom_sf.
DR   InterPro; IPR024134; SOD_Cu/Zn_/chaperone.
DR   InterPro; IPR018152; SOD_Cu/Zn_BS.
DR   InterPro; IPR001424; SOD_Cu_Zn_dom.
DR   PANTHER; PTHR10003; PTHR10003; 1.
DR   Pfam; PF00080; Sod_Cu; 1.
DR   PRINTS; PR00068; CUZNDISMTASE.
DR   SUPFAM; SSF49329; SSF49329; 1.
DR   PROSITE; PS00087; SOD_CU_ZN_1; 1.
DR   PROSITE; PS00332; SOD_CU_ZN_2; 1.
PE   3: Inferred from homology;
KW   Antioxidant; Complete proteome; Copper; Cytoplasm; Disulfide bond;
KW   Metal-binding; Oxidoreductase; Reference proteome; Zinc.
FT   INIT_MET      1      1       Removed. {ECO:0000250}.
FT   CHAIN         2    153       Superoxide dismutase [Cu-Zn].
FT                                /FTId=PRO_0000164098.
FT   METAL        45     45       Copper; catalytic.
FT   METAL        47     47       Copper; catalytic.
FT   METAL        62     62       Copper; catalytic.
FT   METAL        62     62       Zinc; structural.
FT   METAL        70     70       Zinc; structural.
FT   METAL        79     79       Zinc; structural.
FT   METAL        82     82       Zinc; structural.
FT   METAL       119    119       Copper; catalytic.
FT   DISULFID     56    145       {ECO:0000250}.
SQ   SEQUENCE   153 AA;  15770 MW;  26E121BBF6B7A25C CRC64;
     MVVKAVCVIN GDAKGTVFFE QEGEGCPVKV TGEVTGLAKG QHGFHVHEFG DNTNGCMSSG
     PHFNPYQKEH GAPTDENRHL GDLGNIIANG DGPTPVNICD CKITLLGANS IIGRTVVVHA
     DPDDLGKGGH ELSKTTGNAG ARIGCGVIGI AKI
//
DBGET integrated database retrieval system