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Database: UniProt/SWISS-PROT
Entry: SYFA_LACDA
LinkDB: SYFA_LACDA
Original site: SYFA_LACDA 
ID   SYFA_LACDA              Reviewed;         349 AA.
AC   Q1G9C7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 1.
DT   19-FEB-2014, entry version 58.
DE   RecName: Full=Phenylalanine--tRNA ligase alpha subunit;
DE            EC=6.1.1.20;
DE   AltName: Full=Phenylalanyl-tRNA synthetase alpha subunit;
DE            Short=PheRS;
GN   Name=pheS; OrderedLocusNames=Ldb1487;
OS   Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM
OS   20081).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=390333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11842 / DSM 20081;
RX   PubMed=16754859; DOI=10.1073/pnas.0603024103;
RA   van de Guchte M., Penaud S., Grimaldi C., Barbe V., Bryson K.,
RA   Nicolas P., Robert C., Oztas S., Mangenot S., Couloux A., Loux V.,
RA   Dervyn R., Bossy R., Bolotin A., Batto J.-M., Walunas T.,
RA   Gibrat J.-F., Bessieres P., Weissenbach J., Ehrlich S.D., Maguin E.;
RT   "The complete genome sequence of Lactobacillus bulgaricus reveals
RT   extensive and ongoing reductive evolution.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:9274-9279(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + L-phenylalanine + tRNA(Phe) = AMP +
CC       diphosphate + L-phenylalanyl-tRNA(Phe).
CC   -!- COFACTOR: Binds 2 magnesium ions per tetramer (By similarity).
CC   -!- SUBUNIT: Tetramer of two alpha and two beta subunits (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase
CC       family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
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DR   EMBL; CR954253; CAI98287.1; -; Genomic_DNA.
DR   RefSeq; YP_619313.1; NC_008054.1.
DR   ProteinModelPortal; Q1G9C7; -.
DR   SMR; Q1G9C7; 81-349.
DR   STRING; 390333.Ldb1487; -.
DR   EnsemblBacteria; CAI98287; CAI98287; Ldb1487.
DR   GeneID; 4085057; -.
DR   KEGG; ldb:Ldb1487; -.
DR   PATRIC; 22218442; VBILacDel123523_1338.
DR   eggNOG; COG0016; -.
DR   HOGENOM; HOG000242675; -.
DR   KO; K01889; -.
DR   OMA; FEALNTP; -.
DR   OrthoDB; EOG6WX4QN; -.
DR   ProtClustDB; PRK00488; -.
DR   BioCyc; LDEL390333:GIXG-1467-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR   GO; GO:0006432; P:phenylalanyl-tRNA aminoacylation; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00281; Phe_tRNA_synth_alpha1; 1.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR004529; Phe-tRNA-synth_IIc_asu.
DR   InterPro; IPR004188; Phe-tRNA_ligase_II_N.
DR   InterPro; IPR022911; Phe_tRNA_ligase_alpha1_bac.
DR   InterPro; IPR002319; Phenylalanyl-tRNA_Synthase.
DR   InterPro; IPR010978; tRNA-bd_arm.
DR   Pfam; PF02912; Phe_tRNA-synt_N; 1.
DR   Pfam; PF01409; tRNA-synt_2d; 1.
DR   SUPFAM; SSF46589; SSF46589; 1.
DR   TIGRFAMs; TIGR00468; pheS; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm;
KW   Ligase; Magnesium; Metal-binding; Nucleotide-binding;
KW   Protein biosynthesis.
FT   CHAIN         1    349       Phenylalanine--tRNA ligase alpha subunit.
FT                                /FTId=PRO_1000006848.
FT   METAL       259    259       Magnesium (By similarity).
SQ   SEQUENCE   349 AA;  39747 MW;  947B935DD993F30B CRC64;
     MDLFDRLKEL REQGLAEIKE AESEKSLNDV RVKLVGKKGE LTQILHQMKD VAPEKRREVG
     QKVNELRDLF NENLASAKDN LIEKAIEARL EAEKIDVTLP GRRKHVGSKH PIRIIQDDLE
     RFFIGMGYQV VQGPEIESEH YNFEMLNLPK DHPARDMQAT FYVDADHLLR SQTSPVQART
     MEKHDFDKGD LKMISPGKVY RRDDDDATHS HQFMQMEGLV VGKNISLSDL KGTLELVAKH
     EFGQDRETRL RPSYFPFTEP SVEMDVSCFE CGGKGCAICK NTGWIEVLGA GIVHPNVLSA
     AGIDPSVYSG FAFGLGLDRF AILKYGIDDI RDFYSDDVRF LQQFRQEED
//
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