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Database: UniProt/SWISS-PROT
Entry: SODF_AERPE
LinkDB: SODF_AERPE
Original site: SODF_AERPE 
ID   SODF_AERPE              Reviewed;         214 AA.
AC   Q9Y8H8;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-OCT-2017, entry version 105.
DE   RecName: Full=Superoxide dismutase [Mn/Fe];
DE            EC=1.15.1.1;
GN   Name=sod; OrderedLocusNames=APE_0741;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC
OS   100138 / K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10393342; DOI=10.1093/oxfordjournals.jbchem.a022426;
RA   Yamano S., Sako Y., Nomura N., Maruyama T.;
RT   "A cambialistic SOD in a strictly aerobic hyperthermophilic archaeon,
RT   Aeropyrum pernix.";
RL   J. Biochem. 126:218-225(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y.,
RA   Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H.,
RA   Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H.,
RA   Takamiya M., Masuda S., Funahashi T., Tanaka T., Kudoh Y.,
RA   Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y.,
RA   Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic
RT   crenarchaeon, Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC       produced within the cells and which are toxic to biological
CC       systems.
CC   -!- CATALYTIC ACTIVITY: 2 superoxide + 2 H(+) = O(2) + H(2)O(2).
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000250};
CC       Note=Binds 1 Mn(2+) or Fe(2+) ion per subunit. {ECO:0000250};
CC   -!- INTERACTION:
CC       Self; NbExp=3; IntAct=EBI-8549588, EBI-8549588;
CC   -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase
CC       family. {ECO:0000305}.
DR   EMBL; AB012621; BAA76442.1; -; Genomic_DNA.
DR   EMBL; BA000002; BAA79718.1; -; Genomic_DNA.
DR   PIR; F72664; F72664.
DR   PDB; 3AK1; X-ray; 1.57 A; A/B/C/D=1-214.
DR   PDB; 3AK2; X-ray; 1.35 A; A/B/C/D=1-214.
DR   PDB; 3AK3; X-ray; 1.48 A; A/B/C/D=1-214.
DR   PDBsum; 3AK1; -.
DR   PDBsum; 3AK2; -.
DR   PDBsum; 3AK3; -.
DR   ProteinModelPortal; Q9Y8H8; -.
DR   SMR; Q9Y8H8; -.
DR   MINT; MINT-8075653; -.
DR   STRING; 272557.APE_0741; -.
DR   EnsemblBacteria; BAA79718; BAA79718; APE_0741.
DR   KEGG; ape:APE_0741; -.
DR   PATRIC; fig|272557.25.peg.534; -.
DR   eggNOG; arCOG04147; Archaea.
DR   eggNOG; COG0605; LUCA.
DR   HOGENOM; HOG000013583; -.
DR   KO; K04564; -.
DR   OMA; KWGSFDK; -.
DR   OrthoDB; POG093Z0AKF; -.
DR   BRENDA; 1.15.1.1; 171.
DR   EvolutionaryTrace; Q9Y8H8; -.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001189; Mn/Fe_SOD.
DR   InterPro; IPR019833; Mn/Fe_SOD_BS.
DR   InterPro; IPR019832; Mn/Fe_SOD_C.
DR   InterPro; IPR019831; Mn/Fe_SOD_N.
DR   InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR   InterPro; IPR036314; SOD_C_sf.
DR   Pfam; PF02777; Sod_Fe_C; 1.
DR   Pfam; PF00081; Sod_Fe_N; 1.
DR   PIRSF; PIRSF000349; SODismutase; 1.
DR   PRINTS; PR01703; MNSODISMTASE.
DR   SUPFAM; SSF46609; SSF46609; 1.
DR   SUPFAM; SSF54719; SSF54719; 1.
DR   PROSITE; PS00088; SOD_MN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Iron; Manganese; Metal-binding;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN         1    214       Superoxide dismutase [Mn/Fe].
FT                                /FTId=PRO_0000160005.
FT   METAL        31     31       Manganese or iron. {ECO:0000250}.
FT   METAL        79     79       Manganese or iron. {ECO:0000250}.
FT   METAL       165    165       Manganese or iron. {ECO:0000250}.
FT   METAL       169    169       Manganese or iron. {ECO:0000250}.
FT   TURN         16     22       {ECO:0000244|PDB:3AK2}.
FT   HELIX        25     33       {ECO:0000244|PDB:3AK2}.
FT   HELIX        35     54       {ECO:0000244|PDB:3AK2}.
FT   HELIX        62     82       {ECO:0000244|PDB:3AK2}.
FT   TURN         83     85       {ECO:0000244|PDB:3AK2}.
FT   STRAND       92     94       {ECO:0000244|PDB:3AK2}.
FT   HELIX        98    108       {ECO:0000244|PDB:3AK2}.
FT   HELIX       111    123       {ECO:0000244|PDB:3AK2}.
FT   STRAND      126    136       {ECO:0000244|PDB:3AK2}.
FT   TURN        137    140       {ECO:0000244|PDB:3AK2}.
FT   STRAND      141    148       {ECO:0000244|PDB:3AK2}.
FT   TURN        149    151       {ECO:0000244|PDB:3AK2}.
FT   STRAND      159    165       {ECO:0000244|PDB:3AK2}.
FT   HELIX       168    170       {ECO:0000244|PDB:3AK2}.
FT   HELIX       172    175       {ECO:0000244|PDB:3AK2}.
FT   HELIX       179    186       {ECO:0000244|PDB:3AK2}.
FT   HELIX       187    189       {ECO:0000244|PDB:3AK2}.
FT   HELIX       192    205       {ECO:0000244|PDB:3AK2}.
FT   HELIX       207    209       {ECO:0000244|PDB:3AK2}.
SQ   SEQUENCE   214 AA;  24577 MW;  641122779485DF0A CRC64;
     MVSFKRYELP PLPYNYNALE PYIIEEIMKL HHQKHHNTYV KGANAALEKI EKHLKGEIQI
     DVRAVMRDFS FNYAGHIMHT IFWPNMAPPG KGGGTPGGRV ADLIEKQFGG FEKFKALFSA
     AAKTVEGVGW GVLAFDPLTE ELRILQVEKH NVLMTAGLVP ILVIDVWEHA YYLQYKNDRG
     SYVENWWNVV NWDDVEKRLE QALNNAKPLY LLPQ
//
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